β-catenin signalling pathway by the triterpene ursolic acid induced intrinsic apoptosis in human soft tissue sarcomas (original) (raw)

Abstracts / Chemistry and Physics of Lipids 163S (2010) S22-S33 S27 estimated to be about 0.2, assuming that the surrounding matrix consists of pure DPPC. According to the above assumption, density of the Cer-rich domain was calculated to be 1.014 g/mL from the densities of the bilayers containing less than 10 mol% Cer. The calculated density was between those of the gel and fluid phases and insensitive to the Cer concentration. Furthermore, electron microscopic observation of DPPC/Cer (<10 mol%) bilayers showed flat surfaces between normal ripple structures as seen in pure DPPC bilayers. These results supported the lateral coexistence of Cerrich sub-micron domains (probably in the liquid ordered L o phase) with nearly pure DPPC domains. Thus, even a small fraction of Cer facilitates the formation of L o phase through phase separation.