Preparation and Evaluation of Glycine max, Trigonella foenum, Glycyrrhiza glabra and Aloe barbadensis Extracts Vaginal Cream (original) (raw)
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Journal of Traditional and Complementary Medicine, 2019
Background: Vaginal atrophy is one of the most common menopausal complications affecting women's quality of life. The present study aimed to investigate the impact of Glycyrrhiza glabra (licorice) vaginal cream on vaginal signs and symptoms of vaginal atrophy in postmenopausal women. Methods: This randomized controlled trial was conducted on 70 menopausal women, referring to health centers of Izeh city, located in the south west of Iran, from May to November 2017. The participants with vaginal atrophy were randomly assigned into two groups of 35. One of the groups received licorice 2% vaginal cream while the other was given placebo over a period of 8 weeks. Data were analyzed using SPSS software at the significance level of 0.05. Results: The results indicated that at the baseline, none of the subjects (0%) in either groups had a vaginal cells maturation Index within 65e100 in MVI category. However, after 8 weeks of therapy, it improved significantly to 82.9% in Licorice group and 11.4% in the placebo group (p < 0.001). Also, the vaginal mucus cells changed from the baseline cells to intermediate and superficial cells within and between the two groups after the treatment (p < 0.001). Finally, the pH level significantly decreased in licorice group over time (p < 0.001). Conclusion: Therapeutic use of licorice vaginal cream can improve the signs and symptoms of vaginal atrophy in postmenopausal women. Accordingly, use of licorice as a natural vaginal cream in vaginal atrophy can be suggested.
Traditional and Integrative Medicine
Vaginal atrophy is one of the most common complaints in postmenopausal women. Symptoms of vaginal atrophy include dryness, itching, bleeding, and dyspareunia. According to Traditional Persian Medicine (TPM), the using of moisturizing plants can treat dry mucous membranes. TPM suggests the use of marshmallow (Alcea angulata) to moisturize dry mucus with its mucilage. The aim of this study was to evaluate the effect of Alcea on the treatment of vaginal atrophy. This double-blind, clinical trial was conducted on 60 postmenopausal women with vaginal atrophy (40 – 65 years of age). The patients were randomly assigned into two groups of treatment and control (n = 30). The treatment group received Alcea vaginal suppository 5% (125 mg), and the control group received placebo. Both groups used suppositories every night for two weeks and every other night for six weeks. Vaginal Maturation Value (VMV), symptoms of vaginal atrophy, and pH were compared before and after the intervention. Data we...
Treatment of Vaginal Atrophy with Vaginal Estrogen Cream in Menopausal Indian Women
Oman medical journal, 2017
To measure the effect of vaginal estrogen cream in the treatment of vaginal atrophy in menopausal Indian women. A total of 50 menopausal women aged between 40 and 80 years old with symptoms of vaginal atrophy were selected and treated with 0.5 g vaginal estrogen cream, twice weekly for 12 weeks. The women were followed-up monthly where symptom score, Genital Health Clinical Evaluation (GHCE) score, vaginal pH, and vaginal maturation index (VMI) were assessed and compared to baseline data. Any adverse events were recorded. There was a significant improvement (p < 0.010) in complaints such as vaginal dryness, itching, burning, and dyspareunia at the end of the study period. The clinical improvement of these patients was reflected in a decrease in GHCE score on every visit. Vaginal pH and VMI score also showed statistically significant improvements (p < 0.010). No side effects with the drugs used were recorded during the study period. Vaginal estrogen cream causes symptomatic rel...
Preparation and evaluation of herbal cosmetic cream
Pharmacologyonline
The present study was to prepare and evaluate the herbal cosmetic cream comprising extracts of Glycyrrhiza glabra, Cucumis sativus and almond oil. Different types of formulations oil in water (O/W) herbal creams namely F1 to F7 were formulated from the ethanol extract of Glycyrrhiza glabra (rhizomes), Cucumis sativus (fruits) and almond oil in varied concentrations. The evaluation of all formulations (F1 to F7) was done on different parametrs like pH, viscosity, spreadability, rheological study, and stability along with irritancy test were examined. Formulations F5 and F6 showed good spreadability, good consistency, homogeneity, appearance, pH, ease of removal, spreadibilty and no evidence of phase separation. The formulation F5 and F6 shows no redness, edema, inflammation and irritation during irritancy studies. These formulations are safe to use for skin. These studies suggest that composition of extracts and base of cream of F5 and F6 are more stable and also it may produce syner...
Pharmaceutical assessment of body lotion: A herbal formulation and its potential benefits
International Journal of Pharmacy and Pharmaceutical Science, 2023
Background: Protective layers of skin cover the body. Plant-based herbal body lotion soothes and moisturises. Treatments commonly include succulent aloe vera, which heals, reduces pain, and moisturises. For hundreds of years, it has healed skin burns and injuries. Aim: This study aims on the pharmaceutical assessment of Aloe-vera by formulating an herbal Body lotion. Material and Method: Aloe-vera, Honey, Glycerin, Rose Water and Triethanolamine were taken for the formulation of herbal body lotion. Evaluation parameters were also performed to evaluate the formulation and to make sure that the subjected formulation is not harmful for the human mankind. Result: The aloe vera body lotion was formulated by using various type of ingredients such as Aloevera, glycerin, rose water, honey and Triethanolamine. Aloe-vera contain antimicrobial and hydrating properties protect skin against microbial degradation and moisture to skin. Conclusion: herbal body lotion is prepared for tropical administration. Aloe vera is used in lotion to provide synergistic effect as well as moisturizing effect on skin. Herbal remedies are experiencing a surge in popularity worldwide. The utilization of aloe vera, honey, Coconut oil, Lemon Oil and glycerin in the formulation of an herbal lotion is an exemplary notion.
Medicine and Pharmacy Reports, 2017
Background and aims. The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream.Methods. The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1 (F1) was prepared using glyceryl stearate and Ceteareth-25® as emulsifiers and Formulation 2 (F2) using glyceryl stearate and potassium cetyl phosphate, all other ingredients remaining the same. The physical characterization of the creams was performed and the following parameters were analyzed: viscosity, oil droplet size, polydispersity index; also, texture analysis was performed. The anti-aging effect of the F2 was evaluated by assessing the cutaneous density before and after cream application using DUB-cutis® scanner.Results. The mean diameter of oil drops was 10.26±4.72 mm (F1) and 22.72±7.93 mm (F2) and the polydispersity inde...
Phytochemical Properties of Skin Care Cream Containing Essential Oil of Galangal
Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018), 2018
A research has been conducted on development and physicochemical characterization of skin care cream containing essential oils of galangal. The skin care cream containing essential oils of galangal developed consists of a red galangal cream that utilizes the essential oil ingredients extracted from red galangal rhizomes and white galangal cream that utilizes the essential oil ingredients extracted from the white galangal rhizomes. Cream is made by homogeneously mixing each of the red galangal essential oils and each of the white galangal essential oils with basic cream in concentration variations of 0.25%, 0.50%, 0.75%, 1.00%, and 1.50%. Each galangal cream then tested its physicochemical character and the acceptance level of its panellists. The results of this study are two types of galangal cream products, namely red galangal cream and white galangal cream. The galangal cream is a mixture that looks homogeneous, with white to slightly brownish colour, and has a typical odor of galangal. Each type of creams having a density range of 0.94 g/cm 3 to 0.96 g/cm 3 is a physically viscous mixture, with viscosity ranging from 37,007 cps to 37,413 cps for red galangal creams and 37,055 cps to 37,453 cps for white galangal creams. Spreading capacity of galangal creams is about 40.50 cm 2 to 44.50 cm 2 , wider 0.50 cm 2 to 4.50 cm 2 compared to basic cream which have spreading capacity 40.00 cm 2. The results of the hedonic sensory test show that 75%-80% or more panellists are quite acceptable up to strongly accept the physicochemical character of each red galangal creams and white galangal creams.
Formulation and Evaluation of Multipurpose Herbal Cream
Herbal cosmetics are the preparations used to enhance the human appearance. The aim of the present research was to formulate the herbal Cream for the purpose of Moistening, Nourishing, lightening & Treatment of various diseases of the skin. Different crude drugs; Aloe barbadensis (Aloe Vera leaves), Ocimum Sanctum (Tulsi-leaves), Azadirachta Indica (Neem-leaves), Curcuma longa (Turmeric-rhizomes), Cedro Oil(Lemon Peel), Myristica fragrans(Nutmeg seeds), Olium rosae(Rose Oil), Orange Oil, Prunus dulcis (Almond oil) were taken. Accelerated stability testing of two final sample has been conducted in the environmental chamber with temperature 25 ± 1 0 C and humidity 60 ± 10% RH. All the products were found to be stable with no sign of phase separation and no change in the color. The patch test for sensitivity testing has also been done and no evidence of skin irritation and allergic signs. This work mainly focuses on the assessment of the microbial quality of Formulated cosmetic preparations. To the surprise, both formulations was found to comply with the microbial limit tests as per the international specifications. Thus herbal cosmetics formulation is safe to use was proved and it can be used as the provision of a barrier to protect skin.
Asian Journal of Pharmaceutical and Clinical Research, 2018
Objective: The present study assessed the antioxidant activity, phytochemical content, and anti-Candida albicans property of ethanolic extract of Glycyrrhiza glabra L. (licorice). In addition, suppository formula (SF) was developed with licorice extract (LE), and the stability of SF was evaluated.Methods: The total phenolic and flavonoid content was measured by colorimetric methods. 2, 2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), inhibition of lipid peroxidation (LPO), nitric oxide (NO), and superoxide (SO) radical scavenging assays were performed to evaluate antioxidant property. Antimicrobial activity was determined by plating method. The active principle was determined by high-performance liquid chromatography method.Results: The licorice sample was extracted with 95% ethanol, and 26.91±1.35% of yield was observed. The LE contains phenolic acids (167.70±3.18 mg gallic acid equivalent/g extract), flavonoids (162.53±9.95 mg qu...