Effect of the Dexamethasone-Ondansetron Combination Versus Dexamethasone-Aprepitant Combination to Prevent Postoperative Nausea and Vomiting (original) (raw)
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Comparison of Dexamethasone with Ondansetron for Prevention of Post-Operative Nausea and Vomiting
Pakistan Journal of Medical and Health Sciences, 2021
Objective: To examine the effectiveness of dexamethasone and ondansetron in reducing the incidence of post-operative nausea and vomiting (PONV) in patients following laparoscopic surgery. Patients and Methods: A total number of 100 patients who were planned for laparoscopic surgery under general anesthesia having age 20-60 years were included in this study from a tertiary care hospital from Dec-2019 to June-2021. Patients were divided in to two group using Draw randomization technique. Group I; in these patients IV dexamethasone 8 mg was given at the time of induction of anesthesia. Group II; in these patients Ondansetron (4 mg IV) was given at induction of anesthesia. After completing the surgery and shifting the patient to the recovery room frequency of PONV within 6 hours after surgery was noted. Results: Mean age of the patients was 43.31±10.41 years. There were 54 (54.00%) male patients and 46 (46.00%) female patients. There were 75 (75.00%) patients with ASA I and 25 (25.00%) ...
Comparison of Dexamethasone and Ondansetrone Use in Prevention of Post-operative Nausea and Vomiting
Journal of Pharmaceutical Research International
Background: PONV remained the common cause of patient’s discomfort after anaesthesia 30% in all post-surgical patients and 80% in high-risk patients. With other common and serious complications of surgeries vomiting and nausea remained unpleasant trigger for patients who underwent the surgeries that prolongs the hospital stay and also leads to recurrent admissions. Therefore in this study we want to compare the effectiveness of pre-operative single-dose dexamethasone versus ondansetron in reducing post-operative nausea and vomiting after laparoscopic surgeries. Methods: Patients admitted for laparoscopic procedures at Ziauddin Hospital North site were recruited for this quasi-experimental study. All consecutive patients were assigned to one of the two groups (1 or 2) using computer generated simple randomised numbers and given either of the two treatments: single dose dexamethasone (5-8mg) or ondansetron (4mg). Researcher assessed post-operative nausea and vomiting at thirty minutes...
2021
Objective: To compare the efficacy of dexamethasone 8mg versus ondansetron 4mg in preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy Methodology: This quasi-experimental study was conducted at the Department of Anaesthesia and Intensive Care, Holy Family Hospital from 29th July 2018 to 28th January 2019. Anesthesia was induced with propofol (2mg/kg IV) and Atracurium (0.5 mg/kg IV) was given to facilitate tracheal intubation. Nalbuphine (0.2mg/kg) was used as analgesic.Patients were randomly divided into two groups. Patients in Group A received 4mg ondansetron at end of surgery and Group B received 8mg dexamethasone at induction. Results: A total of 90 patients were included according to the inclusion criteria of the study. The mean age (years) in the study was 37.11+10.60 years. Frequency and percentage of nausea (up to 24 hours) among both the groups was 28 (62.2) and 28 (62.2) respectively (p-value = 1.0) while the frequency and percentage of vomiting (within 24 hours after extubation) was 28 (62.2) and 27 (60.0) respectively (p-value = 0.829) Conclusion: The study concluded that there was no significant difference dexamethasone and ondansetron in preventing postoperative nausea and vomiting.
Middle East journal of anaesthesiology, 2010
In a prospective randomized double-blind study, we compared the effectiveness of dexamethasone 8 mg with either granisetron 1 mg or ondansetron 4 mg in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery. Hundred ASA I and II patients scheduled for laparoscopic surgery were enrolled in the study and 84 patients completed it. Following induction of anesthesia, group I (n=42) received granisetron 1 mg and dexamethasone 8 mg, group II (n=42) received ondansetron 4 mg and dexamethasone 8 mg. Nausea and vomiting episodes, pain scores as well as side effects were recorded during the first hour and subsequently during the first 6 and 24 hours postoperatively. Satisfaction scores were obtained at discharge. There was no statistically significant difference between the 2 groups during the 1st 24 hours following surgery in regards to pain scores, satisfaction and side effects manifestations. At 0-1 hour interval, 100% of patients in group I and 97.6...
The Egyptian Journal of Hospital Medicine
Background: postoperative nausea and vomiting (PONV) are a common distressing symptoms in patients undergoing laparoscopic surgery and can contribute to anxiety, dehydration, metabolic abnormality, wound disruption, delayed recovery and other issues. The incidence of PONV varies from 20 to 80 % of all surgeries, and it is an economic and social burden. Aim of the Work: was to assess whether dexamethasone is a costeffective alternative to ondansetron in the prevention of PONV in patients undergoing laparoscopic surgery.
Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting
British Journal of Anaesthesia, 1996
We studied 100 ASA I-II females undergoing general anaesthesia for major gynaecological surgery, in a prospective, double-blind, placebocontrolled, randomized study. Patients received one of four regimens for the prevention of postoperative nausea and vomiting (PONV): ondansetron 4 mg (n : 25), dexamethasone 8 mg (n : 25), ondansetron with dexamethasone (4 mg and 8 mg, respectively, n : 25) or placebo (saline, n : 25) There were no differences in background factors or factors related to operation and anaesthesia, morphine consumption, pain or side effects between groups. The incidence of nausea and emetic episodes in the ondansetron with dexamethasone group was lower than in the placebo (P : 0.01), ondansetron (P : 0.05) and dexamethasone (P : 0.057) groups. There were no differences between ondansetron and dexamethasone, and both were more effective than placebo (P : 0.05 and P : 0.01, respectively). Dexamethasone appeared to be preferable in preventing nausea than emetic episodes. Fewer patients in the ondansetron with dexamethasone group needed antimetic rescue (P : 0.01 vs placebo and P : 0.05 vs ondansetron). We conclude that prophylactic administration of combined ondansetron and dexamethasone is effective in preventing PONV. (Br.
2016
Recent studies have shown that aprepitant, a substance – P/ Nk 1 receptor antagonist is effective in postoperative vomiting. The present study was designed to find out whether addition of aprepitant to ondansetron would be more effective than ondansetron alone in prevention of post operative nausea and vomiting in patients undergoing laparoscopic surgeries. After obtaining informed consent, 50 patients with ASA grade I and II between 25 55 years of age undergoing laparoscopic surgery under general anaesthesia were randomly divided into two groups of 25 patients each. GroupI received 4 mg of ondansetron i.v and Group II received the 4mg of ondansetron i.v with 40mg oral of aprepitant before induction. Incidence and severity of nausea, vomiting was recorded at 2, 6, 24, 48 hours postoperatively by using a standard verbal response scale ranging from 0 to 3 (0 no nausea / vomiting; 1 mild nausea / vomiting; 2 moderate nausea / vomiting; 3 severe nausea / vomiting. The data was subjected...
Journal of the College of Physicians and Surgeons, 2008
To compare the efficacy of combination of dexamethasone plus ondansetron with dexamethasone alone for postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Double blinded randomized controlled clinical trial. Department of Anaesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from March 2007 to September 2007. One hundred patients, both male and female, age 20 to 50 years, ASA Physical status I and II, scheduled for elective laparoscopic cholecystectomy under general anaesthesia were randomly allocated to two groups. Group A received dexamethasone (2 ml) plus ondansetron 4 mg (2 ml) prepared in two different syringes, and group B received dexamethasone 8 mg (2 ml) and normal saline (2 ml), prepared in two separate syringes just before induction of anaesthesia. Anaesthesia was standardized. For the first 24 hours after anaesthesia, the presence or absence of nausea and vomitin...