Eosinophil cationic protein and eosinophil protein X in the nasal lavage of children during the first 4 weeks of life (original) (raw)

Eosinophil cationic protein (ECP) and eosinophil protein X (EPX) are established markers of eosinophil activation. This study analyzed ECP and EPX concentrations in nasal lavage fluids of 378 neonates over their first four weeks of life, focusing on those with parental allergy compared to controls. Results indicated statistically significant higher concentrations of ECP and EPX in the study group, suggesting early eosinophil activation in children with allergic parents, which may reflect a genetic predisposition to allergy or early allergen exposure.