Intrahepatic Fat, Abdominal Adipose Tissues, and Metabolic State; Magnetic Resonance Imaging Study (original) (raw)

Diabetes/Metabolism Research and Reviews, 2017

Abstract

Intrahepatic-fat (IHF) is best known to associate with waist circumference (WC) and visceral-adipose-tissue (VAT), but its relation to abdominal subcutaneous-adipose tissue (SAT) is controversial. While IHF > 5% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat sub-depots, pancreatic and renal-sinus fats. We evaluated %IHF, abdominal fat sub-depots, %pancreatic and renal-sinus fats, among individuals with moderate abdominal obesity, using 3-T magnetic resonance imaging (MRI). Among 275 participants, %IHF widely ranged (0.01%-50.4%) and was lower in women (1.6%) than men (7.3%; p < 0.001). In an age, sex, and WC-adjusted models, VAT area (p < 0.006) was directly associated with %IHF, while superficial-SAT proportion was inversely associated with %IHF (p < 0.006). In these models, renal-sinus fat was positively associated with %IHF (p = 0.005). In an age, sex, WC, and VAT-adjusted models, elevated liver enzymes, glycemic, lipid, and inflammatory biomarkers were associated with increased %IHF (p < 0.003 for all). In these models, the associations remained robust even within the normal range strata of IHF < 5% for triglycerides and chemerin (p ≤ 0.004 for all). For the diagnosis of fatty liver, the joint Area Under the Curve of WC, alanine-aminotransferase, triglycerides/HDL-c and homeostasis-model-assessment of insulin resistance (HOMA-IR) was 0.84(95% CI 0.79-0.89). Intrahepatic-fat is differentially associated with abdominal fat sub-depots. Intrahepatic-fat as a continuous variable could be predicted by specific traditional parameters, even within the current normal range, and partially independent of VAT.

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