Atypical ductal hyperplasia, ductal carcinoma in situ and in situ atypical apocrine proliferations of the breast (original) (raw)
Current Diagnostic Pathology
Atypical epithelial proliferations of the breast are now seen more often by histopathologists as a result of mammographic breast screening programmes and, on occasion, these lesions may cause significant diagnostic and clinical difficulties. Perhaps in part, because of the greater frequency of identification, it has been recognized that there are imperfections in the criteria used to define atypical ductal hyperplasia (ADH). It is also becoming more widely accepted that ductal carcinoma in situ (DCIS) of the breast is a heterogeneous disease and several systems for subtyping this lesion have been described. We aim here to describe the histopathological features of ADH and DCIS, and to address these recent changes in criteria for diagnosis and classification. In addition we review the appearances of atypical apocrine proliferations which may cause particular difficulties with regard to classification.
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