Regulation of output of electrolytes in bile and pancreatic juice in sheep (original) (raw)

1972, Australian journal of biological sciences

Bile and pancreatic juice were collected from conscious, standing sheep with fistulae of the common bile duct, before and during infusions of secretin to the portal vein, and during infusion of acid to the duodenum. The output of volume and electrolytes, particularly bicarbonate, in bile and in pancreatic juice increased during infusion of secretin. However, the output of volume and of bicarbonate was three to five times higher in bile than in pancreatic juice. When acid was infused into the duodenum a similar result was obtained, and the increment in total bicarbonate output was similar to the amount of acid infused. Infusions of sodium taurocholate were associated with further increases in the output of volume, bile salts, chloride, sodium, potassium, and bicarbonate in bile, but there were no changes in the volume or composition of pancreatic juice. It is suggested that in normal sheep the entry of acid into the duodenum results in release of secretin, and that this stimulates the output of water, bicarbonate, and other electrolytes, particularly from the liver.