Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF (original) (raw)

The study investigates the effects of BAFF deficiency in lupus-prone New Zealand Mixed 2328 mice, revealing a counterintuitive outcome where the absence of BAFF leads to serological autoimmunity and renal pathology despite a lack of overt clinical disease. The findings indicate that while BAFF deficiency affects B cell development and autoantibody production, it does not prevent kidney damage or clinical disease manifestations, suggesting complexities in the role of BAFF in lupus pathology and implications for BAFF antagonist therapies in human systemic lupus erythematosus.