A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2 (original) (raw)
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Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 1998
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Late Onsep multiple sclerosis : the LORSEP cohort
2008
Les formes à début tardif (après 50 ans) de scléroses en plaques (SEP) ont traditionnellement été considérées comme étant de mauvais pronostic, associées à des délais d'atteinte d'un handicap irréversible d'autant plus courts que la maladie débute tardivement. Il existe toutefois des facteurs confondants potentiels comme le sexe et surtout la forme évolutive. Nous avons voulu réévaluer l'importance pronostique de l'âge tardif au début de la maladie à partir de la cohorte lorraine des patients atteints de SEP (LORSEP). Les caractéristiques cliniques des SEP débutant après 50 ans dans la cohorte LORSEP semblent conformes aux données de la littérature, avec en particulier une surreprésentation de formes progressives primaires. En analyse univariée comme en analyse multivariée, l'âge tardif au début de la maladie, les formes de type progressif primaire et le sexe masculin sont prédictifs de l'accumulation rapide d'un handicap irréversible, dont témoignent...
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Revue d'épidémiologie et de santé publique, 2010
In France, the prevalence of multiple sclerosis is estimated between 65 and 125 patients per 100,000 inhabitants with a South-West towards North-East gradient. Nevertheless, the epidemiology of multiple sclerosis remains still imperfectly known, the recent studies being realized, either in a region of France, or from a single data source and thus suscepted not to be exhaustive. Assessing the prevalence of the multiple sclerosis in 2005 in Haute-Garonne by matching several data sources completed by a capture-recapture method; estimating the exhaustivity of each of the sources. The data sources were hospital data (DRG for the hospitalization, data of consultation), data of public health insurance system (main health insurance, agricultural health insurance, social welfare for self employed), and data from the MIPSEP network. The linkage was based on name, maiden name, first name, date of birth and sex and allowed a first estimation of the number of cases. Models of loglinear regressio...
CISD2, protéine à centre Fe-S impliquée dans différentes pathologies humaines
2021
CISD2 and mitoNEET are two NEET proteins anchored to organelle membranes with their Fe-S cluster in the cytosol. If we exclude their difference in subcellular localization (mitochondria for mitoNEET and ER for CISD2), these two proteins could appear to be very similar. Indeed, their cytosolic domain are close in sequence and structure. In the present study, combining cellular and biochemical approaches, we compared different characteristics of these two proteins in order to estimate if they could have comparable functions and mechanisms of action or even be redundant in the cell. Even if they share common characteristics including a high intrinsic stability and a sensitivity to oxygen, they differ in terms of their expression profile in tissues, their stability in the cell and the effect of pH on the stability and the transfer of their Fe-S cluster in vitro. Finally, we wonder about the possible involvement of CISD2 in cellular Fe-S cluster trafficking.
Journal of the American College of Surgeons, 2021
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[Interleukin 13 and interleukin 13 receptor involvement in systemic sclerosis]
La Revue de Médecine Interne
PURPOSE: Interleukin 13 is an immunoregulatory cytokine predominantly secreted by activated Th2 cells. It has similar functions with interleukin 4 and they share a common receptor. However, unlike interleukin 4, l'interleukin 13 does not appear to be important in the initial differentiation of CD4 T into Th2-type cells, but rather appears to be necessary in the effector phase of inflammation and fibrosis. This cytokine has been involved in recent works in allergic inflammation and in some fibrotic diseases leading to a scientific interest to analysis the role of interleukin 13 in systemic sclerosis (scleroderma). MAIN POINTS: Systemic sclerosis is an autoimmune disease characterized by vascular alteration and skin and visceral fibrosis. A genetic background associated with susceptibility is supposed. Knowing the profibrogenic properties of interleukin 13, we asked if polymorphisms located in interleukin 13 and interleukin 13 receptor genes could be associated with systemic scler...
[Approaches to segment multiple-sclerosis lesions on conventional brain MRI]
Different sets of criteria are currently used for the diagnosis of multiple sclerosis (MS). Some are based on clinical features, while others are related to imaging findings. Among the image processing systems, specific criteria include spatial dissemination of lesions in one image or their temporal dissemination in images acquired at different time points. In addition, the evolution of the lesion load can be used to evaluate treatment efficiency in MS clinical research. Consequently, obtaining a precise segmentation of the MS lesion appears to be crucial. In the literature, a number of semi-automated or completely automated approaches have been proposed enabling a reduction of the inter- and intra-expert variability for manual delineations. A comprehensive state-of-the-art classification of the most representative systems is presented here.
[BCcogSEP: a French test battery evaluating cognitive functions in multiple sclerosis]
Revue neurologique, 2004
In French language, there is no standardized procedure to assess cognitive function in patients with multiple sclerosis (MS). Such an assessment is however very useful to determine the consequences of the disease on cognitive function, to evaluate the disease progression and the consequences of usual treatments on cognition. This study aimed to develop and validate a French language battery based on "the Brief Repeatable Battery of Neuropsychological tests for Multiple Sclerosis" (BRB-N) often used in other countries. In an initial phase, the battery was composed of the French version of the 5 BRB-N tests to which were added 4 tests assessing immediate and working memory as well as executive function. 52 healthy control subjects (20-50 years) participated in the study. A principal component analysis (PCA) of their data examined the contribution of each test into the battery. 93 other healthy subjects participated in a second phase where analyses of variance were carried ou...