In Vivo Study of Chromosomal Instability in Lymphocytes of Radiotherapy Patients (original) (raw)

This study investigates the chromosomal instability (ChI) in lymphocytes of radiotherapy patients, specifically focusing on those with uterine cancer. Analyzing samples from ten patients, the research demonstrates a significant increase in chromosome-type aberrations and ChI in first mitosis lymphocytes post-treatment, with persistent effects observable a year later. The findings suggest a link between radiation therapy and the potential risk of second cancers due to transmission of chromosomal abnormalities in subsequent cell cycles.