Assessment of serum biomarkers of oxidative stress in patients with chronic renal failure (original) (raw)

Chronic renal failure (CRF) is becoming a major health challenges among worldwide. Incidence of the disease is alarming, because an insufficient therapeutic methods. Based on the estimated glomerular filtration rate (eGFR), the CRF is being classifying in to numerous phases. Recent guidelines classified the severity of CRF into 5 phases. First stage is being the mildest and fifth stage being a severe illness with less lifeexpansion.The present study was designed to assess the link between CRF and oxidative stress markers, urea, creatinine and serum creatinine levels in Patients with chronic renal failure.A total fifty CRF patients and fifty healthy control subjects were considered, based on the eGFR values patients were assigned to five phases. The results indicating that serum lipid peroxidation was significantly increased in all the phases of CRF patients when compared to the controls. Serum superoxide dismutase mean values are not showing any variation in first phase but, in later phases values were graduallydecreased as compared to control subjects. The study reinforce the possibility that antioxidant supplementation is helpful to CRF patents. It is extremely important to know oxidative stress in CRF patient right from the time of diagnosis is made. Efforts should be made to reduce oxidative stress by using antioxidant supplements and nutritional repletion.