Systematic Review on the Definition of Allergic Diseases in Children: The MeDALL Study (original) (raw)
Related papers
Pediatric Allergy and Immunology, 2008
Longitudinal prospective birth cohort investigations of children encompassing frequent interviews by doctors, clinical examinations and tests for sensitization are few (1) but much required in order to describe the natural history of allergic diseases and sensitization. A detailed description of an unselected cohort facilitates the transferability of the results to the general population. The DARC birth cohort study follows prospectively a cohort of unselected children from birth into adulthood. Earlier results from the cohort have been published. The prevalence of allergic diseases and sensitization in the cohort from 0-18 months of age have been thoroughly described (2-5), while the follow up at 36 months focused on food allergy (6, 7). As the first step for coming longitudinal analysis, this paper reports prevalence measures of atopic dermatitis, asthma, rhinoconjunctivitis, food hypersensitivity and urticaria in our cohort of children at 6 yr of age, and describes the pattern of sensitization in children with and without allergic disease.
Paediatrics and Child Health, 2012
This will provide an overview of allergy to facilitate an understanding of the epidemiology, immuno-pathology, and the early life origins of the allergic diseases, which are increasing in prevalence worldwide. This veritable allergy epidemic poses a significant public health burden in both the developed and the developing worlds and makes optimal allergy care in both primary and tertiary settings a priority. A clear body of literature supports the commonly observed evolution of early food allergies and atopic dermatitis to the later development of the airways allergic diseases, namely allergic rhinitis and asthma. The main hypotheses behind these concepts are described. A typical clinical case is discussed in order to highlight this allergic march in the clinical setting and current and future strategies for allergy prevention are explored.
Allergy from infancy to adolescence. A population-based 18-year follow-up cohort
BMC Pediatrics, 2009
Background Anxious parents have many concerns about the future health of their atopic infants. Paediatricians and primary care practitioners need to seek knowledge on long-term outcomes in order to cope with the increasing caseload of suspected allergy and the concerns of parents. The aim of the study was to assess suspected and diagnosed allergy in infancy as predictors of allergy and asthma in adolescence. Methods Families expecting their first baby and making their first visit to a maternity health care clinic in 1986 were selected as the study population in a random sample. There were 1278 eligible study families. The data were provided of the children at the ages of 9 and 18 months and 3, 5, 12, 15 and 18 years by health care professionals, parents, and adolescents (themselves). Results At the age of 9 months, the prevalence of allergy suspicions was distinctly higher than that of allergy diagnoses. At the age of five years suspected allergy approaches were nil, and the prevale...
Epidemiology and Prevention of Allergy in Children
In this paper we present 94 children affected with atopic dermatitis (AD), aggravated by respiratory allergy, asthma and/or allergic rhinitis (AR). AD is a common disorder, frequently complicated by asthma-like symptoms, we debate either disorder and conclude that both AR and asthma can afflict most babies with AD, especially when both parents smoke. We confirm our previous statistics, according to which little children not fed breast milk may react to smallest doses of allergens.
American journal of epidemiology, 2018
International collaborations among birth cohorts to better understand asthma and allergies have increased in the last years. However, differences in definitions and methods preclude direct pooling of original individual participant data. We harmonized data from 14 birth cohorts, with three to 20 follow-ups, from nine European countries, as part of the Mechanisms of the Development of Asthma and Allergies (MeDALL) project. The harmonization process followed six steps: organization of the harmonization panel; identification of variables relevant to MeDALL objectives (candidate variables); proposal of a definition for each candidate variable (reference definition); assessment of the compatibility of each cohort variable to its reference definition (inferential equivalence) and classifications of this inferential equivalence as complete, partial, or impossible; workshop to agree on the reference definitions and classifications of inferential equivalence; and data preparation and deliver...
International Archives of Allergy and Immunology, 2011
Background: Environmental and lifestyle factors such as breast-feeding and pets seem to affect atopic disease prevalence. We identified risk factors for allergic diseases. Methods: We prospectively followed until the age of 5 years a cohort of 1,223 children born into allergic families, who participated in a randomized placebo-controlled trial of probiotics as preventive against allergic disease. We evaluated the cumulative incidence of allergic diseases with questionnaires and examined all children at the ages of 2 and 5 years. Results: Compared to allergy in one parent only, allergy in both parents conferred an increased risk of allergic disease at the ages of 2 (OR 1.64; 95% CI 1.11–2.42, p = 0.013) and 5 (OR 1.83; 95% CI 1.24–2.70, p = 0.002) and at the age of 2 for eczema (OR 1.74; 95% CI 1.17–2.58, p = 0.006). Exclusive breast-feeding over 2 months elevated the risk of eczema at the ages of 2 (OR 1.73; 95% CI 1.15–2.61, p = 0.009) and 5 (OR 1.51; 95% CI 1.03–2.23, p = 0.036). ...
Epidemiological trends of allergic diseases in adolescents
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
To assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in adolescents in the city of Belo Horizonte, Brazil, in 2012 by administering the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, as well as to compare the observed prevalences with those found in studies performed 10 years earlier and employing the same methodology used here. This was a cross-sectional study conducted between May and December of 2012 and involving adolescents in the 13- to 14-year age bracket. Participants were randomly selected from among adolescents studying at public schools in Belo Horizonte and completed the ISAAC questionnaire. Proportions were calculated in order to assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in the sample as a whole, and the chi-square goodness-of-fit test was used in order to compare the prevalences observed in 2012 with those found in 2002. The prevalences of symptoms of asthma...