Novel Synthetic Routes to Prepare Biologically Active Quinoxalines and Their Derivatives: A Synthetic Review for the Last Two Decades (original) (raw)

Synthetic Development of Antimicrobial Novel Quinoxaline Derivatives

3.2.3. N-(4-Chlorophe nyl)-2,3-diphenylquinoxaline-6-sulfonamide (c): 0.65 g of 4-Chloro aniline was refluxed with 1.9 g of 2, 3-Diphenylquinoxaline-6-sulfonylchloride and 50 ml of 10% aq. NaOH solution for 1.30 hrs. Then reaction mixture was po ured into 10 ml. cold water and stirred until product crystallized then product was filtered and recrystalized by ethanol.

Fast and green synthesis of biologically important quinoxalines with high yields in water

Current Chemistry Letters, 2014

Optimal method were developed for the green synthesis of quinoxaline derivatives based on the highly efficient and simple condensation reaction of various aromatic 1,2-diketones and 1,2diamines in nearly quantitative yields in water. In this method we did not use any catalyst. The very mild reaction conditions, the high yields of the products, and the absence of any catalyst make this methodology an efficient and green route for synthesis of quinoxalines.

Synthesis, Reactions and Biological Activity of Quinoxaline Derivatives

American journal of organic chemistry, 2015

The review deals with synthesis and reactions of quinoxaline derivatives as well as their diverse pharmacological and biological properties. Quinoxalines and fused ring systems show diverse pharmacological activities. Syntheses of quinoxaline derivatives via many different methods of synthetic strategies have been presented.

A Review on Synthesis of Quinoline Analogs as Antimalarial, Antibacterial and Anticancer agents

2021

Numerous natural products possessing quinoline moiety exhibit interesting biological and pharmacological properties, such as antimalarial, antibacterial, antiasthmatic, antihypertensive, anti-inflammatory, immunosuppressive, antileishmanial, and anticancer activity. Surprising, quinoline scaffold has been used to synthesize antimalarial, antibacterial and anticancer drugs. This article provides update on the latest development in synthesis and biological evaluation of antimalarial, antibacterial and anticancer quinoline analogs. The new synthetic methodologies and the biological activities of the new quinoline analogs in the three areas were focused. Key words: antimalarial, antibacterial, anticancer and quinoline

Novel green approacches for synthesis of quinoxaline derivative

The objective of present research work is to provide green technique for synthesis of quinoxaline derivative. Quinoxaline derivatives are well known in the pharmaceutical industry and have been shown to possess a broad spectrum of biological activities. Highly efficient and simple methods have been described for the synthesis with excellent yields (95-98%). Present synthesis complies with principle of Green chemistry. As part of current studies, we here in reports efficient practical techniques like- sonication (sonochemistry sythesis), UV radiations and simple mortal-pastel method (mechanochemistry). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. The synthesized 2, 3- diphenyle quinoxaline was confirmed by physical constant ...

Sustainable Approaches Towards the Synthesis of Quinoxalines

The quinoxaline (Qx) nucleus is present in various bioactive molecules. Thus, synthesis of Qxs continues to draw the attention of synthetic organic/medicinal chemists. The contemporary interest in search for newer synthetic methods for this privileged class of compounds remains unabated and a vast number of publications continue to appear. The focus of this chapter is on the research works published in this area after the year 2000 with the inherent objective to attain sustainability towards the synthesis. The attention will be on the key sustainable approaches of pharmaceutical industries like the solvent-free reactions, use of alternate reaction media (e.g., water, fluorous alcohols, polyethylene glycols, and ionic liquids), and alternate modes of synthesis such as microwave-assisted synthesis and flow reactions.

Synthesis of Quinoline Analogues as Anti-microbial Agents

2015

Various substituted Quinoline containing different functional group have been synthesized by conventional method. The quinoline derivative is synthesized by using 8-hydroxy quinoline) was first treated with ethyl chloroacetate to form ester intermediate which was subsequently treated with Hydrazine Hydrate result into formation of Hydrazone derivative then this intermediate was made to react with substituted benzoic acid. The final structures have been established on the basis of their chemical analysis and spectral data. Final compounds were further evaluated for in-vitro anti-microbial activity using standards.