Problem Drinking in Women Evaluated for Infertility (original) (raw)
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Male alcohol consumption and fecundity in couples attending an infertility clinic
Andrologia, 2009
Semen paramctcr ~ fertility outcomc ~ alcohol consumptionhuman. Summary. The relationship between male alcohol intake and fertility was studied for 258 couples attending an infertility clinic. 2 1 "/, consumed less than 1 unit per week on average, 10% consumed between 1 and 5 units per week, 23% consumed between 6 and 10 units per week, 27% consumed 11 to 20 units per week and 19% consumed more than 20 units per week. There was no significant association between alcohol consumption and any semen parameter. 110 men had a female partner who was apparently normal. There was no significant difference in the alcohol intake between the 'normal' and 'abnormal' female groups. Couples were followed-up for up to 32 months. Sixteen women had a treatment independent conception within the 'normal' female group. There was no significant association between the amount of alcohol consumed per week and the fertility outcome.
Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization
Journal of Assisted Reproduction and Genetics, 2017
Objective The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF). Design This study is a retrospective cohort study. Setting This study was performed in a private academically affiliated IVF center. Patients Patients included women presenting for their first IVF cycle from July 2004 through October 2012. Intervention Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption. Women were categorized as nondrinkers, social drinkers, or daily drinkers, as well as by the number of drinks consumed per week. Competing risks analysis was used to calculate the cumulative incidence of live birth after 6 cycles stratified by alcohol consumption. Main outcome measures Main outcome measures included spontaneous abortion, clinical pregnancy, and live birth following IVF. Results There were 591 (27.7%) non-drinkers, 1466 (68.7%) social drinkers, and 77 (3.6%) daily drinkers (total n = 2134). In the first cycle, compared to non-drinkers, daily drinkers had a twofold increased risk of spontaneous abortion (adjusted risk ratio [aRR] 2.2; 95% confidence interval [CI] 1.1-4.5) among all cycle starts, and while their risk of live birth was 30% lower (aRR 0.7; 95% CI 0.4-1.3), the sample size was small, and it was not significantly lower. By the end of 6 cycles, social drinkers and daily drinkers did not differ from non-drinkers in their cumulative incidence of live birth (56.1, 50.6, and 52.1%, respectively; both P ≥ 0.28). Conclusion There was a trend towards lower risk of live birth among daily drinkers. Daily drinkers had an increased risk of spontaneous abortion in the first cycle, but the number of daily drinkers was small.
Effects of alcohol consumption on female fertility during an 18-year period
Fertility and Sterility, 2004
Objective: To investigate the long-term effects of alcohol consumption on female fertility. Design: Prospective study of a random sample of 7,393 women, selected from the 445,000 inhabitants of Stockholm County, Sweden, in 1969. Self-estimated alcohol consumption was obtained from postal questionnaires. Data on hospitalizations for pregnancy outcomes including infertility examinations were analyzed until 1987. Setting: Healthy women in Stockholm County, Sweden. Patient(s): Seven thousand three hundred ninety-three women in the age range 18-28 years. Main Outcome Measure(s): Rates of hospitalization for deliveries, miscarriages, legal abortions, extrauterine pregnancies, pelvic inflammatory disease, endometriosis, and infertility examinations were analyzed in relation to the intake of alcohol. Result(s): Two hundred fifty-two women underwent infertility examinations. High consumers had an increased risk for such examinations, as compared with moderate consumers: relative risk ratio (RR) ϭ 1.59 (95% confidence interval [CI]: 1.09-2.31); and low consumers had a decreased risk (RR ϭ 0.64; CI: 0.46-0.90). Moreover, for both high and low consumers we observed a significantly lower number of first and second partus. Rates of miscarriage, extrauterine pregnancy, and pelvic inflammatory disease did not differ between high and low consumers of alcohol. Conclusion(s): High alcohol consumption was associated with increased risk of infertility examinations at hospitals and with lower numbers of first and second partus. It may be important for the female partner in an infertile couple to limit alcohol intake or to not drink at all.
Infertility in women and moderate alcohol use
American Journal of Public Health, 1994
12 months of unprotected intercourse or the failure to deliver a live-born child. Case subjects were excluded if their infertility was due to congenital abnormalities, if they were seeking reversal of tubal ligations, or if their husbands had had vasectomies. Among the total number of case subjects who were eligible for interviewing, 5% refused, 10% were not interviewed due to a language barrier or other problem, 10% were lost to followup, and 10% had not completed their infertility work-up by the close of the study, leaving 1880 case subjects who were included. Work-ups in these subjects identified the following causes of infertility: ovulatory factor, tubal disease, cervical factor, endometriosis, male factor, or idiopathic infertility. Diagnostic protocols included, when indicated, measurement of basal body temperatures, hormonal studies, endometrial biopsies, postcoital test, hysterosalpingography, and diagnostic laparoscopy. We assigned each woman to one infertility category based on her most likely cause of infertility, as indicated by the evaluating physician, and designated this cause as the case subject's "first diagnosis." However, infertility is often a multifactorial disorder. In a previous publication, we described in detail the distribution of second diagnoses (accom-Methods it <Originally, this case-control study was undertaken from 1981 through 1983 :
Alcohol consumption and in vitro fertilization: a review of the literature
Gynecological Endocrinology, 2014
The aim of our study is to determine whether alcohol consumption affects the results of in vitro fertilization. A review of the literature was performed to find prospective cohort studies of couples undergoing in vitro fertilization in which alcohol intake was recorded. A primary search returned 389 studies, 2 of which were finally considered eligible. A total of 2908 couples were analyzed in terms of pregnancy outcomes depending on drinking habits. The risk of IVF failure increased 4.14-fold and 2.86-fold with an increased alcohol intake of 12 gr/d in women during the week and month before, respectively. The odds ratio (OR) of live birth rate in women who drank at least four drinks per week compared with women who drank fewer was 0.84; this difference was statistically significant. Paternal alcohol use levels 1 month, 1 week and during the attempts were also associated with worse reproductive effects. Our review, though including a small number of studies that were heterogeneous in design, revealed decreased rates of pregnancy and fertilization outcomes for couples who drank before or during their in vitro fertilization techniques. This suggests that couples undergoing IVF should be advised to abstain from alcohol prior to and during their procedures.
Clinical Medicine & Research, 2006
Background: Prenatal alcohol exposure is a leading cause of preventable mental retardation and developmental disabilities, including fetal alcohol syndrome. Current medical guidelines recommend that no alcohol should be consumed over the period of conception and throughout pregnancy. Although the majority of women reduce alcohol consumption when they realize they are pregnant, this recognition may not occur until well into the first trimester, potentially impacting embryonic development.
Article Alcohol and Difficulty Conceiving in the SUN Cohort: A Nested Case-Control Study
2016
The role of alcohol on fertility remains unclear. We aimed to investigate the association between alcohol and specific alcoholic beverages consumption and the risk of difficulty getting pregnant. We used a case-control study nested within the Seguimiento Universidad de Navarra (SUN) cohort, a prospective, dynamic and multipurpose cohort of 21,705 Spanish university graduates, followed biennially with mailed questionnaires. We identified 686 case-control pairs, matched for age and time in the cohort. Cases were women reporting difficulty getting pregnant. Controls did not consult due to difficulty conceiving and had at least one child during follow-up. After adjustment for potential confounders, we found no association between self-reported difficulty getting pregnant and the number of alcoholic beverages consumed per week, (Odds Ratio [OR] > 5 drinks/week vs. none = 1.04, 95% Confidence Interval [CI] = 0.72-1.51). No association between types of alcoholic beverage and difficulty conceiving (OR > 5 drinks of wine/week vs. none = 1.16, 95% CI = 0.72-1.88; OR > 5 drinks of beer/week vs. none = 1.06, 95% CI = 0.82-1.37; OR > 5 drinks of spirits/week vs. none = 1.24, 95% CI = 0.84-1.64) was observed. In conclusion, we found no association between alcohol intake and risk of consulting a Nutrients 2015, 7 6168 physician due to difficulty conceiving. More studies are needed to clearly elucidate the effects of alcohol intake on women's fertility. In the meantime, recommendations about alcohol intake to couples trying to conceive have to be given cautiously.
Alcohol Consumption at the Time of Conception and Spontaneous Abortion
American Journal of Epidemiology, 2004
The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions in Denmark in 1992-1994, 430 couples without previous pregnancy attempts were enrolled when birth control was discontinued, and they were followed until a clinically recognized pregnancy or for six menstrual cycles. Alcohol intake and potential confounding factors were reported in monthly questionnaires. Women collected morning urine for 10 days from the first day of vaginal bleeding in each cycle. The authors detected 186 pregnancies: 131 resulted in childbirth, and 55 resulted in spontaneous abortion (34 detected by urinary human chorionic gonadotropin). Depending on the intake in the cycle of conception and the adjustment factors, female alcohol intake was associated with 2-3 times the adjusted risk of spontaneous abortion compared with no intake, and male alcohol intake was associated with 2-5 times the adjusted risk. Only the adjusted relative risks for 10 or more drinks/week compared with no intake were statistically significant. Both male and female alcohol intakes during the week of conception increased the risk of early pregnancy loss. abortion, spontaneous; alcohol drinking; embryo; follow-up studies Abbreviation: hCG, human chorionic gonadotropin.
The association between alcohol intake and fecundability during menstrual cycle phases
Human Reproduction, 2021
STUDY QUESTION Is increased alcohol intake in different phases of the menstrual cycle associated with fecundability in women? SUMMARY ANSWER Heavy intake (>6 drinks/week) of alcoholic beverages in the luteal phase and ovulatory subphase was associated with reduced odds of conception; moderate intake (3–6 drinks/week) during the luteal phase was also associated with reduced fecundability. WHAT IS KNOWN ALREADY Despite strong indications for increased risk of infertility among drinking women with intention to conceive, inconsistencies in previous results point to possible residual confounding, and have not thoroughly investigated timing of drinking and other drinking patterns during the menstrual cycle. STUDY DESIGN, SIZE, DURATION Participants in The Mount Sinai Study of Women Office Workers (MSSWOW), a prospective cohort study of fertility, were recruited and followed between 1990 and 1994, and completed daily diaries reporting their alcohol intake (type and number of drinks) for...