Spilanthes acmella ethanolic flower extract: LC–MS alkylamide profiling and its effects on sexual behavior in male rats (original) (raw)
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BMC complementary and alternative medicine, 2004
The flower bud of Syzygium aromaticum (L.) Merr. & Perry. (clove) has been used in Unani medicine since ancient times for the treatment of male sexual disorders. The present study is aimed to investigate the effect of 50% ethanolic extract of clove on general mating behaviour, libido, potency along with its likely gastric ulceration and adverse effects on sexually normal male albino rats. The suspension of the extract was administered orally at the dose of 100, 250, and 500 mg / kg, to different groups of male rats (n = 6) once a day for seven days. The female albino rats involved in mating were made receptive by hormonal treatment. The general mating behaviour, libido and potency were determined and compared with the standard reference drug sildenafil citrate. The probable gastric ulceration and adverse effects of the extract were also evaluated. Oral administration of the extract significantly increased the Mounting Frequency, Intromission Frequency; Intromission Latency, Erection...
2021
Lecildo Lira Batista1,2, Lucas Corrêa do Nascimento2, Gabriel Francisconi Guimarães2, Arlindo César Matias Pereira1, Rosemary De Carvalho Rocha Koga1, Abrahão Victor Tavares De Lima Teixeira Dos Santos1, Caio Pinho Fernandes1, Thiago Afonso Teixeira2,3,4, Yutao Hu5, Xuebo Hu6, José Carlos Tavares Carvalho1,* 1Drugs Research Laboratory, Federal University of Amapá, Rodovia Juscelino Kubitisheck, Macapá, Amapá, BRAZIL. 2Division of Urology, School of Medicine, Federal University of Amapa, AP, BRAZIL. 3Men’s Health Study Group, Institute for Advanced Studies, University of São Paulo, SP, BRAZIL. 4Androscience, Science and Innovation Center in Andrology and High-Complex Clinical and Research Andrology Laboratory, SP, BRAZIL. 5Lianyungang TCM Branch of Jiangsu Union Technical Institute, Lianyungang, CHINA. 6Laboratory of Drug Discovery and Molecular Engineering, College of Plant Science and Technology, Huazhong Agricultural University, 1 Shizishan, Nanhu, Wuhan, CHINA.
Effect of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew on Sexual Behavior of Male Rats
Advances in Pharmacology and Pharmacy, 2018
Capparis decidua has traditionally been recommended as an aphrodisiac agent. Although, it's medicinal use has not been scientifically proved. The present study therefore evaluated the effects of hydroalcoholic extract of C. decidua roots, stem and leaf on sexual behavior in normal male rats. The hydroalcoholic extract of C. decidua was administered (100 mg/kg, 200mg/kg) to different groups of male wistar rats for 28 days. The female rats were brought in estrous phase before the mating in each group of male rats. Standard group was administered sildenafil citrate at 5mg/kg orally for 28 days. Control group was administered only distilled water. All the experimental groups i.e C. decidua 100mg/kg, 200 mg/kg, per se group (only C. decidua 200 mg/kg), standard group(sildenafil citrate 5mg/kg) were compared with the control group for parameters evaluated for sexual behavior study. C. decidua at 100mg/kg, 200 mg/kg, and per se treated groups produced significant arousal of sexual activity in male rats. They significantly increased the frequencies of mount, intromission frequency. The mount latency and intromission latency were significantly reduced but ejaculation latency was prolonged significantly. The results indicated that hydroalcoholic extract of C. decidua enhanced sexual behaviour in male rats. The enhanced sexual behavior in male rats at the doses of 100 and 200 mg/kg body weight may be due to the presence of phytochemicals like alkaloids, saponins, flavonoids as these phytochemicals has role in increasing sexual strength, androgen enhancing, and antioxidant activity.