Biological Dosimetry of Ionizing Radiation (original) (raw)

2012, Current Topics in Ionizing Radiation Research

Nevertheless, these bioindicators have many limitations. Currently, a lot of research is performed to find new indicators of exposure (such as H2AX and gene expression) (Figure 1). It is important to note that there are several essential requirements for biological parameters as meaningful dosimeters: low background level, clear dose-effect relationship for different radiation qualities and dose rates, specificity to ionizing radiation, noninvasive, fast availability of dose estimate, good reproducibility and comparability of in vitro and in vivo results (Romm, 2009). Gene expression profil γH2AX foci yield Dicentric Centric Ring Acentric fragment Micronucleus Centromere-positive Centromere-negative Micronucleus Micronucleus Unstable chromosome aberrations =Recent exposure Early variations Very early signalization Damage signalization modulation of gene expression Misrepair Stable chromosome aberrations =Old exposure Two-way One-way Insertion Translocation Translocation Gene expression profil γH2AX foci yield Dicentric Centric Ring Acentric fragment Micronucleus Centromere-positive Centromere-negative Micronucleus Micronucleus