The Gcn5 Ada Complex Potentiates the Histone Acetyltransferase Activity of Gcn5 (original) (raw)
1998, Journal of Biological Chemistry
AI-generated Abstract
The Gcn5 histone acetyltransferase (HAT) is part of a multimeric complex critical for transcriptional activation in yeast, specifically through histone acetylation. This research highlights the essential role of the Ada2 subunit in potentiating the HAT activity of Gcn5, illustrating that mutated Gcn5 proteins, despite their reduced enzymatic function, can still operate effectively in the wild-type context when associated with Ada2. Kinetic analyses demonstrate that the presence of Ada2 significantly enhances Gcn5's acetylation capability, supporting the idea that the Gcn5·Ada complex is vital for proper chromatin remodeling and transcription regulation.
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