Rational Design of Hit Compounds Targeting Staphylococcus aureus Threonyl-tRNA Synthetase (original) (raw)

Molecular docking studies for the identifications of novel antimicrobial compounds targeting of staphylococcus aureus

Salah Belaidi

2021

View PDFchevron_right

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors

John Berge

Protein Science, 2001

View PDFchevron_right

Crystal structure ofStaphylococcus aureustyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors

Ceri Lewis

Protein Science, 2001

View PDFchevron_right

New Class of Bacterial Phenylalanyl-tRNA Synthetase Inhibitors with High Potency and Broad-Spectrum Activity

Steven Siegel

Antimicrobial Agents and Chemotherapy, 2004

View PDFchevron_right

Synthesis and Molecular Docking of 2,4,5-TRISUBSTITUTED-1,3-THIAZOLE Derivatives as Antibacterial Agents

Noraslinda muhamad bunnori

Malaysian Journal of Analytical Science, 2019

View PDFchevron_right

Novel potential inhibitor discovery against tyrosyl-tRNA synthetase from Staphylococcus aureus by virtual screening, molecular dynamics, MMPBSA and QMMM simulations

Sako Mirzaie

Molecular Simulation, 2020

View PDFchevron_right

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Murray Brown

Bioorganic & Medicinal Chemistry Letters, 2003

View PDFchevron_right

Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents

Julian Hurdle

Antimicrobial agents and chemotherapy, 2005

View PDFchevron_right

Combined 3D-QSAR and Molecular Docking Analysis of Thienopyrimidine Derivatives as Staphylococcus aureus Inhibitors

Saida Khamouli

Acta Chimica Slovenica, 2021

View PDFchevron_right

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA

Sivakumar Annadurai

Bioorganic & Medicinal Chemistry Letters, 2012

View PDFchevron_right

Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA

Dennis S Monteleone

View PDFchevron_right

Molecular Docking Studies of Wide Spectrum Targets in Staphylococcus aureus - An Aim towards Finding Potent Inhibitors

Radha Krsn

Advanced Techniques in Biology & Medicine, 2014

View PDFchevron_right

Computational drug designing of newly synthesized triazoles against potential targets of methicillin resistant Staphylococcus aureus

Humaira Nadeem

2017

View PDFchevron_right

Aminoacyl-tRNA synthetase inhibitors as antimicrobial agents: a patent review from 2006 till present

Bharat Gadakh

Expert Opinion on Therapeutic Patents, 2012

View PDFchevron_right

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

John Berge

Bioorganic & Medicinal Chemistry Letters, 2003

View PDFchevron_right

Hybrid phenylthiazole and 1,3,5-triazine target cytosolic leucyl-tRNA synthetase for antifungal action as revealed by molecular docking studies

Prashant Gahtori

In Silico Pharmacology, 2013

View PDFchevron_right

Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors

Nagakumar Bharatham

Journal of Molecular Graphics and Modelling, 2007

View PDFchevron_right

Docking and PLS Studies on a Set of Thiophenes RNA Polymerase Inhibitors Against Staphylococcus aureus

H. Ishiki, Marcus Scotti, Edeltrudes Lima

Current Topics in Medicinal Chemistry, 2014

View PDFchevron_right

Synthesis, and molecular docking of thiourea derivatives as antibacterial agents targeting enzymes involved in biosynthesis of bacterial cell wall

Tutuk Budiati

Pharmacy education, 2024

View PDFchevron_right

Aminoacyl-tRNA synthetase inhibitors as potential antibiotics

Arthur Van Aerschot

European Journal of Medicinal Chemistry, 2011

View PDFchevron_right

Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: Synthesis, biological evaluation and molecular modeling studies

Leonard Amaral

European journal of medicinal chemistry, 2015

View PDFchevron_right

Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies

Athina Geronikaki

Antibiotics

View PDFchevron_right

The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases

John Finn

Emerging Therapeutic Targets, 2000

View PDFchevron_right

Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors

Bathini Nagendra Babu

Bioorganic & Medicinal Chemistry Letters, 2019

View PDFchevron_right

5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies

ANROOP NAIR

Antibiotics

View PDFchevron_right

Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase

Sergiy Lukashov

Bioorganic & Medicinal Chemistry, 2016

View PDFchevron_right

Novel 4-methylthienopyrimidines as antimicrobial agents: synthesis, docking study and in vitro evaluation

Victoriya Georgiyants

journal of applied pharmaceutical science, 2022

View PDFchevron_right

Promising antibacterial agents against multidrug resistant Staphylococcus aureus

Dr. Srikanth Gatadi

Bioorganic Chemistry, 2019

View PDFchevron_right

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

Satoru Nagatoishi

Scientific Reports, 2015

View PDFchevron_right

Designing of potential inhibitors against Staphylococcus aureus sortase A: Combined analogue and structure based approach with in vitro validation

Pardhasaradhi Mathi

Journal of Molecular Graphics & Modelling, 2015

View PDFchevron_right