Hyperuricemia in Systemic Hypertension and its correlation with systolic and diastolic blood pressure (original) (raw)
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Association of serum uric acid with systemic blood pressure – A Cross Sectional study
The Professional Medical Journal, 2021
Objective: To determine association of Serum Uric Acid levels (SUA) in subjects suffering Systemic Blood Pressure and to determine its association with systolic and diastolic blood pressure. Study Design: Cross Sectional Study. Setting: Department of Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan. Period: January 2018 to September 2019. Material & Methods: 150 diagnosed cases of systemic hypertension and 150 controls were selected though non-probability purposive sampling according to inclusion and exclusion criteria. 2 ml venous blood was taken, centrifuged and sera were used for uric acid. Data was saved in a pre- structured Performa. Statistical software (SPSS v 21.0, IBM, Incorporation, USA) of data variables was analyzed at 95% CI (P ≤ 0.05). Results: Serum uric acid in controls was 2.93±0.72 compared to cases 4.25±1.44 mg/dl (P=0.0001). Hyperuricemia was observed in 58 (38.6%) cases compared to 23 (15.3%) controls. Uric acid shows ...
Indian Journal of Clinical Anatomy and Physiology, 2022
Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occ...
Background: uric acid, a final metabolic product of purine breakdown, appears as an etiology in gout. Higher levels have also been associated with hypertension, cardiovascular morbidity and mortality. Few studies have been conducted, especially in India, to elucidate the relationship between uric acid and prehypertension. Objective: In this study, the relationship between serum uric acid levels and blood pressure in the normotensive, prehypertensive and hypertensive population was evaluated. Also, it should be checked whether there is an incremental increase in serum uric acid with an increase in blood pressure. Place and Duration: In the Medicine department of Holy Family Hospital Rawalpindi for one year duration from March 2019 to February 2020. Material and methods: Two hundred OPD patients meeting the inclusion and exclusion criteria and were included in the study population. A venipuncture was measured to collect venous blood to measure the blood pressure of each participant and then serum uric acid. According to the classification of the National Joint Committee 7, the participants were divided into 4 groups such as Normal, Prehypertension, Hypertension -Stage 1, Hypertension Stage -2. The data were analyzed to determine and confirm serum uric acid levels from four categories. The relationship of uric acid with blood pressure. Results and conclusion: A gradual increase in serum uric acid levels was observed with an increase in blood pressure. A strong positive linear correlation was observed between serum uric acid levels and mean arterial pressure (Pearson correlation coefficient r = 0.74; p <0.0001). Uric acid was associated with blood pressure in the prehypertensive population (r = 0.442). Serum uric acid levels are associated with prehypertension and hypertension and are strong independent predictors of cardiovascular mortality.
Study of Association of Serum Uric Acid Level with Severity of Essential Hypertension
https://www.ijrrjournal.com/IJRR\_Vol.9\_Issue.2\_Feb2022/IJRR-Abstract060.html, 2022
Hypertension is one of the leading causes of the global burden of disease. Hyperuricemia is present in 25-50% of individuals with untreated primary hypertension, about 5 times the frequency found in normotensive persons. Raised serum uric acid concentrations in the blood are commonly encountered in essential hypertension. The hyperuricemia observed in untreated hypertension may reflect the decrease in renal blood flow and early hypertensive nephrosclerosis. Hence it is important to associate the serum uric acid level and the severity of hypertension and to find whether serum uric acid can be used as a useful tool to assess the severity of hypertension
International Journal of Advances in Medicine
Background: Serum uric acid has been closely linked and considered as an independent risk factor for development of hypertension. This study was carried out to assess the serum uric acid levels in essential hypertension and its correlation with the severity and known duration of hypertension.Methods: The present observational case control study was conducted between November 2019 to February 2020 on total 100 out patients (30-65 years) of which 50 known cases of essential hypertension irrespective of treatment status and were graded into different stages of hypertension as per Joint National Committee VII (JNC VII) guidelines. Rest 50 patients who were age- sex matched and without any co-morbidity were included as control. Relevant clinical and laboratory data were recorded using proforma. Statistical analysis was done using Statistical package for social software (SPSS) software.Results: Mean systolic/diastolic blood pressure (BP) was found significantly higher in cases 168/102 mmH...
Hypertension, 2000
The question of serum uric acid as an independent risk factor in subjects with essential hypertension remains controversial. For up to 12 years (mean, 4.0) we followed 1720 subjects with essential hypertension. At entry, all subjects were untreated and all were carefully screened for absence of cardiovascular disease, renal disease, cancer, and other important disease. Outcome measures included total cardiovascular events, fatal cardiovascular events, and all-cause mortality. During 6841 person-years of follow-up there were 184 cardiovascular events (42 fatal) and 80 deaths from all causes. In the 4 quartiles of serum uric acid (division points: 0.268, 0.309, and 0.369 mmol/L [4.5, 5.2, and 6.2 mg/dL] in men; 0.190, 0.232, and 0.274 mmol/L [3.2, 3.9, and 4.6 mg/dL] in women), the rate (per 100 person-years) of cardiovascular events was 2.51, 1.48, 2.66, and 4.27, that of fatal cardiovascular events was 0.41, 0.33, 0.38, and 1.23, and that of all-cause deaths was 1.01, 0.55, 0.93, and 2.01, respectively. The relation between uric acid and event rate was J-shaped in both genders. After adjustment for age, gender, diabetes, total cholesterol/HDL cholesterol ratio, serum creatinine, left ventricular hypertrophy, ambulatory blood pressure, and use of diuretics during follow-up, uric acid levels in the highest quartile were associated with increased risk for cardiovascular events (relative risk, 1.73; 95% CI, 1.01 to 3.00), fatal cardiovascular events (relative risk, 1.96; 95% CI, 1.02 to 3.79), and all-cause mortality (relative risk, 1.63; 95% CI, 1.02 to 2.57) in relation to the second quartile. In untreated subjects with essential hypertension, raised uric acid is a powerful risk marker for subsequent cardiovascular disease and all-cause mortality. (Hypertension.
Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults
Scientific Reports
experimental evidence suggests a causal role of serum uric acid (sUA) in hypertension development. Currently, there are few data available on the association between sUA and hypertension; data from Bangladeshi adults are not available yet. this study evaluated the association of sUA with hypertension among Bangladeshi adults. Blood samples were obtained from 140 males and 115 females and analyzed for SUA and lipid levels. Hypertension was defined as SBP ≥ 140 mmHg and/ or DBp ≥ 90 mmHg. All participants were divided into four quartiles based on SUA concentrations. Association of sUA with hypertension was evaluated by logistic regression models. the prevalence of hypertension and prehypertension was significantly higher in male (15.4 and 47.6%, respectively) than in the female (5.6 and 33.4%, respectively) subjects (p < 0.01). Males had a higher mean level of SUA (310.7 ± 67.9 µmol/L) than in the females (255.3 ± 69.3 µmol/L) (p < 0.001). Hyperuricemia was prevalent 9.1% in males and 10.3% in females. An increasing trend for hypertension and prehypertension was found in both genders with increasing sUA levels in the quartiles (p < 0.01). SUA levels in the quartiles were positively correlated with blood pressure (p < 0.01). After adjusting for baseline covariates, SUA levels were significantly associated with hypertension (p < 0.01). Findings of this study indicate the significance of maintaining normal SUA level to prevent hypertension.
Journal of Translational Medicine, 2016
Background: The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other known risk factors. We explored this relationship in a comprehensive Chinese senior dynamic cohort. Methods: To investigate the relationship between serum uric acid (SUA) levels and hypertension, we carried out a 6-year retrospective study (2006-2011) in a dynamic cohort with 3591 subjects free of hypertension. The first occasion of documented hypertension per subject was the index event. A Cox proportional hazards model assessed the relationship between SUA and hypertension. Kaplan-Meier survival analysis compared incidence of hypertension among individuals with each SUA quartile. Receiver operating characteristic curves were generated to obtain the area under the curve as a prediction of hypertension from SUA levels. Results: The cumulative prevalence of hypertension in our cohort was 20.7 %. The prevalence of hyperuricemia was 17.5 %. Cox regression analysis showed that, compared with the lowest SUA quartile (<4.69 mg/dl), the 4.69-5.58, 5.58-6.52, and ≥6.52 mg/dl quartiles yielded hazard ratios (95 % confidence intervals) for hypertension of 1.652 (1.265-2.156), 2.195 (1.705-2.825), and 3.058 (2.399-3.899), respectively. Cumulative incidence of hypertension was consistently higher among individuals with hyperuricemia than among those with normal SUA levels. A Kaplan-Meier survival analysis showed that hyperuricemia predicted higher incidences of hypertension in a dose-dependent manner: hypertension onset significantly differed across SUA quartiles. SUA levels were significantly and independently associated with incidence of hypertension in our cohort. Conclusions: Our results, controlling for known risk factors, suggest that SUA level is an independent risk factor for hypertension and could be a useful indicator of hypertension.
Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients
To determine whether pretreatment and/or in-treatment serum uric acid (SUA) is independently and specifically associated with cardiovascular events in hypertensive patients, we examined the 20-year experience of 7978 mild-to-moderate hypertensive participants in a systematic worksite treatment program. Clinical evaluation and treatment were protocol-directed. SUA was measured at entry and annually thereafter. Subjects were stratified according to gender-specific quartile of baseline SUA. Blood pressures at entry and in-treatment were, respectively, 152.5/95.6 and 138.9/85.4 mm Hg. SUA was normally distributed with a mean of 0.39960.0893 and 0.32160.0833 mmol/L for men and women, respectively. Subjects with highest SUA were heavier, had greater evidence of cardiovascular disease (CVD), higher systolic blood pressure, higher creatinine, more frequent diuretic use, and lower prevalence of diabetes. During an average follow-up of 6.6 years (52 751 patient-years), 548 CVD events (183 mor...