Visceral leishmaniasis-associated nephropathy in hospitalized Brazilian patients: new insights based on kidney injury biomarkers (original) (raw)

Visceral leishmaniasis-associated nephropathy in hospitalized Brazilian patients: new insights based on kidney injury biomarkers

To evaluate the usefulness of early acute kidney injury (AKI) biomarkers in clinical management of visceral leishmaniasis. Prospective study with 50 hospitalized VL patients. AKI biomarkers, i.e., serum and urinary Neutrophil Gelatinase-associated Lipocalin (sNGAL, uNGAL, respectively), urinary Kidney Injury Molecule-1 (uKIM-1) and urinary monocyte chemotactic protein-1 (uMCP-1) were quantified by immunoassay (ELISA). Also, interferon-gamma (INF-y) and C-reactive protein (CRP) were evaluated as inflammatory biomarkers possibly related to VL severity. VL patients had hyponatremia, hypoalbuminemia, hypergammaglobulinemia, hematologic and hepatic disorders. AKI was found in 46%, and 1 death (2%) occurred. The AKI group had significant longer hospital stay, lower levels of IFN-y and higher levels of CRP, more clinical renal abnormalities and higher levels of sNGAL, uNGAL, uKIM-1 and uMCP-1. Overall, sNGAL, uKIM-1 and uMCP-1 showed correlations with important clinical renal abnormalities...