Comparative In Vitro Activities of ABT-773 against 362 Clinical Isolates of Anaerobic Bacteria (original) (raw)

2001, Antimicrobial Agents and Chemotherapy

The activity of ABT-773, a novel ketolide antibiotic, against clinical isolates of anaerobic bacteria was determined and compared to the activities of other antimicrobial agents. MICs at which 90% of isolates were inhibited (MIC90s) were ≤0.06 μg/ml for Actinomyces spp., Clostridium perfringens, Peptostreptococcus spp.,Propionibacterium spp., and Porphyromonasspp. The MIC50s and MIC90s were ≤0.06 and >32 μg/ml, respectively, for Eubacterium spp.,Lactobacillus spp., Clostridium difficile, and Clostridium ramosum. The MIC90 for Bilophila wadsworthia,Bacteroides ureolyticus, and Campylobacter gracilis was 1 μg/ml, and that for Prevotella bivia and other Prevotella spp. was 0.5 μg/ml. The MIC90 for Fusobacterium nucleatum was 8 μg/ml, and that for Fusobacterium mortiferum and Fusobacterium varium was >32 μg/ml. The MIC90s for theBacteroides fragilis group were as follows: forB. fragilis, 8 μg/ml; for Bacteroides thetaiotaomicron, Bacteroides ovatus,Bacteroides distasonis, and Bact...