Role of intra-operative sentinel lymph node biopsy in oral cavity and oropharynx squamous cell carcinoma: preliminary data (original) (raw)
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The Value of Sentinel Lymph Node Biopsy in Oral Cavity Cancers
Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology, 2015
The aim of this study was to establish the effectiveness of sentinel lymph node biopsy in the detection of metastasis in N0 necks of T1-T2 early-stage oral cavity cancers. Materials and Methods: Twenty neck dissections were performed in 18 patients diagnosed with T1 and T2 oral cavity cancer, with an indication for elective neck dissection between November 2007 and January 2011. The male to female ratio was 12:8, with a mean age of 54.5 years (range 28-76). Eight of the dissections were performed for lower lip cancer, 7 for tongue cancer, and 5 for floor of the mouth cancer. Sentinel lymph node biopsy was used to detect metastatic lymph nodes. Tc99m radionuclide injection was administered to the periphery of the tumor 24 h before the operation, and a lymphoscintigraphy image was obtained 30 min after the injection. Sentinel lymph nodes were localized and excised on the day of surgery using static lymphoscintig-raphy images and a gamma probe. Sentinel lymph nodes were sent for a frozen section examination, and either a selective or a comprehensive neck dissection was performed for each neck according to the results. Results: After the final histopathological examination of the specimens, the negative predictive value, the positive predictive value, the accuracy of the sentinel lymph node biopsy, and frozen section accuracy were found to be 100%. Conclusion: Sentinel lymph node biopsy was found to be an efficient method in the pathological staging and management of the N0 neck in early T-stage oral cavity cancers.
Sentinel Lymph Node- a Captain in the Management of Oral Squamous Cell Carcinoma
Journal of Evolution of Medical and Dental Sciences, 2018
BACKGROUND Squamous cell carcinoma represents about 2-3% of all malignant neoplasms & 47% of those arising in Head & Neck area. Incidence of Oral Squamous Cell Carcinoma is increasing especially in young people. The status of lymph node involvement holds prime importance in the prognosis and therapy of Oral Squamous Cell Carcinoma (OSCC). The risk of neck metastasis depends on the site, size, grading and depth of infiltration of tumour. Neck dissection is the only surgical option for pathologic staging of neck in patients with OSCC. However, often a minimally invasive sentinel lymph node biopsy may be adequate. Sentinel Node biopsy is a novel useful technique alternative to neck dissection in the management of OSCC. Sentinel lymph node offers accurate staging with minimal morbidity. Selective excision, meticulous histopathological examination of sentinel lymph nodes play a very important role in preserving the surgical approach to a N0 carcinoma. Aim of this study was to evaluate the role of sentinel lymph node in staging and treatment of Oral Squamous Cell Carcinoma in a Tertiary cancer care center.
Sentinel lymph node biopsy for oral cancer
Journal of Visualized Surgery
We have used sentinel lymph node biopsy (SLNB) for oral cancer patients since 2001. Our lymphoscintigraphic, surgical as well as the histopathological examination technique has developed and been refined over the last 15 years. We use three dimensional SPECT-CT images for high accuracy identification of the sentinel lymph nodes, a simple one incision surgical approach and frozen sectioning for fast histopathological evaluation of the lymph nodes. These refinements have enabled us to perform the sentinel lymph node procedure and neck dissection in the correct patients in a same day procedure in the majority of patients.
Bratislavské lekárske listy, 2010
The aims of the study were to assess our feasibility and accuracy of sentinel lymph node radiolocalization in patients with squamous cell carcinoma of the oral cavity and oropharynx, and to determine whether the pathology of the sentinel node reflected regional disease. Patients preoperatively underwent lymphoscintigraphy after peritumoral injection of a 99m Tc labeled radiocolloid. After perioperative gamma probe radiolocalization of the sentinel lymph nodes, elective neck dissection was performed. The histopathological examination of the sentinel nodes and other nodes of neck dissection specimen were compared. Detection of sentinel lymph nodes by lymphoscintigraphy was feasible in all 12 patients. Also localization with a handheld gamma probe was successful in all patients. Forty sentinel nodes and 276 non-sentinel nodes were histopathologically examined. Occult metastases were confirmed in 7 sentinel nodes (4 patients). There was no false negative sentinel lymph node in our serie...
Sentinel Node Biopsy in Squamous Cell Carcinoma of the Oral Cavity
2007
Head and Neck Squamous Cell Carcinoma (SCC) spreads via lymphatics to the regional draining lymph nodes in the neck. Since the presence of lymph node metastases is the most important prognostic factor in Head and Neck (H&N) cancer, decreasing survival by 50%, reliable staging of the neck in this disease is imperative to determine further management. [14] Data from Literature show an incidence of occult metastases in oral cavity tumours ranging from 12% to 50% (mean 33%). Traditional imaging techniques (UlS, CT, MRI) are not able to obtain a detailed staging of N0 neck, having a specificity of 75% to 92% [14]. So, for most Authors [7, 23] the gold standard in these cases is to treat the patients with elective neck dissection and routinelly pathological examination of the surgical specimen. This policy means that up to 60-70 % of patients with N0 neck have unnecessary operations, with
The role of sentinel node biopsy in oral squamous cell carcinoma
Plastic and Aesthetic Research, 2016
Aim: The purpose of this study was to conduct a systematic review of the published literature to assess the state of the art of this procedure. Sentinel node biopsy (SNB) in oral squamous cell cancer (OSCC) is a novel and proven useful technique alternative to the neck dissection (ND) in the management of OSCC. Methods: The authors searched PubMed for literature in English published for the last five years, addressing this topic. Prospective studies articles were selected with at least thirty patients studied. Results: Of 235 studies found, 14 studies met the exclusion and inclusion criteria for this review. The studies selected focused on the role of the SNB in the OSCC, advantages compared to ND and its limitations, testing different solutions and innovations that could implement the conventional procedure. Meta-analysis studies and review articles were also selected in order to perform the introduction and support the discussion. Based upon these findings authors have tried to establish the state of the art of the SNB and authors have highlighted recent advances that improve the sentinel lymphatic node biopsy technique in the future. Conclusion: SNB is an excellent staging method in OSCC and an interesting alternative to ND. The authors show the most appropriate procedures recommended in the bibliography revised in a trend to depict the actual state of the art.