Activation of sickle red blood cell adhesion via integrin-associated protein/CD47–induced signal transduction (original) (raw)

Activation of sickle red blood cell (RBC) adhesion is mediated through integrin-associated protein (IAP) signaling pathways, which are influenced by shear stress conditions. This study identifies the sickle RBCs as active participants in signal transduction affecting their adhesion characteristics under fluid dynamics resembling vasculature. The findings establish a new paradigm for understanding the mechanisms regulating sickle RBC adhesion, highlighting the synergistic effects of IAP stimulation and shear stress in promoting tyrosine phosphorylation, which is crucial for adhesion properties.