EFFECTS OF NATURAL PRODUCTS ON DIABETIC DYSLIPOPROTEINEMIA (original) (raw)
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Biochemistry an Indian Journal
Diabetes mellitus is a metabolic disease characterized by defects in insulin secretion. Allopathic medicines decrease the glucose level by acting on pancreatic beta cells. Indigenous medicines are used to treat diabetes mellitus because, the side effect are less, easy availability and less expensiveness. Trigonella foenum graecum seeds and Caesalpinia bonducella can increase glucose induced insulin release in human and rat pancreatic islets.
Journal of Medicinal Herbs and Ethnomedicine , 2023
The medicinal foods used to manage non-communicable diseases in Sri Lankan traditional medicine are slowly but steadily disappearing from the country due to many reasons. This study is the first stage of the research project aimed to explore and analyze the medicinal foods used to manage dyslipidaemia in traditional medical practices of Sri Lanka. A qualitative study covering the whole island was conducted cross-sectionally, supplemented by a document review including ancient textbooks and talipot palm (Corypha umbraculifera) leaf manuscripts. The study included all the registered traditional medical practitioners of the country, more than 55 years of age. Practitioners with poor memory and feeble health and those who were not in current practice were excluded. The first participant was selected purposively and the rest by using the snowball sampling technique. The investigator administered, validated, openended, semistructured questionnaire was the tool used, and the interviews were conducted face to face or using either telephone, zoom, or WhatsApp technology. The saturation was achieved by the 25 th participant and data were analysed using the framework analysis technique. Nine medicinal foods including three herbal congees, one herbal beverage, one green leaf salad, and four curry preparations with antidyslipidaemic effects were explored. Sri Lankan native medicine possesses many medicinal foods with antidyslipidaemic effects and they should be explored, scientifically studied, and used as evidence-based management for the smooth control of diabetes mellitus.
Diabetes is a major public health problem that is approaching epidemic proportions globally. Worldwide the prevalence of chronic, non-communicable diseases is increasing at an alarming rate. Cardiovascular diseases (CVDs) are the major causes of mortality in persons with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD. Hypertension is approximately twice as frequent in patients with diabetes compared with patients without the disease. Conversely, recent data suggest that hypertensive persons are more predisposed to the development of diabetes than are normotensive persons. Co-existence of diabetes mellitus and hypertension increases the risk of macro-and micro-vascular complications. In this review attempt has been made to explore the risk factors which can be helpful to prevent hyperglycemia and related manifestation of Type 2 diabetes. Both biochemical and genetic diagnostic markers identified till now have been catalogued to describe the status of pathogenesis in hyperglycemic subjects.
Indian Journal of Endocrinology and Metabolism
Objective: Extracts from various morphological parts of Cryptolepis sanguinolenta are widely used traditionally in folklore medicine in many parts of the world for the management, control, and/or treatment of a plethora of human ailments, including diabetes mellitus. In order to scientifically appraise some of the ethnomedical uses of Cryptolepis sanguinolenta, the present study was undertaken to investigate its influence at varying doses on intestinal glucose absorption and transport in relation to its hypoglycemic and hypolipidemic effects in rat experimental paradigms. Materials and Methods: The animals used were divided into four groups. Control animals received 2 ml of distilled water, while treated groups received 50, 150, and 250 mg/kg bw of Cryptolepis sanguinolenta extract per oral respectively daily for 21 days. Results: Cryptolepis sanguinolenta led to a significant decrease in glucose transport and absorption. It also caused significant reductions in plasma glucose, total cholesterol, triglyceride, and LDL cholesterol. Biochemical changes observed were suggestive of dose dependence. Histopathological studies also showed increased sizes of β cells of the pancreas. Conclusion: The findings in these normoglycemic laboratory animals suggest that Cryptolepis sanguinolenta has hypoglycemic and hypolipidemic activities, possibly by reducing glucose absorption and transport, and enhancing the structural and functional abilities of the β cells. This is the first study to report the effect of Cryptolepis sanguinolenta on intestinal glucose absorption. This effect could be attributed to its major bioactive principle, cryptolepine, an indoloquinoline alkaloid. This study thus lends credence to the use of Cryptolepis sanguinolenta in the management of diabetes mellitus.
Study on use of Indigenous herbal product by diabetic patient visiting diabetic centre in Nepal
Janaki Medical College Journal of Medical Science, 2016
Background and Objectives: Diabetes Mellitus (DM) is a chronic disease worldwide. With increasing trends towards sedentary lifestyle, the prevalence of diabetes mellitus is increasing in urban region of Nepal too. Material and Methods: A quantitative descriptive study was conducted for a period of two months. One-to-one structured interviews were taken to fill the structured questionnaire prepared after proper literature review from the patients attending a diabetic clinic in Lalitpur. The questionnaire includes the socio-demographic details, lifestyle and questionnaires related to patients' perception and use of herbal remedies/product. Relevant information was also obtained from the patient medical files. Statistical analysis was performed by using SPSS version 20. Results: Out of total population about 30 % of people were using the indigenous product for their treatment along with allopathic medication. Among them, 17 were male and 14 were female. Various indigenous herbal products were used by the patients. Among them fenugreek, aloe Vera, bitter guard, bottle guard, black berry are the common one. The frequencies of using these products are in fig 4.4. The total percentage of patient using fenugreek is 42%, Aleo-Vera 35%, Bittergaurd 29% and very few participants were using Bottle guard, Neem, and Hibiscus and Guava leaf too. Conclusion: Participants have good faith on use of indigenous herbal products and are using it. Fenugreeks, Aloe-Vera, Bittergourd, Neem, Bottle gourd, Hibiscus and Guava leaf are commonly used. But no consistent data regarding fixed dose or method of preparation of such product was found. So, further researches are needed to confirm the effectiveness of those indigenous products.
Antidiabetic effect of some commonly used medicinal plants from Pakistan
Journal of Biotechnological Sciences , 2021
The aim of the present study was to investigate the in vitro and in vivo antidiabetic effect of Elaeagnus umbellata, Phyllanthus emblica and Cannabis sativa. The in vitro antidiabetic activity was studied by the inhibition of alpha glucosidase enzyme. The in vivo antidiabetic activity was studied in albino mice. The diabetes was induced in mice by single interperitoneal injection of alloxan (150 mg/kg). The hot water extracts were fed to the mice orally (250 mg/kg) for seven days. The order of alpha glucosidase inhibitory effect was P. emblica > E. umbellata > C. sativa. The in vivo antidiabetic activity of extracts was further confirmed in alloxan induced diabetic mice. The Normal mice showed glucose level of 110±5 mg/dl. On treatment with single dose of alloxan (150 mg/kg) the sugar level was elevated to 250±10 mg/dl. The treatment with aqueous extract of E. umbellata fruit for seven days reduced the glucose level to 220±10 mg/dl. On the other hand treatment with aqueous extracts of P. emblica and C. sativa reduced the glucose level to 170±11 mg/dl and 185±12 mg/dl respectively. On the basis of these results it is concluded that studied plants have potential to decrease the glucose level by inhibiting the alpha glucosidase enzyme and potentiating of insulin release from pancreas. This will leads to the development of alternative drugs and therapeutic strategies.
GLOBAL CURRENT TRENDS IN NATURAL PRODUCTS FOR DIABETES MANAGEMENT: A REVIEW Review Article
International Journal of Pharmacy and Pharmaceutical Sciences, 2016
Diabetes mellitus is a major health problem in the world. There is no cure for diabetes. It is, therefore, essential to practice effective methods of the diagnosis, treatment, and management of diabetes. With the increase in a number of newer drugs for diabetes, there is the possibility of a wide range of side effects that vary from one drug to another. Hence, the need to explore oral antidiabetic drugs of natural origin with minimal side effects is highly essential. This review provides a scientific perspective on the usage and research of natural and Indian traditional remedies in the management of diabetes while also providing insight into the advances in our understanding of diabetic pathology.
Diabetes mellitus (DM) affects 150 million people worldwide including 50 million in India. The incidence rate of the disease is expected to double by 2025. Diabetes emerges due to several factors such as inhibition of glucose absorption, increase in glucose uptake and upregulation of glucose transporters, activation of the nuclear receptor PPAR , increase in adiponectin release, glycogen metabolism, absent or decreased insulin production and/or impaired function, insulin mimetic and insulinotropic effect, elevation of D-Chloroinositol, incretin mimetics and incretin enhancers, and the role of endogenous opioids on glucose homeostasis and antioxidants. Based on the pancreatic effect, DM is classified as type 1 (insulin dependent diabetes mellitus (IDDM)) and type 2 (noninsulin dependent diabetes mellitus (NIDDM)). DM induced hyperglycemia leads to many clinical complications either at the macrovascular level causing coronary artery and cerebrovascular diseases or at the microvascular level causing renal failure, blindness, limb amputation, neurological complications, and premature death . The symptoms of DM include severe hypoglycemia, lactic acidosis, idiosyncratic liver cell injury, permanent neurological deficit, digestive discomfort, headache, and dizziness.
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