Determination of the expression of lymphocyte surface markers and cytokine levels in a mouse model of Plasmodium berghei (original) (raw)

This study investigates the changes in lymphocyte surface markers and cytokine levels in a murine model of malaria induced by Plasmodium berghei. The analysis revealed statistically significant reductions in lymphocyte surface markers among infected mice compared to healthy controls, alongside marked increases in several pro-inflammatory cytokines, except for transforming growth factor-beta (TGF-1β), which showed no significant difference. These findings suggest that immune responses, particularly T, B, and NK lymphocyte activity, are inhibited during malaria infection, highlighting the potential benefit of enhancing Th1 lymphocyte responses in malaria prevention.