IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program (original) (raw)

The regulation of intracellular calcium (Ca2+) levels is essential for T cell activation, with inositol 1,4,5-trisphosphate (IP3) playing a crucial role in initiating Ca2+ release through IP3 receptors (IP3Rs). While the focus has primarily been on calcium release-activated calcium (CRAC) channels, the involvement of IP3Rs in cytokine production by naive CD4 T cells has not been fully explored. This study reveals that IP3R-mediated Ca2+ release is vital for the early production of pro-inflammatory cytokines IL-2 and IFN-γ, while concurrently repressing IL-17 production through the down-regulation of IP3R3 expression upon T cell activation. The findings underscore the significance of understanding IP3R contribution in T cell cytokine signaling and its implications for immune responses.