Computer-Assisted Image Analysis of the Rat Postosteonecrotic Remodeled Femoral Head (original) (raw)

2001, Experimental and Molecular Pathology

Osteonecrosis of rat femoral heads was induced by stripping the head that could rightfully be applied to experimental exploraperiosteum of the neck and cutting the ligamentum teres. The epiphyseal tion of treatment modalities premised to hinder or halt the marrow and bone were necrotic on the 5th postoperative day. Specimens progression of the disease in man. A review of the literature obtained 18 and 36 days postoperatively showed fibrous and hematopoion avascular osteonecrosis in animals was published recently etic-fatty tissue in the intertrabecular spaces, osteoclastic bone resorption, osteogenesis, and degeneration of the joint cartilage. Morphomet-(Boss and Misselevich, 2001). We examined rat necrotic rically, the means of the height-to-length ratios of the control, 6-day, femoral heads after vascular deprivation induced by strip-18-day, and 36-day femoral heads were 0.26, 0.28, 0.48, and 0.29, ping the periosteum of the neck and cutting the ligamentum respectively. The shape factor of the femoral heads of the control rats teres: Histologically, necrosis of the hematopoietic-fatty was higher than 0.81 in 80% of the cases, while those of rats killed marrow set in on the second postoperative day. Necrosis of on the 6th, 18th, and 36th postoperative day were higher than 0.81 in 65, 60, and 50% of cases, respectively. Statistically, the means of the the subchondral and trabecular bone was apparent on the height-to-length ratios and the values of the shape factors of the femoral fifth postoperative day. First evident during the second postheads of the rats killed 18 days postoperatively differed significantly operative week, sequentially evolving repair processes led from those of the other three groups of rats. The quantitatively gauged to remodeling of the epiphysis and, often, also of the metaphdata of the remodeled epiphyses negate the authors' subjective impression concerning early flattening of the femoral heads after surgically ysis: Granulation tissue invaded the intertrabecular spaces produced osteonecrosis. ᭧ 2001 Elsevier Science from the inflamed joint capsule, macrophages and osteoclasts Key Words: osteonecrosis of the femoral head; Perthes disease; removed the necrotic debris, fibroblasts produced fibrous architectural remodeling of the femoral head; animal model of human tissue, which was repopulated by hematopoietic and fat cells, disease; computer-assisted image analysis. and, eventually, the osteoblasts deposited appositional and intramembranous bone. This remodeling resulted in architectural distortion of the epiphysis and physis, a shift from spongy to near compacta-type bone, and degeneration of the