fMRI study of the motor system dynamics using the deconvolved evoked response of activated pixels (original) (raw)
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Neuroimage
We have performed a noninvasive bilateral optical imaging study of the hemodynamic evoked response to unilateral finger opposition task, finger tactile, and electrical median nerve stimulation in the human sensorimotor cortex. This optical study shows the hemoglobin-evoked response to voluntary and nonvoluntary stimuli. We performed measurements on 10 healthy volunteers using block paradigms for motor, sensory, and electrical stimulations of the right and left hands separately. We analyzed the spatial/temporal features and the amplitude of the optical signal induced by cerebral activation during these three paradigms. We consistently found an increase (decrease) in the cerebral concentration of oxy-hemoglobin (deoxy-hemoglobin) at the cortical side contralateral to the stimulated side. We observed an optical response to activation that was larger in size and amplitude during voluntary motor task compared to the other two stimulations. The ipsilateral response was consistently smaller than the contralateral response, and even reversed (i.e., a decrease in oxy-hemoglobin, and an increase in deoxy-hemoglobin) in the case of the electrical stimulation. We observed a systemic contribution to the optical signal from the increase in the heart rate increase during stimulation, and we made a first attempt to subtract it from the evoked hemoglobin signal. Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging.
Localization of brain electrical activity sources and hemodynamic activity foci during motor imagery
Human Physiology
The sources of brain activity that make the maximum contribution to EEG patterns corresponding to motor imagery have been studied. The accuracy of their classification determines the efficiency of brain-computer interface (BCI) for controlling external technical devices directly by brain signals, without the involvement of muscle activity. Brain activity sources are identified by independent component analysis. The independent components providing the maximum BCI classification accuracy are considered relevant for the motor imagery task. The two most relevant sources exhibit clearly marked event-related desynchronization and synchronization of the μ-rhythm during the imagery of contra- and ipsilateral hand movements. These sources were localized by solving the inverse EEG problem with due consideration for individual geometry of the brain and its covers, as determined by magnetic resonance imaging. Each of the sources was shown to be localized in the 3a area of the primary somatosen...
NeuroImage, 2000
Rapid-presentation event-related functional MRI (ER-fMRI) allows neuroimaging methods based on hemodynamics to employ behavioral task paradigms typical of cognitive settings. However, the sluggishness of the hemodynamic response and its variance provide constraints on how ER-fMRI can be applied. In a series of two studies, estimates of the hemodynamic response in or near the primary visual and motor cortices were compared across various paradigms and sampling procedures to determine the limits of ER-fMRI procedures and, more generally, to describe the behavior of the hemodynamic response. The temporal profile of the hemodynamic response was estimated across overlapping events by solving a set of linear equations within the general linear model. No assumptions about the shape were made in solving the equations. Following estimation of the temporal profile, the amplitude and timing were modeled using a ␥ function. Results indicated that (1) within a region, for a given subject, estimation of the hemodynamic response is extremely stable for both amplitude (r 2 ؍ 0.98) and time to peak (r 2 ؍ 0.95), from one series of measurements to the next, and slightly less stable for estimation of time to onset (r 2 ؍ 0.60). (2) As the trial presentation rate changed (from those spaced 20 s apart to temporally overlapping trials), the hemodynamic response amplitude showed a small, but significant, decrease. Trial onsets spaced (on average) 5 s apart showed a 17-25% reduction in amplitude compared to those spaced 20 s apart. Power analysis indicated that the increased number of trials at fast rates outweighs this decrease in amplitude if statistically reliable response detection is the goal. (3) Knowledge of the amplitude and timing of the hemodynamic response in one region failed to predict those properties in another region, even for within-subject comparisons. (4) Across subjects, the amplitude of the response showed no significant correlation with timing of the response, for either time-to-onset or time-to-peak estimates. (5) The within-region stability of the response was sufficient to allow offsets in the timing of the response to be detected that were under a second, placing event-related fMRI methods in a position to answer questions about the change in relative timing between regions.
Frontiers in Neuroscience
Transcranial magnetic stimulation-electroencephalogram (TMS-EEG) co-registration offers the opportunity to test reactivity of brain areas across distinct conditions through TMS-evoked potentials (TEPs). Several TEPs have been described, their functional meaning being largely unknown. In particular, short-latency potentials peaking at 5 (P5) and 8 (N8) ms after the TMS pulse have been recently described, but because of their large amplitude, the problem of whether their origin is cortical or not has been opened. To gain information about these components, we employed a protocol that modulates primary motor cortex excitability (MI): low frequency stimulation of premotor area (PMC). TMS was applied simultaneously with EEG recording from 70 electrodes. Amplitude of TEPs evoked by 200 single-pulses TMS delivered over MI at 110% of resting motor threshold (rMT) was measured before and after applying 900 TMS conditioning stimuli to left PMC with 1 Hz repetition rate. Single subject analyses showed reduction in TEPs amplitude after PMC conditioning in a sample of participants and increase in TEPs amplitude in two subjects. No effects were found on corticospinal excitability as recorded by motor-evoked potentials (MEPs). Furthermore, correlation analysis showed an inverse relation between the effects of the conditioning protocol on P5-N8 complex amplitude and MEPs amplitude. Because the effects of the used protocol have been ascribed to a cortical interaction between premotor area and MI, we suggest that despite the sign of P5-N8 amplitude modulation is not consistent across participant; this modulation could indicate, at least in part, their cortical origin. We conclude that with an accurate experimental procedure early latency components can be used to evaluate the reactivity of the stimulated cortex.
Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response
NeuroImage, 2004
While recent reports have advocated the use of magnetic resonance imaging (MRI) to detect the effects of neuronal currents associated with human brain activity, only preliminary experimental data have been presented so far to demonstrate the feasibility of the method. Furthermore, it has not been adequately demonstrated that (1) MRI can separate neuronal current (NC) effects from other effects such as blood oxygen level-dependent (BOLD) contrast; (2) MRI has adequate sensitivity to detect NCs in vivo. In this work, we introduce a method that can separate slow (e.g., BOLD) processes from potential rapid (e.g., NC) processes and apply this method to investigate whether MRI allows detection of an NC response to a visual stimulus. MRI studies (n = 8) at 3.0 T using a sensitive multichannel detector showed insignificant effects related to NCs (averaged t b 0.05), in the presence of a highly significant BOLD signal (t = 6.15 F 0.90). In contrast, magnetoencephalography (MEG) experiments performed under similar conditions on the same subjects showed highly significant electrical activity (t = 7.90 F 2.28). It is concluded that, under the conditions used in this study, the sensitivity of MRI to detect evoked responses through NCs is at least an order of magnitude below that of BOLD-based functional MRI (fMRI) or MEG and too low to be practically useful. Published by Elsevier Inc.
Trial-to-trial variability of cortical evoked responses: implications for the analysis of functio
2001
The time series of single trial cortical evoked potentials typically have a random appearance, and their trial-to-trial variability is commonly explained by a model in which random ongoing background noise activity is linearly combined with a stereotyped evoked response. In this paper, we demonstrate that more realistic models, incorporating amplitude and latency variability of the evoked response itself, can explain statistical properties of cortical potentials that have often been attributed to stimulus-related changes in functional connectivity or other intrinsic neural parameters.
Brain Electrical Activity Mapping (BEAM) imaging evoked responses
Conventional methods for interpreting cortical evoked potential data rely on the visual inspection of multichannel polygraphic recor dings. Presentation of the data in this form obscures the spatial relationships which exist among the data thereby complicating analysis and interpretation. A system has been developed, based on the work of Duffy et al. 1 , which uses computers to organize the spatio-temporal information of evoked potential data into the form of topographic brain electrical activity maps (BEAM). Using these methods, the data are represented on a color video screen as a temporal sequence of map images. Each map, repre:enting the electrical activity on the scalp at a single instant of time, is constructed by interpolating the potentials measured at sixteen electrode locations. Methods of measuring the signals and constructing the image sequences are discussed with emphasis on a newl y-developed interpolation process using linear filtering.