Pseudomonas aeruginosa infection in human immunodeficiency virus infected patients (original) (raw)

Infectio mmunodeficienc 'Sel-vim des Maladies InJectieuses el Tropicales and 'Service de Rnctdriologie-l7iI-ologie. H@ital Saint-Antoine. 75022 Paris, aid 31LNSERM U 444. Facdte' de M&cine Saint-Antoine, Paris, Frmce 017jectives: (1) To determine the incident e and outcome of ~se~1do~~7oi7~s ~er~,~~~~~os~ infection in HIV-infected patients. (2) To study the antimicrobial susceptibility of R aerlaginosa isojlates in this particular ~o~nIatio~. (3) To iden-tifJr risk factors for these infections. Patients and Methods: a retrospective case-control study performed in a 2%bed infectious-diseases unit in a 94Q-bed university hospital. AII cases were defined as IIIV-infected patients with severe infections due to E aenrginosa, including bacteriemia, lower or upper respiratory tract infections, infections related to a central venous catheter, and cutaneous/muscular infectioil. Each case was mate ed with au NIV-seropositive control not infected by El aer~@rosn an hospitalized ou the same dates as the cases. Resrd~~: one thousand and thirty-five HIV-infected patients were B-rospitalized during the study period. A. First severe E? creruginosn infection was documented in 41 patients , giving an overaIl annuai iucideuce note of 2.5 1 episodes per 100 admissions. Forty of the 41 case notes were available for analysis. They consisted of 17 cases of bacteraemia, four