Cytoplasmic Ca2+ oscillations in pancreatic ß-cells (original) (raw)

This report reviews the significant advances in understanding cytoplasmic Ca2+ oscillations in pancreatic ß-cells, highlighting their intrinsic role in mediating insulin secretion. It discusses the use of innovative fluorescent indicators for measuring Ca2+ levels in isolated ß-cells, emphasizing methodological improvements and the dynamic nature of Ca2+ concentration changes. Further, it explores how these oscillations constitute a fundamental mechanism of insulin release, suggesting potential implications for diabetes treatment.