Association of Helicobacter pylori infection with gastric carcinoma (original) (raw)
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Association of Helicobacter Pylori Infection and Gastric Cancer
Post-Graduate Medical Journal of NAMS, 2015
Introduction: Gastric cancer remains one of the most common cancers worldwide and the second leading cause of cancer mortality in the world. Helicobacter Pylori is a major risk factor. Early detection of infection and eradication therapy will probably reduce the incidence of stomach cancer. This study is carried out to see the association of the H. pylori infection in gastric cancer patients in our population. Methods: This is a prospective cross sectional descriptive study done in Gastroenterology unit, Department of medicine, National Academy of Medical Sciences, Bir Hospital. Patients who were suspected of cancer of stomach clinically as well as endoscopically,their thorough history was taken and demographic profiles like age, sex and geographic location were recorded. Similarly, symptoms, risk factors and endoscopic finding were recorded. Likewise, result of rapid urease test and histopathology results were documented. Results: Male patients were seen to be more frequently affec...
Journal of gastroenterology, 1997
We conducted a case-control study to examine the association of Helicobacter pylori infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies for Helicobacter pylori were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent of Helicobacter pylori-associated gastritis. The seroprevalence of Helicobacter pylori in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P < 0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69-5.33) and those with a precancerous condition (odds rati...
Association of Helicobacter Pylori Infection and Stomach Cancer
2015
Introduction: Helicobacter pylori (H. Pylori) as a primary etiological factor in carcinoma stomach. Associationof H. Pylori in gastric cancer has been documented to be in more than 50% of cases. In underdevelopedcountries, this association is shown to be much higher according to different studies. Methods: A prospective observational study of 40 consecutive cases of carcinoma stomach was under takenin surgical department of Shree Birendra hospital and Bir hospital, for a period of two years 2009 to 2011.Location and pathological types of the lesion were noted and all specimens were investigated to see presenceof helicobacter pylori by rapid urease test (RUT) and histological examination. Results: Out of 40 patients, helicobacter pylori positivity was seen in 27 (67.5%) cases by both rapid ureasetest and Histopathological examination (HPE). Regarding the pathological types, out of 26 intestinal type of castomach, 20 (76.92%) cases were positive for H. pylori infection, whereas out of...
[Helicobacter pylori infection in gastric cancer]
Nippon rinsho. Japanese journal of clinical medicine
The relationship between Helicobacter pylori (H. pylori) infection and gastric cancer becomes the topics in the world, since some reports thereon in 1991. The purpose of this study was to know the prevalence of H. pylori infection in many patients with gastric cancer. We examined the H. pylori IgG antibody in 507 patients with gastric cancer resected surgically in our hospital from 1989 to 1991, retrospectively. For the test of H. pylori IgG antibody, HM-CAP EIA kit (Italy, ENTERIC PRODUCTS Co.) was used. The overall detection rate of H. pylori IgG antibody was 75% (378/507). H. pylori infection was significant significantly frequent in early cancer (80%, 231/288) than advanced cancer (67%, 147/219). But, the other clinicopathological features such as sex, age, histological type, location and the degree of intestinal metaplasia were not significantly correlated with H. pylori infection. To evaluate the risk of H. pylori infection for gastric cancer, we are going to plan a matched-pa...
Clinicopathological Study of Gastric Carcinoma with Special Reference to Helicobacter pylori
Journal of Pure and Applied Microbiology
Gastric cancer (GC) is one of the most common malignancies. Although Helicobacter pylori (H. pylori) is being recognized as a Type I carcinogen for GC and primary gastric lymphoma (PGL), yet many studies especially from the Indian subcontinent do not show any such association. The aim of the study was to evaluate the clinicopathological characteristics of gastric adenocarcinoma and to determine the association of H. pylori infection. This prospective study included 50 cases of histologically proven gastric adenocarcinoma. A detailed clinical history, physical examination and upper gastrointestinal endoscopy were done in all the cases and mucosal biopsies were taken from the growth and the surrounding mucosa. Rapid urease test (RUT) was done to diagnose H. pylori infection. 50 patients of functional dyspepsia were taken as controls. GC was more common in males (70%). The maximum cases were recorded in elderly persons, mostly from 5 th to 6 th decades. Anorexia (60%), dyspepsia (54%) and weight loss (24%) were the commonest clinical presentation. Most of the patients presented within 3-12 month of onset of symptom. In majority of cases, the lesion was confined to the antrum (62%) and body (26%) of the stomach. H. pylori infection was more commonly isolated from the antrum. H. pylori infection was not significantly associated with GC as compared to patients with functional dyspepsia. No association was found between H. pylori infection and gastric carcinoma. Probably gastric cancer is multifactorial disease where dietary, genetic and environmental factors play contributing roles.
Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
2006
Helicobacter pylori is one of the most common infections in man. The infection is often acquired during childhood and usually results in a chronic life-long inflammation in the gastric mucosa. The aim of our studies was to investigate the association between H. pylori seropositivity and the development of gastric and oesophageal carcinomas. Nested case-control studies were performed in the Malmo Preventive Medicine cohort consisting of 32,906 subjects. Tumour cases were identified by the Swedish National Cancer Registry. H. pylori infection was identified serologically by an in-house ELISA and a commercial Western blot method, Helicoblot 2.1. The more virulent H. pylori cagA-positive strain was identified by the CagA band in Helicoblot 2.1. We found that H. pylori seropositivity was associated with a higher risk of non-cardia gastric adenocarcinoma. H. pylori seropositivity was a risk factor for non-cardia gastric adenocarcinoma among both smoking and non-smoking subjects. CagA sero...
Helicobacter PyloriInfection in Gastric Cancer: A Study of 84 Cases from Asir Region
Annals of Saudi Medicine, 1994
Gastric cancer can be divided into three histologic types: intestinal and diffuse adenocarcinoma, and malignant lymphoma. To determine whether Helicobacter pylori was associated with either cancer type, we reviewed histologic sections from stomachs of 84 patients with the diagnosis of gastric cancer. Of 63 patients with histologic evidence of intestinal adenocarcinoma, 53 (84%) contained H. pylori in noncancerous tissue compared with six (66.7%) of nine patients with diffuse adenocarcinoma (odds ratio = 2.65; Z= 1.048; P>0.05) and with eight (66.7%) of 12 patients with non-Hodgkin malignant lymphoma of the stomach (odds ratio = 2.65; Z=0.826; P>0.05). Our findings are compared with reported data from other countries and we are not aware of similar reports from the Kingdom of Saudi Arabia.