P.73 Carnitine esters: markers of ‘carnitine insufficiency’in preterm and term neonates (original) (raw)
Recovery of samples spiked with 1 #g/I vitamin K 1 was 97% for normolipidaemic samples and 95% for hyperlipidaemic samples. Plasma vitamin K1 samples from fasting healthy volunteers with normal plasma cholesterol (<5.2~m01/I) and triglyceride (<2.3mmol/I) were compared with those with elevated plasma lipids. Results: (median, range in brackets) Cholesterol Triglyceride Vitamin K 1 (mmol/I) (mmol/I) (~Lg/I) Norrnolipidaemic (n = 17) 4.70 (2.70-5.20) 1.00 (0.60-1.70) 0.42 (0.23-0.87) Hyperlipidaernic (n = 26) 5.90 (5.30-7.60)* 1.95 (0.90-7.50)* 0.96 (0.38-6.98)* *P < 0.001. Comparison with normolipidaemic group, Mann-Whitney U-test. There was a significant correlation between triglyceride and vitamin K~ (r = 0.62; P < 0.001) but no correlation between cholesterol and vitamin K~ (r= 0.16; P> 0.05) using regression analysis. Conclusions: Plasma lipids must be considered in studies of assessment of vitamin K status using plasma concentration.
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