Melatonin and human mitochondrial diseases (original) (raw)

2017, Journal of Research in Medical Sciences

which are a group of complications caused by mitochondrial dysfunction. Mitochondrial diseases are also caused by mutations in the mitochondria affecting mitochondrial function. Mutations in mitochondria are also facilitated by high level of oxidative stress. [15] Melatonin has been shown to play a crucial role in regulation of mitochondrial homeostasis. Melatonin, in addition to being a powerful antioxidant, decreases nitric oxide (NO) generation in mitochondria and maintains bioenergetic functions of the cell. [16,17] The purpose of the current study was to identify melatonin production, metabolism, and clinical effects in diseases related to mitochondrial dysfunction including diabetes, cancer, and diseases related to brain function. Furthermore, the mechanisms through which melatonin can exert neuroprotection against neurodegenerative disorders related to mitochondrial dysfunctions are reviewed.