A study of serum lipid profile in normal pregnancy and pregnancy induced hypertensive disorders: a case-control study (original) (raw)
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Study of Lipid Profile in Pregnancy Induced Hypertension
2008
INTRODUCTION : Comprehensive antenatal care should ensure a healthy pregnancy with An outcome of a healthy mother and a healthy fetus with a good birth weight. Birth weight is not only the indicator of the health of the new born child but also it Predicts the future health of the child. Low birth weight child is prone to suffer From diabetes, hypertension, and coronary vascular disorders in their later life. Pre eclampsia, a disease of pregnant women is one of the leading causes of Maternal and fetal morbidity and mortality and it occurs in 2-7% of all Pregnancies. The most important determinants of blood pressure are 1. Cardiac output, 2. Peripheral vascular resistance Even when cardiac output is increased7 during normal pregnancy there is a Relative decrease in blood pressure due to the decrease in peripheral vascular Resistance. But in PIH there is increased resistance which is brought about by 1. Increased response to vasopressors, 2. Altered lipid synthesis leading to decrease ...
Lipid Profile Changes in Pregnancy Induced Hypertension
Basrah Journal of Surgery
W e tested the hypothesis that the plasma lipid and lipoproteins concentrations are increased markedly in women with pregnancy induced hypertension (PIH) relative to women with uncomplicated pregnancy and that these lipids de crease postpartum and to clarify the relation of lipid profile changes with the severity of pregnancy induced hypertension. This study is a prospective, case-control study conducted at Basrah Maternity and Child Hospital extended through a period of 12 mo nths from the first of August 2000 till the first of August 2001. Pre-labor venous blood samples were collected for 90 women with pregnancyinduced hypertension and 110 women with normal uncomplicated pregnancy with an age range (16-40) years and gestational age range (34-42) weeks after 12 hours fasting. Venous blood samples were also collected from only 30 women with PIH and 30 women with normal uncomplicated pregnancy after 24-48 hours postpartum. Serum was analyzed for concentrations of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C). Pre-labor serum (TG), (TC), (LDL-C) and (VLDL-C) were increased in women with PIH relative to uncomplicated pregnancies respectively P value (<0.001). (HDL-C) concentration does not differ between studied groups (P = 0.1). Concentrations of all lipids decreased significantly (P value <0.001) in both groups within the first 24-48 hours postpartum. However the levels of these lipids remained higher in women with PIH but were statistically not significant. Serum triglyceride and VLDL concentrations but not total cholesterol, HDL-C and LDL-C were significantly higher in severe PIH group in comparison with mild PIH. There was no correlation between the age, parity and the lipid profiles changes in both groups. There was a positive correlation between each of the (TG), (TC), (LDL-C) and (VLDL-C). (HDL-C) does not correlate significantly with other different types of lipid. In conclusion, plasma lipids and lipoproteins but not HDL-C are increased in PIH relative to normal pregnancy and hypertriglyceridemia found in severely PIH may contribute to endothelial dysfunction in PIH.
Journal of Pharmaceutical Research International, 2021
Background: The most leading cause of perinatal and maternal deaths and morbidity in developed and developing countries like India is pregnancy related hypertensive disorders especially pre-eclampsia. PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes. Increased TG, low-density lipoprotein cholesterol (LDL-C), cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) concentrations leading to dyslipidemia was found in majority of the studies. Aim: The study aims to evaluate predictor like maternal sr. lipid profile in 2nd trimester in pregnancy related hypertensive disorders. Objective: To evaluate the occurrence of normal maternal and altered maternal serum lipid profile serum lipid profile in 2nd trimester of pregna...
Journal of Molecular and Genetic Medicine, 2013
Pregnancy-induced hypertension (PIH) is one of a major cause of maternal mortality. Serum lipid profile plays pivotal role in the regulation of normal blood pressure during pregnancy. The aim of our study was to evaluate the alteration of serum lipid profile during normotensive and hypertensive pregnancy. This case-control study was conducted among the pregnant women visiting Jinnah Hospital Lahore, Pakistan from September, 2012 to March, 2013. Total 200 participants were evaluated out of which 50 were normotensive pregnant women (28 ± 8 years) taken as a normal control group and 150 were enrolled as hypertensive (30 ± 6 years) study group. Average blood pressure for normotensive pregnant women was 115/75 whereas, for hypertensive pregnant women it was 148.45/95.40. The levels of different serum lipids were measured using respective analytical kits. Hypertension was directly associated with increased levels of serum TGs (161..64) as compared to that of normotensive pregnant women. The increased levels of TGs, TC, and LDL in hypertensive pregnant women were also correlated with significantly increased values of TC/HDL, TGs/HDL and LDL/HDL in hypertensive pregnant women. From the results of our study, it can be concluded that lipid profile plays their critical role in regulating blood pressure during pregnancy. Increased levels of TC, TGs, LDL and VLDL induced hypertension, whereas, HDL regulated the blood pressure to normal levels. This association may be significant in understanding the development of hypertension during pregnancy and may help in developing the strategies for prevention and treatment of PIH.
International Journal of Contemporary Medical Research [IJCMR], 2018
Introduction: The association of alteration of serum lipid profile in hypertension has been well established. In pregnancy, normally, the altered levels of serum lipid profile increase the risk of Pregnancy-induced hypertension (PIH) which is one of the major causes of maternal and fetal mortality. Therefore, the present study was designed to investigate the alteration in serum lipid profile in pregnant women and in women with PIH. Study aimed to record the levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL) and triglycerides (TG) in healthy pregnant women and women with pregnancy induced hypertension Material and Methods: 90 pregnant women were recruited for this study. An informed consent was taken from each patient. Lipid profiles were assessed using standard procedures. Data was analyzed using SPSS for Windows (version 17.0, SPSS Inc., Chicago, Illinois, USA). The data is presented descriptively and test for significance was done using the student t-test for continous data. Results: the serum lipid levels of TC, VLDL, LDL and TG in PIH women were found to be higher and were statistically significant while HDL value was not significant, as compared with the healthy controls. Conclusion: From the results of our study, it can be concluded that lipid parameters are increased in pregnancy induced hypertension which may be helpful in the prevention of complication caused by PIH.
2020
Background: Hypertension is the commonest medical disorder encountered during pregnancy with a reported frequency of 9.8% in general population. Though the exact cause is not yet known, a lot of factors have been found associated with pregnancy induced hypertension. One such factor is maternal serum dyslipidemia. However, in most of the previous studies, there was doubt about the possible association between maternal serum dyslipidemia and pregnancy induced hypertension. Aim: To determine the frequency of pregnancy induced hypertension among pregnant women visiting a tertiary care facility and to compare the serum lipid profile in normotensive and hypertensive pregnant women. Methods: This was a descriptive cross-sectional study conducted at the Obstetrics and Gynaecology department of Lahore Medical and Dental college and Ghurki trust teaching hospital, Lahore, between 1/01/2017 to 30/06/2017. 200 patients who presented in the outpatient’s department and fulfilledthe inclusion crit...
Study of serum lipid profile in pregnancy induced hypertension
Indian Journal of Clinical Biochemistry, 2006
Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL cholesterol level as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of the ratios of total cholesterol : HDL cholesterol and triglyceride : HDL cholesterol as well as diminuition of the ratio of HDL cholesterol : VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D, while eclamptic women showed significant elevation of LDL cholesterol : HDL cholesterol ratio in addition.
International Journal of Clinical Biochemistry and Research, 2021
Introduction: Hypertensive disorders complicating pregnancy is the one of the most common medical problem of pregnancy. Worldwide, hypertensive disorders in pregnancy causes complication in about 10-16% of pregnancies. High blood pressure in pregnant women is related with incidence of large placental infarct and decreased placental growth resulting in intra uterine fetal growth restriction and intrauterine death. Hypertension in pregnancy is diagnosed when blood pressure is 140/90 mm of hg or greater with proteinuria and edema after 20 week of gestation. Plasma lipid and lipoprotein (a) undergo both qualitative and quantitative changes during pregnancy. During the course of normal pregnancy, plasma triglycerides and cholesterol concentration rises by 200-400% and 25-50% respectively. An abnormal lipid profile is known to be strongly associated with atherosclerotic changes and has direct effect on endothelial dysfunction. In preeclampsia women, thromboxane rise more than in normotens...