Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal (original) (raw)
Related papers
Assessing Profile and Treatment Outcome in Patients of Ocular Surface Squamous Neoplasia (OSSN)
Nepalese Journal of Ophthalmology
Purpose: This study has attempted to assess the profile and treatment outcome of patients with OSSN and report the recurrence rate following treatment of primary OSSN. Materials and Methods: This was a retrospective, non-comparative hospital based observational study. The case files of OSSN patients from Jan 2010 to Dec 2017were assessed. The study site was Himalaya Eye Hospital, Gharipatan, Pokhara. This hospital is the only eye hospital in province 4, Nepal. All the files of suspicious cases of conjunctival mass or OSSN were reviewed. Data regarding demographic characteristics, vision acuity, involved eye, clinical features, conjunctival lesion type, duration of symptoms, preoperative clinical diagnosis, history, other eye disease, associated systemic diseases, occupation as well as treatment modalities of the patients and its outcome were taken. Results: Out of 40 cases, females were 21(52.5%) vesus 19(47.5%) male. Amongthem, 19 patients had keratinized stratified squamous epithe...
Ocular surface squamous neoplasia in Northern Thailand: a 16-year review
BMC Ophthalmology, 2022
Purpose To evaluate clinical characteristics, treatments, and outcomes in patients with ocular surface squamous neoplasia (OSSN) at a tertiary center in Northern Thailand. Methods Patients diagnosed with either corneal-conjunctival intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC) from May 2000 to December 2015, were recruited. The patients’ demographics, symptoms, clinical characteristics, cytopathology, treatments, and outcomes were reviewed. Results Overall 171 eyes from 168 patients, 92 eyes were CIN and 79 eyes were SCC. Males were affected in 65.5%. The mean age was 58.8 ± 16.8 (29–99) years. In most cases (60.3%), the tumors were located at the limbus. The most common clinical characteristic was papilliform appearance (46.2%). Human immunodeficiency virus (HIV) infection was found in 37 (22.0%) patients with a mean age of 40.5 ± 7.7 years. The treatments and outcomes were evaluated in 136 eyes whose main initial treatment was wide excision with adjunctive cryot...
2021
Background: Ocular surface squamous neoplasia is a heterogenous group of proliferative squamous lesions on the ocular surface with varying biologic behaviours. This study aims to report the clinical profile and pathologic characteristics of cases of OSSN seen at a tertiary referral centre in North West NigeriaMethods: A retrospective review of all cases of OSSN diagnosed over a 10-year period was doneResults: OSSN accounted for 68 out of 91 ocular surface lesions affecting twice as many males as females and a peak incidence in the 30-39 years age group. They frequently presented as higher grade and higher stage lesions with invasive squamous cell carcinoma being the most frequently diagnosed OSSN. They also frequently show association with HIV infection and a relatively long duration of symptoms before presentationConclusion: OSSN occur in a relatively young age group in our environment. Certain clinical and epidemiological features appear to [predict the occurrence of higher grade ...
Clinicopathological review of ocular surface squamous neoplasia in Malawi
British Journal of Ophthalmology, 2013
Background Ocular surface squamous neoplasia (OSSN) is the most common cause of malignancy of the conjunctiva. Variable clinical presentation means that invasive malignant OSSN is often difficult to discriminate from other similarly presenting differential diagnoses which can be managed more conservatively. Aims Identification of clinical factors associated with a histopathological diagnosis of conjunctival squamous cell carcinoma (SCC). Methods Prospective consecutive case series of suspected OSSN cases presenting at two hospitals in Central Malawi over a 1 year period. A pro forma was completed assessing preidentified clinical variables. Suspected lesions underwent excisional biopsy followed by histopathological investigation. Results Fifty-eight patients were recruited. Mean age was 35.8 (range 22-62). 51 cases of histopathologically confirmed OSSN were found. 30 (50%) patients were confirmed HIV seropositive which rose to 86.67% in invasive SCC. Larger size of tumour (p=0.008), male gender (p=0.025) and HIV seropositivity (p=0.010) were associated with invasive SCC pathology. Conclusions A clinicopathological study of OSSN has not previously been performed in Malawi. The association of HIV with SCC corresponds to previous reports from sub-Saharan Africa. A new finding in our study is a relationship between larger tumour size and invasive lesions confirmed by histopathology. When integrated into a clinical decision-making model, tumour area provides a simple clinical measure for ophthalmic practitioners to use in order to differentiate higher risk OSSN from more benign pathology. The higher risk lesions can subsequently be treated with greater surgical care and undergo closer follow-up.
Clinical Profile of Ocular Surface Squamous Neoplasia A Retrospective Case series
IOSR Journal of Dental and Medical Sciences, 2014
This is a retrospective case series of 24 patients who underwent surgical excision for histopathologically proven cases of ocular surface squamous neoplasia (OSSN) at a tertiary care center over a period of two years. The commonest age group involved was 50-60 years (83.3%).Males and females were affected in equal proportion. All patients presented with a growth in the conjunctiva. Impression cytology whenever available was correlated with histopathology(100%).Systemic predisposing factors included xeroderma pigmentosa in one patient(4.16%) and AIDS in two patients(8.33%).Recurrence was found in two patients(8.33%),of which one was managed successfully with topical mitomycin and the other with resurgery.In OSSN,early and prompt surgical intervention is frequently curative.
Epidemiology of Ocular Surface Squamous Neoplasia in an Ophthalmology Center in Mexico City
Investigative Ophthalmology & Visual Science, 2016
objectives To describe the epidemiology and an aetiological model of ocular surface squamous neoplasia (OSSN) in Africa. methods Systematic and non-systematic review methods were used. Incidence was obtained from the International Agency for Research on Cancer. We searched PubMed, EMBASE, Web of Science and the reference lists of articles retrieved. Meta-analyses were conducted using a fixed-effects model for HIV and cigarette smoking and random effects for human papilloma virus (HPV). results The incidence of OSSN is highest in the Southern Hemisphere (16°South), with the highest age-standardised rate (ASR) reported from Zimbabwe (3.4 and 3.0 cases/year/100 000 population for males and females, respectively). The mean ASR worldwide is 0.18 and 0.08 cases/year/100 000 among males and females, respectively. The risk increases with exposure to direct daylight (2-4 h,
Vision
Ocular surface squamous neoplasia (OSSN) has a high incidence in the southern hemisphere. This prospective study evaluated the incidence of OSSN in the Waikato region of New Zealand. All patients presenting with pterygium or conjunctival lesions in the Waikato region in 2020 were included. All surgeons in the region were asked to send all conjunctival and corneal specimens excised for histopathologic examination. The primary outcome measure was the incidence of OSSN. Eighty-eight percent of all excised specimens were sent for histopathologic examination. Of the 185 excised lesions sent for histopathological assessment, 18 (10%) were reported as OSSN. Patients were on average 69.4 years of age (standard deviation, SD = 6.9), predominantly male (78%), and of New Zealand-European ethnicity (89%). The OSSN annual incidence was 3.67/100,000/year. Histology grades included conjunctival intraepithelial neoplasia (CIN)-I (25%), CIN-II (25%), CIN-III (12.5%), carcinoma in situ (25%), and inv...
Ocular Surface Squamous Neoplasia Impression Cytology V/S Histopathology
2014
Ocular Surface Squamous Neoplasia (OSSN) is spectrum of conjunctival and corneal epithelial neoplasia manifesting as dysplasia, carcinoma-in-situ (CIS) and squamous cell carcinoma (SCC). OSSN has a wide geographical variation, ranging from 0.13 to 1.9 per 100,000 population. Males are affected more often than females. The average age is usually sixth and seventh decade. The abnormal maturation of neoplastic cells is reflected in the morphology of the surface cells and their study forms the underlying principle of cytology. In impression cytology, either cellulose acetate paper or Biopore membrane is used for sampling. The study was conducted between June 2008 and May 2013.The study included 170 eyes of 168 patients. Biopsies from 168 patients found to have histologically proven OSSN are included in the study. On cytomorphology 130/170 specimens (76.4%) correlated with histopathology. Histological spectrum showed well differentiated SCC 34(33.3%) moderately differentiated SCC 53(51.9...