Preparation, characterization and in vitro drug release of poly-∈-caprolactone and hydroxypropyl methylcellulose phthalate ketoprofen loaded microspheres (original) (raw)
Related papers
A Study On Release Rate From Tramadol HCl Loaded Microspheres Prepared By Using Different Polymers
2021
Tramadol which is an opioid analgesic used to treat moderate to moderately severe pain act primarily by binding to the μ-opioid receptor and secondly by inhibiting the reactivity of norepinephrine and serotonin. The emulsion solvent evaporation method was used to encapsulate the polymers EC, HPMC K4M, and CAP, and characterization of formulations was performed. The microspheres obtained were white and spherical. The in vitro studies of the microspheres was performed using phosphate buffer of pH 6.8 at a temperature of 37 degrees Celsius and 100 rpm in 900ml USP basket type dissolution rate test apparatus for 8 hours and various parameters of the formulation were evaluated. Formulation F6 exhibited a higher yield and formulation of F3 entrapped maximum drug. The effect of the nature of polymer and polymer content was clearly visible on the drug release. The controlled release of the drug from the tramadol hydrochloride microsphere provides enhanced plasma drug content and higher bioa...
Preparation, characterization, and in vitro release of ketoprofen loaded polymeric microspheres
2016
The purpose of this study was to prepare and to evaluate ketoprofen microspheres fabricated from biodegradable polymers (polylactic acid and polylactic-coglycolic acid) by oil in water solvent evaporation method in different ratios of drug to polymer. The prepared microspheres were evaluated for percentage yield, entrapment efficiency, drug loading, drug polymer compatibility and in-vitro release of the drug. The percentage yields of different formulations were in the range of 81.61% 96.18% while percentage of drug entrapment efficiency was in the range of 71.62%86.40% and found to be higher in case of PLGA based microspheres as compared with PLA based microspheres. FT-IR spectra of the microspheres showed no interaction between the drug and the polymers. The release profile of ketoprofen from the different formulations was pH dependent. Lower release was observed in acidic medium while in phosphate buffer, sustained drug release was observed over 24 hours. As the drug to polymer ra...
Materials Science and Engineering: C, 2009
Poly-(3-hydroxybutyrate) (P(3HB)) is a biodegradable and biocompatible polymer that has been used to obtain polymer-based drug carriers. However, due to the high crystallinity degree of this polymer, drug release from P(3HB) microspheres frequently occurs at excessive rates. In this study, two strategies for prolonging ibuprofen release from P(3HB)-based microspheres were tested: blending with poly(D,L-lactide)-b-polyethylene glycol (mPEG-PLA); and obtaining composite particles with gelatin (GEL). SEM micrographs showed particles that were spherical and had a rough surface. A slight decrease of the crystallinity degree of P(3HB) was observed only in the DSC thermogram obtained from unloaded-microspheres prepared from 1:1 P(3HB):mPEG-PLA blend. For IBF-loaded microspheres, a reduction of around 10 °C in the melting temperature of P(3HB) was observed, indicating that the crystalline structure of the polymer was affected in the presence of the drug. DSC studies also yielded evidence of the presence of a molecular dispersion coexisting with a crystalline dispersion in the drug in the matrix. Similar results were obtained from X-ray diffractograms. In spite of 1:1 mPEG-PLA:P(3HB) blends having contributed to the reduction of the burst effect, a more controlled drug release was provided by the use of the 3:1 P(3HB):mPEGPLA blend. This result indicated that particle hydration played an important role in the drug release. On the other hand, the preparation of P(3HB):GEL composite microspheres did not allow control of the IBF release.
Important Factors in Drug Release Rate of Microspheres
2017
Small spherical particles with diameter range between 1μm to 1000μm referred to microsphere or microparticles. These systems can be generated by various methods. In this case, genomics, biotechnology and chemistry has been important role in improvement of more potent and specific therapeutics creation. In order to remove many problems associated to traditional methods of administration, controlled release drug delivery systems are being improved. Drug delivery systems such as microparticles, nanoparticles, and pellets as polymer based systems can encapsulate drug and release it at controlled rates for long periods of time. These systems present several potential advantages than to traditional methods of administration. Also, many factors can have effect on drug release rate by microspheres. Among these factors, microsphere producingmethod is prominent factor and release rates may be influenced by type of polymer used in microsphere producing and the way in which the polymer degrades...