The Relationship between Serum Adiponectin Levels with the Presence and Severity of Coronary Artery Disease (original) (raw)

In a cross-sectional study, a total of 240 persons who referred to Shahid Faghihi and Nemazee Hospitals for coronary angiography were entered consecutively into the study. Exclusion criteria were: no history of coronary artery bypass graft (CABG) surgery or angioplasty, renal failure, and absence of any acute inÀammatory conditions that included infections, trauma or fever. After obtain-Abstract Background: Adiponectin plays important roles in the endocrine and cardiovascular systems, in fat and carbohydrate metabolism, and inÀammation. In this study the relationship between adiponectin levels with the presence and severity of coronary artery disease (CAD) is evaluated. Methods: This was a cross-sectional study that enrolled 213 persons who referred for coronary angiography. One cardiologist reported the results of each coronary angiography by using two scoring systems [number of vessel disease (usual method) and Gensini scoring system]. Then, the relationship between adiponectin levels with the presence and severity of CAD as well as predictive factors for CAD were evaluated. Results: There was a signi¿cant negative association between mean serum adiponectin levels and presence of CAD (P = 0.04) after adjustment for all conventional risk factors for CAD. Also there was a signi¿cant negative correlation between serum adiponectin levels and severity of CAD based on the usual method for reporting coronary angiograms (P = 0.01). After adjustment for all conventional risk factors for CAD the serum adiponectin level tended to be inversely associated with the Gensini score (P = 0.09). Logistic regression analysis showed that a higher serum adiponectin level was negatively and independently associated with CAD (odds ratio: 0.94; 95% con¿dence interval: 0.88-1.00; P < 0.05). The variables predictive of serum adiponectin levels were determined as follows: HDL-cholesterol (P = 0.001); age (P = 0.002); insulin resistance (P = 0.005) and triglycerides (P = 0.036). Conclusions: This cross-sectional study showed a signi¿cant negative association between serum adiponectin levels to the presence and severity of CAD.