Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments (original) (raw)

Eukaryotic cells utilize the actin-related protein 2/3 (Arp2/3) complex for the nucleation of actin filaments, essential for cellular motility. Prior research suggests that phosphorylation of the Arp2/3 complex may enhance motility, yet its direct role in regulating the actin nucleating activity remains unverified. This study investigates the necessity of phosphorylation for the nucleation process of the Arp2/3 complex, revealing critical insights into its regulation and implications for cell motility.