RECENT TRENDS IN MICROSPHERE DRUG DELIVERY SYSTEM AND ITS THERAPEUTIC APPLICATIONS (original) (raw)
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Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres used in the formulation of microsphere drug delivery system and its applications
MICROSPHERES AS A NOVEL DRUG DELIVERY SYSYTEM -A REVIEW
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs to the tumour. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.
MICROSPHERES: AS NEW DRUG DELIVERY SYSYTEM
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion.
-Microspheres as a novel drug delivery system-a review
International journal of pharmaceutical sciences review and research, 2022
Controlled drug delivery system can conquer the issues of conventional drug therapy and gives better therapeutic efficacy of a drug. The microspheres are one of the novel drug delivery system which can be given as an effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Microspheres are spherical free flowing powder having particle size less than 200µm, consisting of synthetic polymers and proteins which are biodegradable in nature. Microsphere improves bioavailability, reduces the side effects, improves stability, decreases dose frequency and targets the drug to specific site at predetermined rate. The different types of microspheres are bioadhesive, floating, radioactive, polymeric and biodegradable microspheres. In future microspheres will track down the focal spot in novel drug delivery conveyance, especially in diagnostics, genetic materials, targeted and effective drug delivery.
Microsphere A Novel Drug Delivery System – A Review
International Journal of Scientific Research in Science and Technology, 2023
The microspheres are also called as micro-particles. Microspheres are characteristically spherical & free flowing powders having particle size ranging from 1-1000μm consisting of proteins or synthetic polymers. Microsphere can be manufactured by various type of material such as glass, polymers, and ceramic microspheres Microspheres are used in drug delivery systems to overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug they are designed. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. At the target tissue the drug should deliver in an optimal amount in the right period of time with the minimum side effect & maximum therapeutic effect, to get the desired effect. The microspheres received much attention not only for the prolonged release or controlled drug delivery to improve bioavailability, stability and action at the specific site to predetermined rate but also for targeting of the anticancer drugs to the tumour. Microspheres are various types like Bioadhesive microspheres, Magnetic microspheres, Floating microspheres, radioactive microspheres, Polymeric microspheres, Biodegradable polymeric microspheres, Synthetic polymeric microspheres. The microsphere are spherical microparticles & are used where predictable & consistent particle surface area is important. The microspheres has the drug located centrally within the particle where it is encased within the unique polymeric membrane. This review focuses on types, materials used, drawbacks, advantage & disadvantage.
Microspheres: A Promising Drug Carrier
Journal of Drug Delivery and Therapeutics, 2016
In the current scenario of delivering therapeutic agents to the target site requires an efficient drug delivery carrier which can deliver the drug only on the site of action in a sustained and controlled manner. Among many such carriers, microspheres fulfill all the parameters for an potent drug carrier. Microspheres are defined as free flowing powders of spherical shape, consisting of proteins or synthetic polymers, which are either biodegradable or non-biodegradable in nature and ideally having a particle size ranging from 1-1000 μm. The main aim of such novel drug delivery system is to overcome the limitations of conventional dosage forms and providing more patient compliance, increase bioavailability and more specifically targeted delivery of drugs or other active agents. This review articles deals with the ideal characteristics, types, methods of preparation, their characteristics evaluation, in vitro-in vivo correlation and applications of microsphere as drug carrier. There are various methods available today for the preparation of microspheres with the goal of achieving reproducibility and consistency with good entrapment efficiency.
Microspheres: The Efficient Controlled Drug Delivery Carriers
Acta Scientific Pharmaceutical Sciences
Microspheres, free-flowing solid powders are generally made up of biodegradable and biocompatible polymers. Oral, parental, nasal, Ocular, transdermal, colonel, and other routes can be used to administer microspheres with particle sizes ranging from 0.1 to 200 micrometer. Microspheres play a totally vital position as particulate drug transport machine due to their small length and different green properties. Microspheres had been proved to be a appropriate bridge to scale the gap over to formulate an powerful dosage form, to simulate managed drug release. Numerous recent advancements in microspheres, such as mucoadhesive, hollow, magnetic and floating have contributed to overcoming the various challenges connected with their usage such as site specific targeting and enhanced release kinetics. Microspheres will play a key role in novel drug delivery in the future, thanks to a combination of new methodologies, particularly in sick cell sorting, genetic materials, and safe, targeted, and effective drug delivery. Oral modified release microspheres have always proven to be a more effective treatment option than single-unit dosage forms that are released immediately. Multi-particulates are commonly formed into microspheres and filled into hard gelatin capsules as the final dose form. Microspheres have attracted a lot of interest, not just for their long term. It can be used now not excellent for release but moreover for drug targeting. Microspheres will play an increasingly more crucial characteristic in future drug delivery, especially in ailment treatment, diagnosis, genetic material, and targeted effective drug delivery.
Microsphere: A Novel Drug Delivery System
International journal of pharmacy and technology, 2020
Microspheres are normally free flowing powders contains proteins or synthetic polymers which has biodegradable in nature and having a particle size but 200-500 μm. Number of techniques for the preparation of microspheres offers a spread of opportunities to regulate aspects of drug administration and enhance the therapeutic efficacy of a drug. A neat controlled drug delivery system can overcome a number of problems of conventional therapy and enhance therapeutic efficacy of the drug. There are various approaches in delivering therapeutic substance to the target site in sustained and controlled release fashion. These are prepared by methods like Single emulsion, Double emulsion, Polymerization, Phase separation coacervation, Emulsion solvent evaporation and solvent diffusion. Microspheres are having wide selection of applications due to controlled and sustained release.
Microsphere: a promising approach for drug delivery
Journal of Applied Pharmaceutical Research, 2019
The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 μm to 1000 μm (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API. It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day's microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
A Novel Drug Delivery System: Review on Microspheres
Journal of Drug Delivery and Therapeutics, 2021
Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the ri...