Correlation between Serum Uric Acid with Type 2 Diabetes Mellitus and its Complications (original) (raw)
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Relation between serum uric acid and diabetes type II
International Journal Of Community Medicine And Public Health
Incidence of diabetes mellitus type 2 has been increasing worldwide, making the disease of extreme importance. Several reports have suggested a possible association between serum levels of uric acid (SUA) and higher incidence of diabetes mellitus type 2. On a biological basis, uric acid can negatively affect insulin resistance in animals. This occurs due to the inhibition of nitric oxide which is crucial to achieve glucose uptake. In this study, we aim to: report on previous literature on relation between serum uric acid and diabetes type II in Saudi and prevalence of association between them. PubMed database and EBSCO Information Services were used for articles selection. All relevant articles to our review with the topics regarding the relation between serum uric acid and diabetes type II, and other articles have been used. We excluded other articles, which are not related to this field. The data will be extracted according to specific form in which it is going to be reviewed by t...
"A Study on High Serum Uric Acid Levels in Type Ii Diabetes Mellitus"
IOSR Journals , 2019
Introduction: Uric acid is the most abundant of antioxidant in plasma.Hyperuricemia associated withblood glucose reflects the role of hyperglycemia in the production of oxidative stress in the Type II DM patients.Material and Methods:Total 150 subjects were studied and divided into three groups, depending upon their glycosylated hemoglobin level:-Group 1 (Normal subjects): 50 patients with HbA1c level <6%, Group 2 (Well controlled diabetes): 50 patients with HbA1c level 6-8% and Group 3 (Poorly controlled diabetes): 50 patients with HbA1c level >8%.Serum uric acid levels were measured using Uricase-PAP Method.Results: High uric acid levels were found in poorly controlled group (7.12±0.57), compared to normal (1.96±0.52) and well controlled group (4.71±0.29), which is statistically highly significant(<0.0001). Conclusion:Prevalence of hyperuricemia has a key role in progression of Type II Diabetes Mellitus.
Status of serum uric acid in diabetic and non-diabetic subjects
The Professional Medical Journal
Diabetes Mellitus is a chronic metabolic disorder which occurs due to absolute or relative deficiency of insulin hormone and the diabetic patients are more prone to develop stroke, heart attack, kidney failure, blindness, coronary artery disease, neuropathy and gangrene. Increased uric acid levels in serum are one of the metabolic abnormalities associated with diabetes mellitus type 2. Objectives: The purpose of the research is to assess the status of serum uric acid in non-diabetic and diabetic subjects. Study Design: Cross Sectional Comparative study. Setting: Department of Medicine Jinnah Postgraduate Medical Center, Karachi. Period: Feb 2018 till September 2018. Material & Methods: A total of 80 subjects of both sexes were taken and divided into two groups. Fasting glucose levels, serum uric acid were performed by enzymatic method. Results: This study showed significantly raised levels of serum uric acid and Fasting blood glucose (FBS) in diabetic type 2 subjects when compared t...
Relevance of uric Acid in progression of type 2 diabetes mellitus
Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences, 2010
Recent studies have introduced serum uric acid (UA) as a potential risk factor for developing diabetes, hypertension, stroke, and cardiovascular diseases. The value of elevated levels of UA in serum as a risk factor for diabetes development is still under scrutiny. Recent data suggest that clearance of UA is being reduced with increase in insulin resistance and UA as a marker of prediabetes period. However, conflicting data related to UA in serum of patients with Type 2 diabetes prompted us to study the urine/serum ratio of UA levels (USRUA) in these patients and healthy controls. All subjects included in the study were free of evidence of hepatitis B or C viral infection or active liver and kidney damage. Patients receiving drugs known to influence UA levels were also excluded from this study. Analysis of glucose and uric acid were performed on Dade Behring analyzer using standard IFCC protocols. Interestingly, our data demonstrated about 2.5 fold higher USRUA values in diabetic pa...
correlation of serum uric acid levels with type II diabetic patients
International journal of health sciences
Aim: To correlate diabetes patients' blood uric acid levels with their duration of diabetes. Materials and methods: This study was conducted on 100 diabetic patients(30-50 years).diabetic patients with no history of any other systemic complications and metabolic disorders like obesity and gout . Each diabetic patient was subjected to detailed general examination. A biochemical investigation for fasting serum uric acid levels estimated. Results: A positive correlation present between SUA and duration of type 2 diabetes is statistically significant. As the duration of diabetes increases than there is an increase in the serum uric acid concentration in type 2 diabetes patients (r = +0.630,p<0.001). Conclusion: Drugs that reduce the serum uric acid level may become effective in preventing the development and prognosis of insulin resistance, a major factor in type 2 diabetes. The significant positive correlation between serum uric acid and the duration of type 2 diabetes suggests ...
Association of blood uric acid with the duration of diabetes in type 2 diabetics: A pilot study
Indian Journal of Clinical Anatomy and Physiology
Diabetes Mellitus is the most common non-communicable disease which is vastly conquering both the developed & developing countries of the world. Hypothesis: serum uric acid plays as an independent risk factor for the development of type 2 diabetes. Studies revealing the clearance of uric acid reduced with insulin resistance are few in numbers. A positive correlation between uric acid and glucose levels leads to the development of type 2 diabetes. Objective: To correlate the levels of blood uric acid with the duration of diabetes in type 2 diabetics. Materials and Methods: Fifteen type 2 diabetes patients with no history of any complications and other systemic organ & metabolic disorders like gout & obesity randomly selected for this cross-sectional study. A biochemical investigation, like the Uricase method employed for fasting serum uric acid levels estimation. Statistical analysis by the Pearson correlation test used. Results: Positive correlation of serum uric acid with the duration of diabetes in type 2 diabetic patients found to be statistically significant (r = +0.6, p < 0.05). Out of fifteen, eleven of them were suffering from hyperuricemia (73%). Average uric acid level elevated from 6.88 ± 0.95 in people with the duration of diabetes 2 to 6 years to 7.61 ± 3.16 in people with the duration of diabetes 7 to 10 years. Conclusion: The positive association of fasting serum uric acid with the duration of type 2 diabetes suggests that uric acid acts as an independent biochemical marker for prognosis of the type 2 diabetes. Drugs that reduce the uric acid levels may be useful in avoiding the development and prognosis of insulin resistance that causes type 2 diabetes and other complications.
Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients
Nepal Medical College journal, 2022
Uric acid increases insulin resistance; likewise, hyperinsulinemia increases uric acid concentration, and both are global health problems. This study is conducted to find the association between serum uric acid and blood glucose level. This was a cross-sectional study conducted in the Department of Biochemistry and Internal Medicine at Dhulikhel Hospital, Nepal, for a duration of six months (September 2021-February 2022). A total of 130 diabetic patients who consented were compared with 130 non-diabetics by using non-probability convenient sampling technique. Ethical clearance was taken from the Institutional Review Committee-Kathmandu University School of Medical Sciences. Venous blood was collected and fasting blood glucose, post-prandial blood glucose, and serum uric acid were measured. Data were analyzed in the Statistical Package for Social version 16.0. Analytical data were compared using Mann Whitney U test, and Spearman correlation was performed to correlate numerical parameters. Statistical significance was defined as a two-sided p-value of less than 0.05. The median of serum uric acid level was significantly higher in diabetics than non-diabetics; the level of fasting and postprandial blood glucose positively correlated with serum uric acid (p<0.05). Hyperuricemia was more in diabetics than non-diabetics (p<0.05). Serum uric acid level increased with the increase in age and duration of diabetes.
JOURNAL OF RANGAMATI MEDICAL COLLEGE, 2022
Background: Recent studies have identified serum Uric Acid (UA) as a potential risk factor for developing diabetes, hypertension, stroke, and cardiovascular diseases. However, thechanges in serum uric acid concentrations and its possible link with components of metabolic syndrome in patients with type 2 diabetes mellitus is still under scrutiny. So, the aim of the present study was to investigate the serum uric acid concentrations in type 2 diabetes patients its relations with components of metabolic syndrome i.e., fasting lipids, plasma glucose and BMI. Materials and methods: This case-control study was conducted in the Department of Biochemistry, Chittagong Medical College, Chattagram over a period 1 year from July 2013 to June 2014. Sixty (60) type II diabetic cases presenting in Chittagong Medical College Hospital and forty (40) healthy controls from community were included. Fasting plasma glucose, fasting lipid profile, postprandial plasma glucose, serum uric acid and serum creatinine were estimated in automated clinical chemistry analyser. Relevant statistical tests of significance were done as needed. Results: The mean serum uric acid was higher in type 2 diabetic patients compared to that of healthy control subjects (7.25 ± 0.46 mg/dL vs 4.49 ± 0.57 mg/dL, p < 0.005). Uric acid showed a positive correlation with plasma glucose, serum total cholesterol, LDL cholesterol, triacylglycerol and BMI and also a negative correlation with HDL cholesterol. Conclusion: In conclusion, serum uric acid concentrations were significantly higher in diabetic patients compared to their healthy counterparts. Levels of serum uric acid also showed significant correlation with fasting lipids, plasma glucose and BMI. So, estimation of serum uric acid is of good value in prognostic and metabolic evaluation of type 2 diabetes patients.
Uric acid and glucose metabolism in uncomplicated Libyan diabetic patients
Uric acid has increasingly been associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Diabetic patients who are hyperuricemic have a risk of developing diabetic complications. Pathogenesis of uric acid may decrease nitric oxide bioavailability in vascular smooth muscle, endothelial cells and direct scavenging of nitric oxide by uric acid. A decrease in endothelial nitric oxide production by uric acid has also been associated with endothelial dysfunction and insulin resistance. This study aims is to determine the relationship between uric acid and glucose levels in patients with type 2 diabetes mellitus. The study included 161 Libyan patients (67 males and 94 females) diagnosed with type 2 diabetes mellitus. Both levels of serum uric acid and hemoglobin A1c (HbA1c) were determined. The patients were divided into two groups. The controllable diabetic group with HbA1c of less than 06.0% and the uncontrollable diabetic group with HbA1c of more than 06.0%. Patients who are suffering from type 2 diabetes mellitus without complications were included whereas patients with smoking, alcoholism, nephrotic disease, malignancy, hepatitis, and renal failure or kidney disease were excluded. The mean and standard deviation of uric acid, HbA1c and Pearson correlation coefficient test were considered. In the controllable diabetic group, serum uric acid mean was found to be 4.807 ± 1.39 and HbA1c was found to be 5.032 ± 1.39. In the uncontrollable diabetic group, serum uric acid was 4.897 ± 1.66 and HbA1c was 8.396 ± 1.65. Uric acid level has significantly been correlated with HBA1C in controlled and uncontrolled diabetic patients (p < 0.05). In addition, the uric acid level was found to be higher in uncontrolled diabetic group than that in the controlled group (p < 0.05). A possible relationship between serum uric acid and incidence of type 2 diabetes mellitus was noted. Thus, uric acid can be used as a potential biomarker to indicate impaired glucose metabolism.
Serum Uric Acid in Diabetic and Non-Diabetic Subjects
2020
Material & Methods: A total of 80 subjects of both sexes were taken and divided into two groups. Fasting glucose levels, serum uric acid were performed by enzymatic method. Results: This study showed significantly raised levels of serum uric acid and Fasting blood glucose (FBS) in diabetic type 2 subjects when compared to non-diabetic subjects(p<0.01). Conclusion: The results of the present study suggests that compared to non-diabetic subject's diabetic subjects have significantly higher level of uric acid.