Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice (original) (raw)
2000, Proceedings of the National Academy of Sciences
AI-generated Abstract
IL-1 receptor antagonist (IL-1Ra) has been found to have significant anticonvulsant properties in the mouse hippocampus. This study demonstrates that both recombinant IL-1Ra application and endogenous overexpression in astrocytes can inhibit motor and electroencephalographic seizures triggered by bicuculline methiodide, specifically through IL-1R type I mediation. The findings highlight the crucial balance between IL-1 and IL-1Ra in modulating seizure activity, indicating potential therapeutic avenues for managing seizures.
Sign up for access to the world's latest research.
checkGet notified about relevant papers
checkSave papers to use in your research
checkJoin the discussion with peers
checkTrack your impact
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.