Further evidence for a parathyroid hormone-related protein in fetal parathyroid glands of sheep (original) (raw)

Quarterly journal of experimental physiology (Cambridge, England), 1988

Abstract

Extracts of ovine fetal parathyroid glands contained a substance in addition to parathyroid hormone (PTH) which could not be neutralized by antiserum against PTH in a cytochemical bioassay. This substance reacted similarly to human parathyroid hormone-related protein, the humoral hypercalcaemic factor associated with malignancy in man. The ovine fetal PTHrP may be responsible for maintaining the fetus hypercalcaemic relative to the mother.

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