The impact of renal transplantation on survival in hepatitis C-positive end-stage renal disease patients (original) (raw)

1997, American Journal of Kidney Diseases

Impact of renal transplantation on survival in end-stage renal In the general population, obesity is defined as a body disease patients with elevated body mass index. mass index (BMI) Ն30 kg/m 2 , and is associated with Background. Cadaveric renal transplantation is associated higher rates of hypertension, diabetes, cardiovascular with a survival advantage compared with dialysis patients redisease, and premature death [1, 2]. Among renal transmaining on the renal transplantation waiting list, but this advanplant recipients, obesity either at the time of or after tage has not been confirmed in obese end-stage renal disease (ESRD) patients. renal transplantation has been associated with shortened Methods. Using data from the USRDS, we studied 7521 allograft and patient survival [3, 4], although the results patients who presented with ESRD from 1 April 1995 to 29 are conflicting [5]. Obesity is among the reasons end-June 1999 and later enrolled on the renal transplantation waitstage renal disease (ESRD) patients are not placed on ing list with body mass indices (BMI) Ն30 kg/m 2 at the time the renal transplant waiting list, albeit with considerable of presentation to ESRD, and followed until 6 November 2000. Recipients of preemptive renal transplantation or organs other variation by center [6]. However, obesity also has been than kidneys were excluded. Cox non-proportional hazards shown to be associated with improved survival among regression models were used to calculate adjusted, time-depenpatients on maintenance dialysis, compared to patients dent hazard ratios (HR) for time to death in a given patient who are non-obese [7-9]. during the study period, controlling for renal transplantation, Because of the above observations, the survival benefit demographics and comorbidities (Form 2728). Results. The incidence of mortality was 3.3 episodes per 100