Decreased levels of coenzyme Q10 in patients with bronchial asthma (original) (raw)
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Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma
Annals of Thoracic Medicine, 2012
CONTEXT: Asthma is a chronic airway disorder which is associated to the inflammatory cells. Inflammatory and immune cells generate more reactive oxygen species in patients suffering from asthma which leads to tissue injury. AIMS: To investigate the role of oxidant-antioxidant imbalance in disease progression of asthmatic patients. SETTINGS AND DESIGN: In this study, 130 asthmatic patients and 70 healthy controls were documented. METHODS: For this malondialdehyde level, total protein carbonyls, sulfhydryls, activity of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), total blood glutathione, and total antioxidant capacity (FRAP) were measured. STATISTICAL ANALYSIS USED: Analysis of the data was done using unpaired student t test and one-way ANOVA analysis. P < 0.05 was considered significant. RESULTS: The present work showed that the systemic levels of MDA (4.19 ± 0.10 nmol/ml, P < 0.001) and protein carbonyls (1.13 ± 0.02 nmol/mg, P < 0.001) were found to be remarkably higher in asthmatic patients while protein sulfhydryls (0.55 ± 0.01 mmol/l, P < 0.05) decreased as compared to controls (2.84 ± 0.12 nmol/ml, 0.79 ± 0.02 nmol/ mg and 0.60 ± 0.02 mmol/l, respectively). We also observed decrease in activities of SOD (2047 ± 50.34 U/g Hb, P < 0.05), catalase (4374 ± 67.98 U/g Hb, P < 0.01), and GPx (40.97 ± 1.05 U/g Hb, P < 0.01) in erythrocytes compared to control (2217 ± 60.11 U/g Hb, 4746 ± 89.94 U/g Hb, and 48.37 ± 2.47 U/g Hb, respectively). FRAP level (750.90 ± 21.22 µmol/l, P < 0.05) in plasma was decreased, whereas total blood glutathione increased (0.94 ± 0.02 mmol/l, P < 0.05) as seen in control (840.40 ± 28.39 µmol/l and 0.84 ± 0.04 mmol/l). CONCLUSIONS: This work supports and describes the hypothesis that an imbalance between oxidant-antioxidant is associated to the oxidative stress which plays a significant role in severity of the disease.
Study of Serum Oxidant-Antioxidants Status in Adult Bronchial Asthmatics
TOFIQ Journal of Medical Sciences, 2015
Asthma is a chronic inflammatory airway disorder associated with recruitment of inflammatory cells. Asthmatic patients produce reactive oxygen species damaging the antioxidant defense system and forming a state of oxidative stress in asthmatics. The present study included 50 patients [25 males and 25 females] and 50 supposed healthy subjects (control) [25 males and 25 females]. The results show a presence of a significant increase (p ≤ 0.05) in malondialdehyde (MDA) and ceruloplasmin (Cp) levels in both sexes of bronchial asthmatic (BA) patients in contrast with the control group. On the other hand, transferrin (Tf) showed a significant decrease (p ≤ 0.05) in male BA patients compared with the control group, whereas, serum Tf levels demonstrated a non-significant decrease among the female BA patients in comparison with the control group. Correlation coefficient (r) test is used to describe the association between lipid peroxidation products and different antioxidants. This study re...
Leukocyte Oxidant and Antioxidant Status in Asthmatic Patients
Archives of Medical Research, 2005
Background. Oxidative stress mediated by reactive oxygen species (ROS) is recognized to contribute significantly to the inflammatory process of bronchial asthma (BA). These species are released into the airway by activated inflammatory cells such as leukocytes.
Coenzyme Q10supplementation reduces corticosteroids dosage in patients with bronchial asthma
BioFactors, 2005
Bronchial asthma is a chronic inflammatory disease of respiratory system, with disturbances in the dynamic balance of oxidant-antioxidant capacity of the lungs. Long-term administration of corticosteroids has been shown to result in mitochondrial dysfunction and oxidative damage of mitochondrial and nuclear DNAs. We previously documented decreased coenzyme Q10 (CoQ10) and α-tocopherol concentrations in plasma and blood in corticosteroid-dependent bronchial asthma patients. In the present study we demonstrate that CoQ10 supplementation reduces the dosage of corticosteroids in these patients. Patients and methods: This was an open, cross-over, randomized clinical study with 41 bronchial asthma patients (13 males, 28 females), ages 25-50 years. All patients suffered from persistent mild to moderate asthma. The patients were divided into two groups, one group receiving standard antiasthmatic therapy and clinically stabilized, and the second group receiving, in addition, antioxidants consisting of CoQ10 as Q-Gel (120 mg) + 400 mg α-tocopherol + 250 mg vitamin C a day. The groups were crossed over at 16 weeks for a total duration of 32 weeks. Results and conclusions: Data show that patients with corticosteroid-dependent bronchial asthma have low plasma CoQ10 concentrations that may contribute to their antioxidant imbalance and oxidative stress. A reduction in the dosage of corticosteroids required by the patients following antioxidant supplementation was observed, indicating lower incidence of potential adverse effects of the drugs, decreased oxidative stress. This study also demonstrates the significant uptake of CoQ10 by lung tissue in a rat model using hydrosoluble CoQ10 (Q-Gel).
Therapeutic advances in respiratory disease, 2008
Prevalence of asthma has increased considerably in recent decades throughout the world especially in developed countries. Airway inflammation is thought to be prime cause for repeated episodes of airway obstruction in asthmatics. Several studies have shown that reactive oxygen species (ROS) play a key role in initiation as well as amplification of inflammation in asthmatic airways. Excessive ROS production in asthma leads to alteration in key enzymatic as well as nonenzymatic antioxidants such as glutathione, vitamins C and E, beta-carotene, uric acid, thioredoxin, superoxide dismutases, catalase, and glutathione peroxidases leading to oxidant-antioxidant imbalance in airways. Oxidant-antioxidant imbalance leads to pathophysiological effects associated with asthma such as vascular permeability, mucus hypersecretion, smooth muscle contraction, and epithelial shedding. Epidemiological data also support the scientific evidence of oxidant-antioxidant imbalance in asthmatics. Therefore, ...
Oxidants and Antioxidants Status in Bronchial Asthma
Asthma is a respiratory disease that is common in Saudi Arabia and characterized by sporadic occurrence of bridge, chronic inflammation of the airways involving recurrent airflow obstruction and increased responsiveness to a variety of stimuli. Recent research suggests that airway inflammation is the most cause of the episodes of airflow limitation in asthma which lead to increase oxidative stress. This imbalance between oxidant and antioxidant has been increasingly recognized as a big factor contributing to the chronic inflammation. Therefore, the aim of this review is to describe the role and origin of the oxidant-antioxidant disturbances that participate in the pathophysiology of airway inflammatory diseases. We have updated existing information about effects (effects of oxidants in the lung) of reactive oxygen and nitrogen species in the lung including the mechanisms of their damaging effect. The first section focuses entirely on the symptoms, the types and stages of bronchial asthma. The second section investigates the role of oxidant-antioxidant imbalance in disease progression of asthma. The last section outlines the therapeutic value of available antioxidant herbals and vitamins that could improve oxidant-antioxidant balance in bronchial asthma disease.
Biomarkers of oxidative stress in acute and chronic bronchial asthma
Objective: Oxidative stress plays an important role in inflammatory diseases of the airways, such as bronchial asthma. This study highlights the effects of the imbalance of oxidant/antioxidant parameters and their roles in the severity of asthma, in order to target the deficiency of antioxidants when treating asthmatic patients. Methods: The study included 45 male and 45 female subjects, aged 18–48 years, with and without asthma. They were classified into 3 groups: G1 was healthy volunteers (CT, n ¼ 15), G2 included patients with stable (chronic) conditions of asthma from the outpatients department (OP, n ¼ 15), and G3 included patients admitted emergency room (ER, n ¼ 15) with acute asthma attacks. For all subjects, the levels of total antioxidant capacity (TAC), reduced glutathione (GSH), malondialdehyde (MDA), and uric acid were colorimetrically estimated. The correlations between the studied parameters were statistically analyzed. Results: The levels of TAC and GSH in asthmatic patients, either male or female, were significantly decreased in the ER more than in the OP group as compared to the control (p50.001). MDA increased significantly in the ER group and over the OP group when compared with healthy subjects. Significant positive correlations (p50.001) were observed between MDA and other studied parameters TAC (r ¼ À0.74), GSH (r ¼ À0.69), and uric acid (r ¼ À0.35). Conclusions: The levels of total antioxidants were inversely related to the severity of asthma as observed in asthmatic patients visiting outpatient clinics and patients with acute asthmatic attacks admitted to emergency rooms. Meanwhile, those patients with acute attacks showed increased oxidative stress as reflected in the raised MDA levels.
Background: Asthma is a chronic disorder of the airways. Oxidative stress is an important part of asthma pathogene-sis. It plays a crucial role in exacerbating the disease, as well as an important consequence of airways inflammation. Aim: The present study was undertaken to investigate the lipid peroxidation and catalase activity in serum and antiox-idant level in plasma of asthmatic patients and their association with lifestyle and severity of the disease. Methods: A total of 210 subjects, 120 asthmatics and 90 healthy controls matched in respect to age, sex, lifestyle and socioeconomic status, were chosen randomly for the present study. The samples were analyzed for MDA concentration and catalase activity in serum and ferric reducing ability of plasma (FRAP). Statistical analysis was done using unpaired Student's t-test, ANOVA with Duncan post hoc test and Pearson coefficient of correlation. Results: The serum MDA was found to be significantly higher in the asthmatics as compared to healthy individuals (p<0.01) while catalase activity in serum and antioxi-dant level of the plasma were markedly lower in the asthmatics as compared to healthy individuals (p<0.01). A significant difference was observed in serum MDA, cata-lase activity and plasma antioxidant level among the patients in relation to the severity of disease. There was a marked increase in the serum MDA in the patients with longer duration of the disease (p<0.05). Conclusions: The oxidant–antioxidant imbalance occurs in asthma leading to oxidative stress and is an important part of the asthma pathogenesis.