Osteonecrose de mandíbula em pacientes com lúpus eritematoso sistêmico juvenil observada em exame de imagem (original) (raw)
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Periodontal findings in systemic lupus erythematosus patients and healthy controls
Saudi medical journal, 2015
To compare periodontal findings in systemic lupus erythematosus (SLE) patients and healthy controls, and to determine, whether there is a correlation between periodontal parameters and SLE biomarkers. This cross-sectional study was conducted in the Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between November 2012 and February 2014. Twenty-five participants diagnosed with SLE and 50 healthy controls were selected. Periodontal assessment consisted of clinical attachment level (CAL), probing depth (PD), bleeding on probing, and plaque scores. For the SLE group, several laboratory tests were obtained, such as, white blood cell count, hemoglobin level, platelet count, anti-nuclear antibody, anti-double-stranded DNA antibody, calcium level, and vitamin D. Periodontal findings in SLE patients and controls were not significantly different. The SLE patients who had no flare-ups for more than a year showed significant bleeding on probing and deeper PD comp...
Zanjan University of Medical Sciences, 2023
Background and Objective: Due to the overall wide range of oral manifestations and the lack of comprehensively categorized information in Iran, this study was performed to investigate the prevalence of different oral manifestations and report their possible associated factors in patients with SLE. Materials and Methods: This cross-sectional study was performed on 96 SLE patients referred to two rheumatology clinics in Yazd, Iran, from September 2020 to February 2021. SLE patients were diagnosed based on the last revision of American College of Rheumatology (ACR) criteria in 1997. A questionnaire was created to collect demographic information and oral health status. Data were analyzed using SPSS v20.0 and p-values of P < 0.05 were considered statistically significant. Results: This study included 13 men (13.5%) and 83 women (86.5%), with an average age of 31.9 ±11.35 years. Oral lesions were diagnosed in 64.4% of patients, with white and red lesions being the most frequent (58%), and the most common region involved was buccal mucosa (25.8%). 97.1% of participants had caries and 86.5% had periodontal diseases. There was a significant association between the presence of oral lesions and female gender, longer duration and higher activity level of the disease and simultaneous presence of periodontal disease and missing or filled teeth. (P < 0.05). Conclusion: Given the frequency of oral lesions in more than 60% of patients, as well as the high incidence of caries and periodontal disorders, regular oral examinations in these patients appear to be particularly important. Keywords: Oral health, Oral lesions, Lupus Erythematosus
Oral manifestations of systemic lupus erythematosus
British Journal of Oral and Maxillofacial Surgery, 1997
The purpose of this pilot study was to assess the prevalence of oral manifestations among systemic lupus erythematosus (SLE) patients in Qatar, in order to warrant future studies that would investigate each one of these manifestations with detail and further scrutiny. Methods. Study procedures took place between November 2014 and April 2016. All patients visiting the outpatient rheumatology clinics at Hamad General Hospital, Doha, Qatar, were asked to join. The American College of Rheumatology (ACR) 1997 criteria of SLE were used. The patients were examined initially by a rheumatologist and were later scheduled for an appointment with a dentist at the same institution. A total of 77 patients were recruited for the study. Results. Prevalence rates for the different oral manifestations ranged from 2.4% for soft palate ulcers, cheilitis, and oral candida to 88.1% for the presence of cavitation. Gingivitis, periodontal disease, cavities, and missing teeth were observed in more than 50% of the sample. The prevalence of periodontal disease and missing teeth was higher among those with an SLE duration > 8 years. On the contrary, the prevalence of gingivitis and cavities was higher among those with an SLE duration ≤ 8 years. Conclusion. This study found high rates of gingivitis, periodontal disease, cavities, and missing teeth among SLE patients in Qatar. It is recommended that healthcare providers of such patients monitor the presence of any oral manifestations in order to arrange for early treatment and prevention efforts. Future prospective longitudinal studies with adequate sample size and power are needed in order to ascertain any causation factors or common etiology pathways.
Oral manifestation of systemic lupus erythematosus : A case report
2018
Systemic lupus erythematous (SLE), one of the rare dermatoses shows desquamative lesions as the oral manifestation Periodontal disease and SLE are both multifactorial conditions that share several pathogenic characteristics. The similar mechanisms of tissue destruction for periodontitis and other autoimmune diseases have stimulated the study of potential associations between these conditions. Hence, in the present study we present a case of a 70-year-old female suffering from SLE with oral manifestations.
Oral Manifestation of Systemic Lupus Erythematosus
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017
Background: Periodontitis worldwide reported increasing 57.3% between 20 years also reported 6 th most prevalence disease around the world. Imune response abnormalities, hyperactivity of production of autoantibodies deposited in human tissue and organ could affect oral cavity condition. Objectives: To find oral manifestation on SLE patients and correlate with SLE severity. Methods: Subjects were 61 patients with SLE (age 17-51 years; diagnosed using SLICC) collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Oral Manidestation is measured by clinical examination and SLE severity measured using SLEDAI. Result: A total 61 SLE subjects were included in this study. We found that 54 patients (88,53%) subjects with SLE had periodontitis. 7 subject had no periodontitis, 11 mild periodontitis, 43 severe periodontitis. There is correlation between oral condition and SLE severity. Periodontitis and SLEDAI score showed significant (p<0.0001) and strong positive correlation (r=0.948) Discussion : Our study found high rates of gingivitis, periodontitis, bop, low plaque index, and low calculus index. SLE is chronic autoimmune disease develop autoantibodies and immune complexes, because of immune respon abnormalities.It could be forming autoantibodies cause DNA damage, lipid peroxidation, protein. This condition induce collagen breakdown, RANKL, osteoclast stimulation until alveolar bone resorption resulting poor oral condition and periodontitis. Conclusion: Our study showed that oral condition were associated with SLE disease activity
Lupus Erythematosus: Considerations for Dentistry
The Journal of the American Dental Association, 1998
Lupus erythematosus, or LE, is commonly referred to as a collagen vascular, or connective, tissue disease. It is a vast disease affecting a number of organ systems. Affected patients are at increased risk of experiencing bleeding, infection, endocarditis, adrenal insufficiency and mucocutaneous disease, 1-8 all of which can affect the provision of dental care. More than 1.5 million people have been diagnosed with LE in the United States. 4,6,7 Dental care providers need to identify these patients, understand the complications associated with these conditions and their implications for dental therapy, and establish appropriate modifications of outpatient dental care. This article provides an overview of the pathogenesis and medical management of LE, as well as dental considerations for patients with this condition. PATHOGENESIS LE is believed to arise partly from aberrant immune behavior; the term "autoimmune" is used to describe the reaction of a person's own antibodies (autoantibodies) developed against his or her own tissue. The autoantibodies in LE could be the actual pathogenic agent of tissue destruction, the resultant consequence of tissue damage or the trace left by a true etiologic agent. 1 These immune complexes set off an array of immunological reactions, resulting in activation of the complement system, which attracts neutrophils and macrophages; this in turn leads to vasculitis, fibrosis and tissue necrosis. Recent developments suggest that LE could involve defects in apoptosis, or programmed cell death, leading to an impairment in the body's ability to eliminate unnecessary, damaged or potentially harmful cells. Systemic lupus erythematosus, or SLE, is a chronic, multisystemic disease of unknown etiology. It is characterized by the production of autoantibodies and immune complexes leading to protean systemic manifestations. The clinical course of SLE is marked by periods of remission and exacerbation. Ninety percent of those affected are young-to-middle-aged women, although it has been reported in men, children and older people. 4 Genetic, hormonal, racial and environmental factors all contribute to SLE. Specifically, SLE occurs more frequently in patients who have human leukocyte anti
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2021
Objective: To analyze periodontal comparison between Systemic Lupus Erythematosus (SLE) subject and healthy control. Material and Methods: This descriptive cross-sectional study included 122 subjects, 61 SLE patients and 61 healthy subjects who visited the Rheumatology Department, Dr. Saiful Anwar General Hospital, Malang, during 2017-2018. Clinical examination of SLE was using Mexican SLE Disease Activity Index and oral cavity conditions were assessed using the periodontal index, gingival index, calculus index, bleeding on probing, clinical attachment loss and mobility teeth. Results: The age of SLE patients ranged from 18-55 years old with the mean age of 29.50 ± 9.57 years old. Periodontitis was higher in SLE patients (88.5%) than healthy subjects (22.95%). In addition, periodontitis occurrence in SLE (2.66 ± 1.02) was significantly different (p<0.001) compared to healthy subjects (0.51 ± 0.81). Conclusion: This study found higher rates of periodontitis, gingivitis, bleeding on probing, clinical attachment loss, and mobility tooth among SLE patients compared to healthy subjects. Periodontitis was also found to be higher along with more severe SLE group.
Oral Manifestation on Systemic Lupus Erythematosus Patients
International Journal of Public Health and Clinical Sciences, 2019
Background: Periodontitis worldwide reported increasing 57.3% between 20 years also reported 6 th most prevalence disease around the world. Imune response abnormalities, hyperactivity of production of autoantibodies deposited in human tissue and organ could affect oral cavity condition. Objectives: To find oral manifestation on SLE patients and correlate with SLE severity. Methods: Subjects were 61 patients with SLE (age 17-51 years; diagnosed using SLICC) collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Oral Manidestation is measured by clinical examination and SLE severity measured using SLEDAI. Result: A total 61 SLE subjects were included in this study. We found that 54 patients (88,53%) subjects with SLE had periodontitis. 7 subject had no periodontitis, 11 mild periodontitis, 43 severe periodontitis. There is correlation between oral condition and SLE severity. Periodontitis and SLEDAI score showed significant (p<0.0001) and strong positive correlation (r=0.948) Discussion : Our study found high rates of gingivitis, periodontitis, bop, low plaque index, and low calculus index. SLE is chronic autoimmune disease develop autoantibodies and immune complexes, because of immune respon abnormalities.It could be forming autoantibodies cause DNA damage, lipid peroxidation, protein. This condition induce collagen breakdown, RANKL, osteoclast stimulation until alveolar bone resorption resulting poor oral condition and periodontitis. Conclusion: Our study showed that oral condition were associated with SLE disease activity
GSC Advanced Research and Reviews
Introduction. Systemic lupus erythematosus (SLE) is an autoimmune disease that includes a broad spectrum of mucocutaneous manifestations. Objectives. To characterize the clinical spectrum of oral mucosal lesions in patients with SLE and to analize their association with clinical and laboratory parameters. Methods. We performed a cross-sectional study with systematic oral evaluations in SLE adult patients. Systemic and cutaneous lupus activities were recorded. We collected epidemiologic, clinical, and laboratory data. Statistical analysis included the kappa coefficient, X2 test, Fisher’s exact test and Mann-Whitney U-test, adjusting for multiple comparisons according to Bonferroni’s method. Results. A total of 181 patients (92.8% females) were included, with a median age of 37 (range 16-76) years. Cutaneous, systemic, and oral manifestations of lupus erythematosus (LE) activity were found in 31.5%, 23.8% and 18.8% of patients, respectively. Higher titres of anti-double-stranded (ds) ...
Oral manifestations of patients with lupus erythematosus
Dental Clinics of North …, 2005
1. Dent Clin North Am. 2005 Jan;49(1):127-41, ix. Oral manifestations of patients with lupus erythematosus. Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Department of Oral Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28232, USA. ...