The Relationship between Serum Adiponectin Levels with the Presence and Severity of Coronary Artery Disease (original) (raw)
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Clinica Chimica Acta, 2006
Background: Adiponectin, the most abundant adipocytokine of adipose tissue cells, has recently been found to be decreased in coronary artery disease (CAD). Data concerning adiponectin in different stages of CAD are rare, and it was not investigated if adiponectin levels are influenced by the severity of angina pectoris. Methods: Thus, we measured adiponectin serum levels by means of ELISA in 1626 male probands, including 273 control subjects, 367 subjects with silent CAD, 608 patients with stable, and 378 patients with unstable angina. Results: As compared to controls (8.56; 5.85 to 12.85 Ag/ml) and subjects with silent CAD (8.60; 5.99 to 12.64 Ag/ml), adiponectin was significantly decreased in patients with stable (7.22; 5.06 to 10.41 Ag/ml; p < 0.001 for both) and unstable angina (6.72; 4.08 to 10.08 Ag/ml; p < 0.001 for both). By a logistic regression analysis, low adiponectin levels were identified as a significant independent predictor for stable and unstable angina ( p < 0.001 for both). No significant differences of adiponectin were observed, neither between the stable and unstable angina group, nor between any classes of angina according to the Canadian Cardiovascular Society (CCS) Angina Score for stable angina. Conclusions: These results suggest, that decreased adiponectin levels are indicative for symptomatic CAD, but are not further influenced by the progression of this disease. D
The journal of Tehran Heart Center, 2013
The existing evidence suggests that plasma adiponectin concentrations can be indicative of the presence and severity of coronary artery disease (CAD). However, the results of the studies conducted hitherto on this subject are inconsistent. We sought to investigate the possible correlation between plasma adiponectin levels and the presence and severity of CAD in patients undergoing non-urgent coronary angiography. In 399 consecutive patients undergoing non-urgent coronary angiography for CAD survey, plasma adiponectin, triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein cholesterol, and fasting blood sugar levels were measured and demographic characteristics such as age, sex, Body Mass Index, diabetes mellitus history, systemic hypertension history, and family history of CAD were collected. According to the angiography results, the patients were divided into two groups of CAD and non-CAD. The severity of coronary atherosclerosis in the CAD group was ...
Relationship of Plasma Adiponectin and Waist-hip Ratio with Coronary Artery Disease
Medical Archives, 2016
Background: This study aimed to investigate correlation between adiponectin and waisthip-ratio with severity of coronary artery disease (CAD). There is uncertainty about the association between circulating concentrations of adiponectin and CAD. Methods: We enrolled eighty-two consecutive patients undergoing non-urgent coronary angiography for CAD survey. According to the angiography results, the patients were divided into two groups in 1:1 ratio patients admitted with a diagnosis of CAD and non-CAD. We conducted hospital based research, involving study group with documented angiographically CAD, and control group without evidence of CAD. Angiograms were also quantified for the extent and severity of CAD by the Gensini scoring system. We measured baseline adiponectin levels in stored serum samples of all patients, anthropometric and biochemical risk factors were assessed in both groups. Results: The presence of CAD was associated with current smoking, male gender, waist-hip ratio (WHR) and left ventricular ejection fraction (LVEF). Baseline adiponectin concentrations correlated significantly in terms of the lipid parameters, positively with HDL cholesterol concentrations (r=0.327, P=0.028, P<0.05) and serum triglyceride concentrations were correlated negatively (r=-0.513, P<0.001). No significant difference between median adiponectin levels at baseline was observed between cases and controls. Conclusion: There is a significant positive correlation between waist-hip ratio and presence and severity of coronary artery disease. In conclusion, there is a significant positive correlation between adiponectin and Gensini score among Kosovar patients.
Serum adiponectin levels in patients with coronary artery disease
Journal of Ayub Medical College, Abbottabad : JAMC
Adiponectin is an adipocytokine secreted from white adipose tissue. Serum level of adiponectin has been shown to be reduced in several disease states like obesity and diabetes. Hypoadiponectinemia has also been included in the list of newer risk factors for Coronary Artery Disease (CAD). In this analytical cross-sectional study serum adiponectin level was measured by Enzyme Linked Immunosorbant Assay (ELISA) in 60 cases of coronary artery disease (CAD) (both sexes, aged 40-60 yrs) and 60 healthy controls. Low levels of adiponectin were seen in CAD patients as well as controls. These levels were lower as compared to western standards. Our study conforms to the previous observation of lower serum adiponectin levels in South Asians compared to the western standards. Serum adiponectin level should be considered in the laboratory work-up of CAD patients.
Adiponectin: An Emerging Cardiovascular Risk Factor. The REFERENCE Study
Revista Española de Cardiología (English Edition), 2008
Emerging cardiovascular (CV) risk factors such as adiponectin, glycosilated hemoglobin, waist circumference and the high-sensitivity C-reactive protein (hsCRP) level can aid CV risk stratification. It has been shown that classic factors alone are not sufficient to explain CV risk fully. The adiponectin level has been linked to insulin resistance, dyslipidemia and coronary artery disease. This study investigated how the levels of adiponectin and other emerging risk factors are related to CV events in the Spanish population. This cross-sectional study involved 999 patients. They were divided into cases, who had experienced a first CV event in the 3 months prior to the study, and controls. Anthropometric and laboratory parameters recorded both after the event and 3 years before the study started were obtained. Both a low adiponectin level and a high hsCRP level were associated with the occurrence of a CV event. In addition, obesity and a triglyceride level &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = 150 mg/dL, both observed 3 years before the study, were also associated with the occurrence of an event. There was an inverse relationship between the plasma adiponectin level and waist circumference. Multivariate analysis identified the following significant variables: hsCRP level, a family history of early CV disease and the high-density lipoprotein cholesterol (HDL-C) level 3 years earlier. A low adiponectin level is associated with abdominal obesity. Emergent risk factors do not improve the predictive ability of the Systematic Coronary Risk Evaluation (SCORE) algorithm (which includes total cholesterol, HDL-C, blood pressure and smoking). Further studies evaluating their contribution are needed.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2009
Decreased serum adiponectin levels have been shown in patients with coronary artery disease (CAD). We evaluated the association between serum adiponectin levels and CAD severity on the angiogram. The study included 86 patients (70 males, 16 females; mean age 60 years) with angiographically documented CAD (=/>50% stenosis). The patients were divided into three groups according to the number of vessels affected; thus, 18 had single-vessel, 16 had two-vessel, and 52 had multiple-vessel disease. The severity of coronary lesions was assessed using the modified Gensini score. Serum adiponectin levels were measured in the CAD group and in a control group of 33 subjects (16 males, 17 females; mean age 54.8 years) who were found to have normal coronary arteries on angiography. The mean age, the number of male patients, and the number of smokers were significantly higher in the CAD group (p=0.01). Patients with CAD exhibited significantly lower serum levels of adiponectin compared to the c...
Implications of plasma concentrations of adiponectin in patients with coronary artery disease
Heart (British Cardiac Society), 2004
To investigate whether concentrations of plasma adiponectin constitute a significant coronary risk factor, with particular focus on the relation between plasma concentrations of adiponectin and the development of acute coronary syndrome (ACS). Plasma concentrations of adiponectin were measured in 123 patients with coronary artery disease (CAD) and in 17 control participants. Patients were divided into three groups according to condition type: acute myocardial infarction (AMI) group (n = 59), unstable angina pectoris (UAP) group (n = 28), and stable angina pectoris (SAP) group (n = 36). Plasma concentrations of adiponectin correlated negatively with body mass index (r = -0.18, p < 0.05), serum triglyceride (r = -0.25, p < 0.01), and fasting glucose concentrations (r = -0.21, p < 0.05), but correlated positively with age (r = 0.26, p < 0.01), high density lipoprotein cholesterol concentrations (r = 0.35, p < 0.01), and low density lipoprotein particle size (r = 0.37, p ...
Coronary Atherosclerosis : Adiponectin and Leptin as Predictors of Disease Severity
Jordan Journal of Biological Sciences, 2014
Adipose tissue is known to produce and release numerous bioactive substances, known as adipokines (such as leptin and adiponectin), which have been found to be involved in various physiological processes, including the regulation of arterial tone and they are related to cardiovascular risk factors. The objective of the present study was to determine the relationship between the levels of serum leptin and adiponectin and the degree of coronary heart disease, also, to compare the sensitivity and specificity of serum circulating levels of the these two biomarkers in CAD diagnosis. Forty nine patients with established coronary artery disease (CAD) defined as old myocardial infarction and angina pectoris classified as CAD group. The control group included twenty normal healthy subjects. All patients and controls were subjected to complete clinical history taking, clinical examination including 12 lead electrocardiograms (ECG), diagnostic coronary angiography (CA) and the colorimetric measurement of serum levels of triacylglycerols (TGs), total cholesterol (total-C), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), also, ELISA for measurement of leptin and adiponectin. The predictors of coronary atherosclerosis severity include higher LDL-C, low serum adiponectin level, higher leptin level and previous myocardial infarction. Serum levels of leptin, LDL-C and total-C showed highly significant (p< 0.0001) increase, while, adiponectin levels showed highly significant (p< 0.0001) decrease in the group of patients when compared to the levels of the control group. The levels of HDL-C in the group of patients were significantly (p< 0.05) lower than in the control group. There was no significant difference between the levels of TGs in the patients versus the controls. The levels of leptin showed negatively significant correlation with the levels of adiponectin (r=0.76, p<0.001), it was positively significant with the levels of LDL-C (r=0.302, p=0.035), while, there was no significant correlation between the levels of leptin and HDL-C and the levels of adiponectin and HDL-C, there was a weak but significant correlation between the levels of serum adiponectin and LDL-C (r=0.2, p=0.001). The overall positive rates obtained from Receiver Operating Characteristic (ROC) curve for evolution of sensitivity and specificity of the different biomarkers is obtained. The sensitivity was 100% for both leptin and adiponectin. ROC curve results revealed that the specificity for leptin and adiponectin were 100% and 90%, respectively. The results obtained in the present study indicate that serum leptin and adiponectin might play an important pathogenic role not only in the occurrence but also in the severity of CAD. The circulating level of leptin provides highly specific biomarker for CAD more than adiponectin.
Adiponectin and Mortality in Patients Undergoing Coronary Angiography
The Journal of Clinical Endocrinology & Metabolism, 2006
Context: The adipokine adiponectin has been suggested to protect from coronary artery disease (CAD). However, studies addressing the association between adiponectin and mortality are sparse. Objective: To elucidate the relationship between adiponectin and mortality. Design, Setting and Participants: Adiponectin was determined in 2473 persons with and 673 persons without angiographic CAD. During a mean follow-up period of 5.45 years, 427 persons with CAD and 55 persons without CAD died. Main Outcome Measure: Hazard ratios for mortality according to adiponectin levels. Results: Adiponectin was positively related to female gender, age, LDL cholesterol, HDL cholesterol, homocysteine, and N-terminal pro-B-type natriuretic peptide. It was inversely related to glomerular filtration rate, body mass index and triglycerides and was low in diabetes mellitus and CAD. An increase of one standard deviation in adiponectin was associated with unadjusted and fully adjusted hazard ratios for death from any cause of 1.31 (95% confidence interval [CI] 1.20-1.42) and 1.22 (95% CI 1.12-1.34), and for death from cardiovascular causes of 1.32 (95% CI 1.19-1.45) and 1.23 (95% CI 1.11-1.37), respectively. In angiographic CAD, stable CAD and unstable CAD, the predictive value of adiponectin was similar to that in the entire cohort, but it did not attain statistical significance in persons without angiographic CAD. Adiponectin was also positively related to the risk of death from noncardiovascular causes. Conclusions: Despite the common view about adiponectin as a protective molecule in cardiovascular disease high adiponectin independently predicts all-cause, cardiovascular and non-cardiovascular mortality in individuals with CAD.