Plasma homocysteine levels in patients with Psoriasis (original) (raw)
Asian Journal of Medical Sciences
Background: Hyper homocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Aims and Objective: The aim of this study is to investigate homocysteine in psoriatic patients and its relationship with the severity of the disease. Materials and Methods: A case control study in 50 patients with chronic plaque psoriasis and 50 healthy controls was performed. Total plasma homocysteine level, and PASI index were assessed in every patient. Results: Patients with psoriasis had plasma homocysteine levels higher than controls. The severity of psoriasis assessed according to PASI directly correlate either with plasma homocysteine. Conclusion: A significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls. Our data directly correlate the high level of homocysteine with higher PASI scores.
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