IL-12-Independent IFN-  Production by T Cells in Experimental Chagas' Disease Is Mediated by IL-18 (original) (raw)

2001, The Journal of Immunology

AI-generated Abstract

The study investigates the role of IL-18 in the production of interferon-gamma (IFN-␥) by T cells during experimental Chagas' disease, particularly in the context of IL-12 deficiency. Findings demonstrate that IL-12p35-deficient mice, despite their increased susceptibility to Trypanosoma cruzi infection, produce IFN-␥ independently of IL-12, relying instead on IL-18. The results reveal that CD4+ T cells are the source of this IL-18-mediated IFN-␥ production. Neutralization of IL-18 in vivo confirms its critical role, suggesting potential therapeutic insights for managing Chagas' disease and other related infections.