Epidemiology of epithelial ovarian cancer: a tertiary hospital based study in Goa, India (original) (raw)
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Introduction: Ovarian cancer is the second most common malignancy in women, the most common cause of gynecologic cancer deaths, and most patients have advanced stage disease at the time of diagnosis. The purpose of this study was to estimate the 5-year survival of patients with epithelial ovarian cancer based on age, tumor histology, stage of disease, and type of treatment. Methods: This study was conducted on 120 patients with epithelial ovarian cancer referred to Shahid Sadoughi hospital and Shah Vali oncology clinic of Yazd from 2006 to 2012. Demographic data and patient records were studied to evaluate the treatment outcome, pathology of the tumor, and stage of disease. Finally, the overall survival rate and tumor-free survival of patients was assessed. Results: The mean patient age was 53.87± 14.11 years. Most participants had stage I (36.7%) or stage II (35%) disease. Serous adenocarcinoma (57.6%) was the most common pathology found in patients with epithelial ovarian cancer. The overall survival of patients in this study was significantly associated with the histological tumor type (p = 0.000) and disease stage (p = 0.0377). Stage I (84.18%) and serous adenocarcinoma (72.81%) demonstrated the best survival. The tumor-free survival rates were not associated with histology types (p = 0.079), surgical procedure (p = 0.18), or chemotherapy (p = 0.18). Conclusion: The survival of patients with epithelial ovarian cancer was significantly associated with disease stage. Serous adenocarcinoma also had the best prognosis among the pathologies studied. Therefore, early detection of ovarian cancer can substantially increase the survival rate.
Ovarian cancer is relatively common but serious and has a poor prognosis. The aim of this study is to highlight the epidemiological, diagnostic, therapeutic and evolutionary aspects of this malignant pathology managed at the Bejaia university hospital center. This is a retrospective and descriptive study over a period of 3 years (2019 - 2022) carried out on 20 patients who developed ovarian cancer. The average age of the patients was 50 years old, 53.23% of whom were over 45 years old. The CA-125 blood test was positive in 18 out of 20 patients. The tumors were discovered on ultrasound in 87.10% of cases and at laparotomy in 12.90%. Total hysterectomy with bilateral adnexectomy was the most performed procedure (64.52%). The early postoperative course was simple. 15 patients underwent second look surgery (16.13%) for locoregional recurrences. Epithelial tumors were the most frequent histological type (93.55%), including 79% in the advanced stage ( IIIc -IV) and 21% in the early stage (Ia- Ib ). Adjuvant chemotherapy was administered in 80% of patients. With a median follow-up of 36 months, 2 patients were lost to follow-up. The evolution was favorable in 27.42% and in 25.81% deaths occurred late postoperatively. Ovarian cancer is not common but serious given the advanced stages and the high rate of late postoperative deaths which were largely observed in patients deprived of adequate neoadjuvant or adjuvant chemotherapy.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017
Background: Ovarian cancer is fast emerging as the leading cancer of the female genital tract. It is the second most common gynecological malignancy in India, but has poor outcomes making it the leading cause of gynecologic cancer related deaths. There is a paucity of data regarding demographic details, patterns of care and outcomes of ovarian epithelial malignancies in India. This is a study to evaluate the demographic details, clinical profile and pathology details of epithelial ovarian cancer registering in atertiary cancer center in Bangalore, Karnataka, India.Methods: This is a retrospective study of the case records of patients diagnosed with epithelial ovarian cancer from January 2012 to December 2014.Results: Malignantovarian tumors constituted 5.6% of all malignancies in women. 84 cases were of epithelial origin constituting 64.4% of all malignant ovarian tumors. 58% of patients were from Karnataka and 25% were from West Bengal. 27% underwent suboptimal surgery outside at p...
South Asian Journal of Cancer
Ovarian cancer is the sixth most common cancer in women worldwide. Patients with ovarian carcinoma mostly present at an advanced stage with serous type of epithelial ovarian cancers, which is the most lethal of all pelvic malignancies. This study aims to critically analyze high-grade serous epithelial ovarian carcinomas in women from the Northeastern region of India and compare our data with Western literature to modify treatment strategies and improve survival outcomes. This hospital-based retrospective analysis involved data from the records of 100 women with high-grade epithelial ovarian cancer treated primarily with neoadjuvant chemotherapy followed by interval debulking surgery in the department of gynecologic oncology at a tertiary level regional cancer institute from January 2018 to December 2019. The demographic, clinical and pathological profile, and survival outcome were evaluated using descriptive statistics. The overall survival of the study population was calculated usi...
Journal of Obstetrics & Gynaecology of Eastern and Central Africa, 2019
Introduction: Ovarian cancer is the third most frequent cause of death amongst gynecological cancers both locally and globally. It presents with vague nonspecific symptoms and is histologically heterogeneous. Ovarian cancer management is primarily surgical followed by adjuvant chemotherapy depending on the histological type and the surgical stage. Objectives: To determine the clinical-pathological presentation, treatment and outcomes of ovarian cancer patients at Moi Teaching and Referral Hospital (MTRH), Eldoret. Methods: This was a retrospective chart review of ovarian cancer patients managed between January 2010 and August 2017 at MTRH. Data were analyzed using STATA version 15. Survival trends were generated using Kaplan Meier method. Results: A total of 124 medical charts of patients with ovarian cancer were retrieved, 29 had incomplete data and were excluded, and 95 were evaluable and included in this review. Over half, (63%) presented in stage 3 and 4 though there was no significant association between histology and stage of disease [X2(6) =4.72, p=0.58]. The median age at diagnosis was 47 years with 55-80 years being the modal age group (36%). Majority (57%) were married and 83.9% were unemployed. Only 66% had documented histopathology, with Epithelial Ovarian Cancer (EOC) being most common (70%), [serous (50%) and mucinous (11.4%)]. Sex cord stromal tumors 11%. Germ cell tumors amounted to 11% (dygerminomas 50%and Yolk sac tumors (25%) Bivariate analysis revealed significant association only between histology and parity [X2 (6) = 28.8, p<0.001]. Those reviewed contributed a total of 138.2 person-years to the study and 11(12%) died, giving a diseasespecific mortality rate of 79.6 per 1,000 person years (95% CI: 44.1-143.8). Mortality was highest among those with epithelial histology 109 (95% CI: 48.8-241.9) per 1,000 person years and those who had neoadjuvant chemotherapy then surgery as a treatment option, 373.1 (95% CI: 93.3-1491.8) per 1,000 person years. Those who underwent upfront surgery followed by adjuvant chemotherapy and sex cord stromal cancer had higher survival probability. Conclusion: Ovarian cancer at MTRH is diagnosed at advanced stages III and IV of disease and has a lower median age at presentation. EOC is the commonest histological type and serous subtype is the most lethal. Mortality was highest among those with EOC and those who underwent neoadjuvant chemotherapy. Granulosa cell tumor is the only sex cord stromal type reported in our setting and it exhibited a higher survival probability. Germ cell tumors were mainly found in nulliparous women.
Ovarian cancer: changes in patterns at diagnosis and relative survival over the last three decades
American Journal of Obstetrics and Gynecology, 2003
OBJECTIVE: The purpose of this study was to examine patterns of diagnosis and relative survival in women who had a diagnosis of primary invasive epithelial ovarian cancer (EOC) from 1973 to 1997, with follow-up through the end of 1999. STUDY DESIGN: From the population-based Surveillance, Epidemiology and End Results (SEER) Program, 32,845 women diagnosed between 1973 and 1997 were used for analysis. The study population was divided in three cohorts based on year of diagnosis and the cohorts were compared with respect to variables of interest by using v 2 tests and relative survival analysis by the life table method. RESULTS: There was an increase in the proportions of minorities diagnosed with EOC, of women 60 years or older at diagnosis, and of women undergoing surgery over time. Survival continuously improved over time, although older patients (60 years or older) and African Americans continued to have the poorest survival. CONCLUSION: Over time, relative survival of women who had primary invasive EOC diagnosed improved. 1,490 (11.05) 1,397 (12.79) *P value represents a v 2 test across periods for differences in proportions for the categorical variables.
International Journal of Community Medicine and Public Health, 2016
Background: One of the leading gynecological malignancies is ovarian cancer. The current study was done to study the histopathological pattern and clinical presentation of ovarian cancer in a tertiary care centre. The objective of the study was to study the clinical presentation, histopathological types of ovarian cancer and the outcome of the management. Methods: A retrospective study of the patients treated at the M. S. Ramaiah Medical College and Teaching hospital, Bangalore from a total period of 5 years, from January 2009-January 2014. The epidemiological data and histopathological analysis of the ovarian cancer was done. Results: In the present study, a total of 106 ovarian cancer cases were included. Majority of the patients were in the age group 40-49 years (32%). Histopathological examination of the specimens revealed that serous adenocarcinoma was the commonest (42.4%) and the least common being yolk sac tumour (0.9%). Majority (n=49, 46.2%) of the patients presented in stage III. The chief complaint was abdominal pain (n=74,69.8%) followed by abdominal distension (n=55,51.8%). Conclusions: Majority of the patients who presented to us were in the perimenopausal age group at least 2 decades earlier to the western population and many of the patients presented with abdominal pain rather than abdominal distension. These observations warrant us to screen women at an earlier age and also think of this lethal malignancy in women who present with pain and other vague symptoms.
Ovarian cancer has progressively become leading cause of death in females of worldwide and has second position in the most common gynecological malignancy in India. This study was to evaluate the causative factors, clinical and histopathological detail of ovarian cancer cases registering in cancer hospital in Gwalior, and to increase awareness of gynecological malignancy among central region of India. Study was carried out in 56 cases of clinically proven ovarian cancer patients at cancer hospital and research institute, Gwalior, India. Different variables including age of patients at diagnosis, parity of patients, clinical profile includes levels of CA125, histological types and socio-demographic data were collected and analyzed. In this study, 87.5% of the cases were suffering from malignant while only 12.5 % had benign tumor. Most common symptom of complaints is abdominal distension (48.21%), abdominal pain (32.14%) and lower abdominal lump (26.78%). Multiparty was associated with the malignant ovarian cancer in 85.71% patients. This study found the epithelial ovarian cancer as the most common malignancy and both serous (25%) and mucinous cyst adenocarcinoma (21.42%) was the common variant of ovarian carcinoma found in our study.
Annals of Medical and Health Sciences Research, 2013
Background: The incidence of ovarian cancer is thought to be increasing in developing countries and little is known about the pattern and incidence of this disease in South-East Nigeria. Aims: The objectives of the study were to determine the incidence, describe the pattern and management of ovarian cancer at a tertiary medical center in Enugu South East Nigeria. Materials and Methods: This was a retrospective review of cases of histologically diagnosed primary ovarian cancer at the study center over 11 years.Cases of histologically diagnosed primary ovarian cancer were identified through the records of the study center cancer registry and confirmed from the records of the histopathology department. Case notes, admission and theatre records were used to obtain data relating to clinical management, mortality and incidence of primary ovarian cancer. Statistical analysis was dose using SPSS statistical software version 17.0 for windows. Descriptive and inferential statistics were applied to obtain rates, proportions and 95% confidence intervals for these estimates. Results: There were 20,227 gynecological admissions during the study period (from January 2000 to December 2010) and 206 gynecological cancers. There were 54 cases of primary ovarian cancer giving an incidence rate of 1/405 gynecological admissions per year or 0.3% (95% confidential interval [CI] 0.23%, 0.38%) or 2.4% (54/206) per gynecological cancer per year. Epithelial ovarian cancer constituted 68% of cases of ovarian cancer (95% CI 54%, 82%): Sex cord and germ cell tumors constituted 16% each (95% CI 6%, 26%). Approximately 60% of women who had epithelial ovarian cancer were aged 50 years or below (95% CI 47%, 74%) and 72% of epithelial ovarian cancer occurred in multiparous women (95% CI 72.1%, 91.9%). Over 84% of ovarian cancer presented in stages 3 and 4 of the disease (95% CI 94%, 72%). The mainstay of management was surgery: Compliance with cis-platinum based adjuvant chemotherapy was poor. Case-specific mortality rate within 1 year of diagnosis was, at least, 70% (95% CI 64%, 84%). Conclusions: Primary ovarian cancer was uncommon and consisted mainly of epithelial cancer. Epithelial ovarian cancer occurred more in multiparous women and in women under 50 years in our center contrary to the known pattern of the disease.