Classic Kaposi sarcoma with sarcoid-like granulomas: A case report and literature review (original) (raw)
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An unusual case of pyogenic granuloma-like Kaposi sarcoma
2021
Kaposi sarcoma (KS) is not typically included in the differential diagnosis of lesions with clinical characteristics of pyogenic granuloma. However, cases of pyogenic granuloma-like Kaposi sarcoma have been reported in the literature. This variant is extremely rare and possesses clinical and histological findings consistent with both conditions. We report an elderly, immunocompetent man with pyogenic granuloma-like Kaposi sarcoma, which was clinically consistent with a pyogenic granuloma and possessed histological findings consistent with Kaposi sarcoma and pyogenic granuloma.
2017
Kaposi’s sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstitial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature.
Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma
Diagnostic pathology, 2012
In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized. A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated. Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed. Our findings suggest that changes in vascular resistance occurring during tumor pro...
A Case of Non-cutaneous Kaposi Sarcoma
Cureus
Kaposi sarcoma is a malignancy common in patients with acquired immune deficiency syndrome (AIDS). It is a proliferative soft-tissue tumor commonly manifesting as pigmented papules and nodules on the skin. Lesions can also appear on the mucosal lining of the oropharynx and other parts of the body such as the lymph nodes. Head and neck involvement in Kaposi sarcoma is not unusual; however, laryngeal involvement is not commonly seen. We report the case of a 31-year-old gentleman, a former smoker with AIDS, who developed a mass in the throat with progressive hoarseness of voice without stridor. An elective tracheostomy was done to protect his airway before performing a direct laryngoscopy with biopsy. Histopathology examination showed neoplastic spindle cells positive for CD31, erythroblast transformation specific-related gene, and human herpesvirus 8, consistent with Kaposi sarcoma. The diagnosis of laryngeal Kaposi sarcoma in immunodeficient patients requires a high index of suspicion, especially when it occurs without classical dermatological manifestation, an interesting feature in this report.
Classic Kaposi's sarcoma: a case report
Acta dermatovenerologica Croatica : ADC, 2005
A 60-year-old male from the Mediterranean area presented with edematous right leg and livid nodules and macules on the skin of upper and lower extremities. Biopsy specimen obtained from the right upper leg showed a pathohistologic finding indicative of Kaposi's sarcoma. Polymerase chain reaction testing revealed HHV-8 in the skin lesion. Serology for HIV was negative. Additional examinations did not reveal dissemination of the disease. Negative HIV serology, normal laboratory findings and absence of immunosuppressant therapy in the patient's history confirmed the diagnosis of the classic form of Kaposi's sarcoma.
Classic Kaposi Sarcoma from North-East India: A case report
IP Indian Journal of Clinical and Experimental Dermatology, 2020
Kaposi sarcoma (KS) is a low-grade vascular neoplasm caused by proliferation of lymphatic endothelium associated with human herpes-8 (HHV-8) infection. An 81-year-old male presented with 1-year history of multiple brownish papular lesions on lower limbs. He gave no history of high risk behaviour or treatment with immunosuppressants. Cutaneous examination revealed bluish-black discrete papules, small nodules and non-pitting edema on lower limbs, and large ulcerative plaques on left foot. Mucous membranes, lymph nodes and systemic examination were normal. Histopathological examination of the papular lesions showed spindle cell proliferation and vascular slits with extravasated red blood cells. Human immunodeficiency virus (HIV) serology was negative. However, total lymphocyte and absolute CD4+ T lymphocytes counts were reduced. We report this case of Classic Kaposi sarcoma (CKS) because of it's rarity in India as well as being the first report from Northeast India, indicating wide ethnic and geographical distribution of this condition.
Segmental Kaposi Sarcoma in an Immunocompromised Patient
2022
Kaposi sarcoma (KS) is a vascular tumor that classically presents as multiple violaceous lesions on the extremities in a widespread manner. A 60-year-old male with a history of immunosuppression in the setting of bilateral lung transplant presented with numerous violaceous papulonodules and patches localized on the left flank, with a biopsy confirming the diagnosis of KS. We present a rare case of KS presenting in a segmental distribution and review the available literature with a discussion of the possible mechanisms behind segmental and dermatomal KS.