Bruton’s Tyrosine Kinase Inhibition for the Treatment of Rheumatoid Arthritis (original) (raw)
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
Heleen Scheerens
…, 2007
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Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures
Garth Ringheim
Frontiers in Immunology, 2021
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Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis
Vincent Hurez
Nature Chemical …, 2010
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The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells
Padmaja Magadala
Arthritis Research & Therapy, 2011
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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
Adam Johnson
Journal of medicinal chemistry, 2018
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Bruton’s Kinase Inhibitors for the Treatment of Immunological Diseases: Current Status and Perspectives
Ewa Robak
Journal of Clinical Medicine
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Kinase inhibitors: A new tool for the treatment of rheumatoid arthritis
George Kalliolias
Clinical Immunology, 2013
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Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy
Karin Reif
Journal of Pharmacology and Experimental Therapeutics, 2011
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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK)
Naiyu Zheng
Journal of Medicinal Chemistry
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Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease
Stephen White
The Journal of Immunology, 2021
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Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis
Jose Gómez-puerta
Current Topics in Medicinal Chemistry, 2013
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Kinase Inhibition — A New Approach to the Treatment of Rheumatoid Arthritis
David Fox
New England Journal of Medicine, 2012
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Tyrosine kinases as targets for the treatment of rheumatoid arthritis
Tamsin Lindstrom
Nature reviews. Rheumatology, 2009
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ZYBT1, a potent, irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer
Poonam Giri
Pharmacology Research & Perspectives, 2020
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A multitude of kinases--which are the best targets in treating rheumatoid arthritis?
Tamsin Lindstrom
Rheumatic diseases clinics of North America, 2010
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Selective Tyrosine Kinase Inhibition By Imatinib As a Novel Treatment Strategy for Rheumatoid Arthritis
Peggy Ho
Clinical Immunology, 2006
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The Importance of Bruton Tyrosine Kinase (BTK) and Targeted Therapies
Denise Jackson
Hematology & Transfusion International Journal, 2016
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Ibrutinib and novel BTK inhibitors in clinical development
Nikhil Mukhi
Journal of Hematology & Oncology, 2013
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Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
Allan Wissner
Bioorganic & Medicinal Chemistry Letters, 2011
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Acalabrutinib (ACP-196): A covalent Bruton tyrosine kinase (BTK) inhibitor with a differentiated selectivity and in vivo potency profile
Allard Kaptein
Journal of Pharmacology and Experimental Therapeutics
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Dual Targeting of Janus Kinase and Bruton’s Tyrosine Kinase: A New Approach to Control the Pathogenesis of Rheumatoid Arthritis
Fatima Ijaz
Pakistan Journal of Zoology, 2020
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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
Igor Mochalkin
Journal of Medicinal Chemistry, 2019
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The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Manner
Bernd Kinzel
The Journal of Immunology, 2011
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Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study
Douglas Hough
Rheumatology and Therapy
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Novel Bruton's tyrosine kinase inhibitors currently in development
Osmond D'Cruz
OncoTargets and Therapy, 2013
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The effect of JAK1/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib
Gabriella meszaros
Clinical and experimental rheumatology, 2019
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Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis
Lijun Xin
International Immunopharmacology, 2019
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Second-Generation Brutons Tyrosine Kinase Inhibitors
SArmen Sarkissian
2017
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